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Formulated Chinese Medicine Shaoyao Gancao Tang Reduces Tau Aggregation and Exerts Neuroprotection through Anti-Oxidation and Anti-Inflammation

to Guey-Jen Lee-Chen; wt.ude.untn@91034t and Chiung-Mei Chen; wt.gro.hmgc.mda@nehcmc Received 11 May 2018; Accepted 29 July 2018; Published 28 October 2018 Academic Editor: Francisco Jaime Bezerra ... Interest The authors declare no conflicts of interest. Authors’ Contributions Guey-Jen Lee-Chen and Chiung-Mei Chen designed the research and revised the paper. I-Cheng Chen performed the experiments

Formulated Chinese Medicine Shaoyao Gancao Tang Reduces Tau Aggregation and Exerts Neuroprotection through Anti-Oxidation and Anti-Inflammation

to Guey-Jen Lee-Chen; wt.ude.untn@91034t and Chiung-Mei Chen; wt.gro.hmgc.mda@nehcmc Received 11 May 2018; Accepted 29 July 2018; Published 28 October 2018 Academic Editor: Francisco Jaime Bezerra ... Interest The authors declare no conflicts of interest. Authors’ Contributions Guey-Jen Lee-Chen and Chiung-Mei Chen designed the research and revised the paper. I-Cheng Chen performed the experiments

Modeling Alzheimer’s Disease by Induced Pluripotent Stem Cells Carrying APP D678H Mutation

Alzheimer’s disease (AD), probably caused by abnormal accumulation of β-amyloid (Aβ) and aberrant phosphorylation of tau, is the most common cause of dementia among older people. Generation of patient-specific neurons by induced pluripotent stem cell (iPSC) technology facilitates exploration of the disease features in live human neurons from AD patients. In this study, we...

Detection of mitochondrial DNA with 4977 bp deletion in leukocytes of patients with ischemic stroke

/ 11 Author Contributions Conceptualization: Yu-hua Huang, Yi-Chun Chen. Data curation: Chiung-Mei Chen, Kuo-Hsuan Chang, Huei-Wen Chen. Formal analysis: Yu-hua Huang, Huei-Wen Chen. Methodology ... : Chiung-Mei Chen, Yun-Shien Lee, Kuo-Hsuan Chang. Project administration: Yi-Chun Chen. Supervision: Yi-Chun Chen. Writing ± original draft: Yu-hua Huang. Writing ± review & editing: Yi-Chun Chen. 9

Correction to: Non-alcoholic Wernicke’s encephalopathy with cortical involvement and polyneuropathy following gastrectomy

In the original publication of the article, author name Hong-Shiu Chang was incorrectly written as Hong-Chiu Chang.

Disturbance of Plasma Lipid Metabolic Profile in Guillain-Barre Syndrome

• PubMed • Google Scholar Search for Chiung-Mei Chen in:Nature Research journals • PubMed • Google Scholar Contributions C.-M.C., M.-L.C., and D.T.-Y.C. designed and supervised the study. H.-Y.T., J.-F.L ... and controls. Competing Interests The authors declare that they have no competing interests. Corresponding authors Correspondence to Mei-Ling Cheng or Chiung-Mei Chen. Electronic supplementary

Polymorphisms in the Promoters of the MMP-2 and TIMP-2 Genes Are Associated with Spontaneous Deep Intracerebral Hemorrhage in the Taiwan Population

Background Spontaneous intracerebral hemorrhage (ICH) is a devastating stroke subtype. Matrix metalloproteinases (MMPs) function in the degradation of extracellular matrix and the activities of MMPs are modulated by their endogenous inhibitors, tissue inhibitors of metalloproteinases (TIMPs). This study aimed to discuss relationship of MMP-2 and TIMP-2 to spontaneous deep ICH...

Association of MMP-9 Haplotypes and TIMP-1 Polymorphism with Spontaneous Deep Intracerebral Hemorrhage in the Taiwan Population

Background Spontaneous deep intracerebral hemorrhage (SDICH) is a devastating stroke subtype. The causes of SDICH are heterogeneous. Matrix metalloproteinase-9 (MMP-9, Gelantinase B) has been shown to relate to stroke and the development of aneurysm and may increase risks of intracerebral hemorrhage. MMP activities are modulated by their endogenous inhibitors, tissue inhibitors...

Role of High Mobility Group Box 1 (HMGB1) in SCA17 Pathogenesis

Spinocerebellar ataxia type 17 (SCA17) involves the expression of a polyglutamine (polyQ) expanded TATA-binding protein (TBP), a general transcription initiation factor. TBP interacts with other protein factors, including high mobility group box 1 (HMGB1), to regulate gene expression. Previously, our proteomic analysis of soluble proteins prepared from mutant TBP (TBP/Q61...

Inhibition of soluble tumor necrosis factor is therapeutic in Huntington's disease

Neuroinflammation is a common feature of many neurodegenerative diseases, including Huntington's disease (HD). HD is an autosomal dominant genetic disease caused by an expanded CAG repeat in exon 1 of the huntingtin (HTT) gene. Previous studies demonstrated that levels of several proinflammatory cytokines, including tumor necrosis factor (TNF)-α, were higher in the plasma and...

High Protein Diet and Huntington's Disease

Huntington’s disease (HD) is a neurodegenerative disorder caused by the huntingtin (HTT) gene with expanded CAG repeats. In addition to the apparent brain abnormalities, impairments also occur in peripheral tissues. We previously reported that mutant Huntingtin (mHTT) exists in the liver and causes urea cycle deficiency. A low protein diet (17%) restores urea cycle activity and...

Genetic Variations of GAK in Two Chinese Parkinson’s Disease Populations: A Case-Control Study

Cyclin G-associated kinase (GAK) modifies α–synuclein expression levels and affects the susceptibility of Parkinson’s disease (PD). The single-nucleotide polymorphism (SNP) rs1564282 of GAK gene has a significant association to the risk of PD among Caucasian populations. To date there is only one data with regards to ethnic Chinese from Mainland China. Here, we conducted a case...

Downregulation of Genes Involved in Metabolism and Oxidative Stress in the Peripheral Leukocytes of Huntington's Disease Patients

-Mei Chen 0 David R. Borchelt, University of Florida, United States of America 0 Department of Neurology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine , Taipei , Taiwan

Deactivation of TBP contributes to SCA17 pathogenesis

Spinocerebellar ataxia type 17 (SCA17) is an autosomal dominant cerebellar ataxia caused by the expansion of polyglutamine (polyQ) within the TATA box-binding protein (TBP). Previous studies have shown that polyQ-expanded TBP forms neurotoxic aggregates and alters downstream genes. However, how expanded polyQ tracts affect the function of TBP and the link between dysfunctional...

Comparison between the cranial magnetic resonance imaging features of neuromyelitis optica spectrum disorder versus multiple sclerosis in Taiwanese patients

Background Neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS) are inflammatory diseases of the central nervous system with different pathogenesis, brain lesion patterns, and treatment strategies. However, it is still difficult to distinguish these two disease entities by neuroimaging studies. Herein, we attempt to differentiate NMOSD from MS by comparing...

Comparison between the cranial magnetic resonance imaging features of neuromyelitis optica spectrum disorder versus multiple sclerosis in Taiwanese patients

Neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS) are inflammatory diseases of the central nervous system with different pathogenesis, brain lesion patterns, and treatment strategies. However, it is still difficult to distinguish these two disease entities by neuroimaging studies. Herein, we attempt to differentiate NMOSD from MS by comparing brain lesion...

Clinical Correlations of Motor and Somatosensory Evoked Potentials in Neuromyelitis Optica

Background Motor and somatosensory evoked potentials (MEPs and SSEPs) are sensitive tools for detecting subclinical lesions, assessing disease severity, and determining the prognosis for outcomes of patients with inflammatory neurological diseases such as multiple sclerosis. However, their roles in neuromyelitis optica (NMO), a severe inflammatory neurological disease that...

SLC1A2 Variant Is Associated with Essential Tremor in Taiwanese Population

Essential tremor (ET), which is one of the most common movement disorders, may lead to severe interference in quality of life. The first genome-wide association study (GWAS) has identified an association of the LINGO1 variant (rs9652490) with ET in Americans and Europeans. Recently, a second GWAS that was performed in a European population has discovered a new variant (rs3794087...

FBXO7 Y52C Polymorphism as a Potential Protective Factor in Parkinson's Disease

Mutations in the F-box only protein 7 gene (FBXO7), the substrate-specifying subunit of SCF E3 ubiquitin ligase complex, cause Parkinson's disease (PD)-15 (PARK15). To identify new variants, we sequenced FBXO7 cDNA in 80 Taiwanese early onset PD patients (age at onset ≤50) and only two known variants, Y52C (c.155A>G) and M115I (c.345G>A), were found. To assess the association of...

Increased Prothrombin, Apolipoprotein A-IV, and Haptoglobin in the Cerebrospinal Fluid of Patients with Huntington's Disease

each patient was assessed by clinicians (Yih-Ru Wu and Chiung-Mei Chen) in outpatient clinics before the CSF and serum were collected and investigated for proteomic profile. Therefore, the clinicians