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In vivo continuous evolution of metabolic pathways for chemical production

Microorganisms have long been used as chemical plant to convert simple substrates into complex molecules. Various metabolic pathways have been optimised over the past few decades, but the progresses were limited due to our finite knowledge on metabolism. Evolution is a knowledge-free genetic randomisation approach, employed to improve the chemical production in microbial cell...

Physical Simulation and Monitoring the Deformation and Fracture of Roadway in Coal Mining

Aiming at the large deformation and the dynamic fracture of roadway during the underground excavation or mining, a physical simulation and strain testing system was established, and the deformation process of surrounding body and its inner strain characteristics of the simulated roadway under loading was carried out. Results showed that the inner strain change of the measurement...

Mechanical Properties of Steel Fiber-Reinforced Magnesium Phosphate Cement Mortar

A new cement-based mortar with high early strength and toughness was developed by adding micro steel fibers (MSF) in magnesium phosphate cement (MPC) mortar. The compressive and flexural tests were carried out to investigate the effect of curing time, MSF volume fraction, sand-cement mass ratio, and water-cement mass ratio on the strength and flexural toughness of MSF-reinforced...

Mechanical Properties of Steel Fiber-Reinforced Magnesium Phosphate Cement Mortar

A new cement-based mortar with high early strength and toughness was developed by adding micro steel fibers (MSF) in magnesium phosphate cement (MPC) mortar. The compressive and flexural tests were carried out to investigate the effect of curing time, MSF volume fraction, sand-cement mass ratio, and water-cement mass ratio on the strength and flexural toughness of MSF-reinforced...

Generating porosity spectrum of carbonate reservoirs using ultrasonic imaging log

Imaging logging tools can provide us the borehole wall image. The micro-resistivity imaging logging has been used to obtain borehole porosity spectrum. However, the resistivity imaging logging cannot cover the whole borehole wall. In this paper, we propose a method to calculate the porosity spectrum using ultrasonic imaging logging data. Based on the amplitude attenuation...

Pooled CRISPR interference screening enables genome-scale functional genomics study in bacteria with superior performance

To fully exploit the microbial genome resources, a high-throughput experimental platform is needed to associate genes with phenotypes at the genome level. We present here a novel method that enables investigation of the cellular consequences of repressing individual transcripts based on the CRISPR interference (CRISPRi) pooled screening in bacteria. We identify rules for guide...

Programming for increased expression of hippocampal GAD67 mediated the hypersensitivity of the hypothalamic–pituitary–adrenal axis in male offspring rats with prenatal ethanol exposure

An imbalance of excitatory and inhibitory signals in the brain has been proposed to be one of the main pathological features of various diseases related to hypothalamic–pituitary–adrenal axis (HPAA) dysfunction. Excessive glutamate release induces neuronal excitotoxicity, while glutamic acid decarboxylase (GAD) 67 promotes the transformation of excessive glutamate to...

The Time-Space Joint Response Characteristics of AE-UT under Step Loading and Its Application

The acoustic emission (AE) and ultrasonic (UT) simultaneous monitoring program is designed using concrete samples under step loading. The time-varying response characteristics of AE-UT are studied and the cross-correlation analysis between AE-UT parameters is obtained. Moreover, the joint response of UT-AE spatial distribution field is analyzed, and an AE-UT joint monitoring...

Memory enhancing effects of BPN14770, an allosteric inhibitor of phosphodiesterase-4D, in wild-type and humanized mice

contributed equally: Chong Zhang, Ying Xu AffiliationsDepartment of Pharmacology and Toxicology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo ... ZhangCenter for Hearing & Deafness, University at Buffalo, State University of New York, Buffalo, NY, 14214, USABenjamin D. Auerbach & Richard J. Salvi AuthorsSearch for Chong Zhang in:Nature Research journals

Long-term groundwater storage changes and land subsidence development in the North China Plain (1971–2015)

The North China Plain (NCP) has been suffering from groundwater storage (GWS) depletion and land subsidence for a long period. This paper collects data on GWS changes and land subsidence from in situ groundwater-level measurements, literature, and satellite observations to provide an overview of the evolution of the aquifer system during 1971–2015 with a focus on the sub-regional...

The novel 19q13 KRAB zinc-finger tumour suppressor ZNF382 is frequently methylated in oesophageal squamous cell carcinoma and antagonises Wnt/β-catenin signalling

Zinc finger proteins (ZFPs) are the largest transcription factor family in mammals. About one-third of ZFPs are Krüppel-associated box domain (KRAB)-ZFPs and involved in the regulation of cell differentiation/proliferation/apoptosis and neoplastic transformation. We recently identified ZNF382 as a novel KRAB-ZFP epigenetically inactivated in multiple cancers due to frequent...

microRNA-874 suppresses tumor proliferation and metastasis in hepatocellular carcinoma by targeting the DOR/EGFR/ERK pathway

AffiliationsDepartment of General Surgery, Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221000, ChinaYi Zhang, Yangchao Wei, Xuan Li, Jun Song, Xiuzhong Zhang, Chong Zhang, Jian Niu, Pengbo Zhang, Zeqiang Ren ... • PubMed • Google Scholar Search for Chong Zhang in:Nature Research journals • PubMed • Google Scholar Search for Jian Niu in:Nature Research journals • PubMed • Google Scholar Search for Pengbo Zhang

Multiple pulmonary metastases in recurrent intracranial meningioma: Case report and literature review

Multiple pulmonary metastases from meningioma are rare. We report here a 59-year-old man with multiple pulmonary metastases from a recurrent intracranial meningioma. The primary intracranial tumour in the left occiput was totally excised in 2009. Pathological examination confirmed the diagnosis of atypical meningioma and adjuvant radiotherapy was given to help prevent recurrence...

Comparison of the Pharmacological Profiles of Selective PDE4B and PDE4D Inhibitors in the Central Nervous System

Inhibition of cyclic AMP (cAMP)-specific phosphodiesterase 4 (PDE4) has been proposed as a potential treatment for a series of neuropsychological conditions such as depression, anxiety and memory loss. However, the specific involvement of each of the PDE4 subtypes (PDE4A, 4B and 4C) in different categories of behavior has yet to be elucidated. In the present study, we compared...

3D membrane segmentation and quantification of intact thick cells using cryo soft X-ray transmission microscopy: A pilot study

Structural analysis of biological membranes is important for understanding cell and sub-cellular organelle function as well as their interaction with the surrounding environment. Imaging of whole cells in three dimension at high spatial resolution remains a significant challenge, particularly for thick cells. Cryo-transmission soft X-ray microscopy (cryo-TXM) has recently gained...

Clinicopathological and prognostic significance of GPX2 protein expression in esophageal squamous cell carcinoma

Background Chaoshan region, a littoral area of Guangdong province in southern China, has a high incidence of esophageal squamous cell carcinoma (ESCC). At present, the prognosis of ESCC is still very poor, therefore, there is urgent need to seek valuable molecular biomarker for prognostic evaluation to guide clinical treatment. GPX2, a selenoprotein, was exclusively expressed in...

Deformation and Failure Characteristics of the Rock Masses around Deep Underground Caverns

250061, China Received 4 May 2015; Accepted 9 July 2015 Academic Editor: Paolo Lonetti Copyright © 2015 Chong Zhang et al. This is an open access article distributed under the Creative Commons ... , the failure of a cavern with a relatively small cavern-excavation load is relatively less severe. Conflict of Interests The authors declare no conflict of interests. Authors’ Contribution Chong Zhang

Deformation and Failure Characteristics of the Rock Masses around Deep Underground Caverns

250061, China Received 4 May 2015; Accepted 9 July 2015 Academic Editor: Paolo Lonetti Copyright © 2015 Chong Zhang et al. This is an open access article distributed under the Creative Commons ... , the failure of a cavern with a relatively small cavern-excavation load is relatively less severe. Conflict of Interests The authors declare no conflict of interests. Authors’ Contribution Chong Zhang