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30 papers found.
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Differential modulation of pulmonary caspases: Is this the key to Ureaplasma-driven chronic inflammation?

Silwedel, Markus Fehrholz, Christian P. Speer, Kirsten Glaser. Data curation: Christine Silwedel, Markus Fehrholz, Kirsten Glaser. Formal analysis: Christine Silwedel, Markus Fehrholz, Christian P. Speer ... , Steffi Manig, Kirsten Glaser. Investigation: Christine Silwedel. Methodology: Christine Silwedel, Kirsten Glaser. 13 / 18 Project administration: Christine Silwedel, Christian P. Speer. Software

Effect of progesterone on Smad signaling and TGF-β/Smad-regulated genes in lung epithelial cells

. Supervision: Steffen Kunzmann, Christian P. Speer, Markus Fehrholz. Validation: Steffen Kunzmann, Markus Fehrholz. Writing ? original draft: Steffen Kunzmann, Markus Fehrholz. Writing ? review & editing ... : Steffen Kunzmann, Barbara Ottensmeier, Christian P. Speer, Markus Fehrholz. 11 / 13 12 / 13 1. Romero R , Dey SK , Fisher SJ . Preterm labor: one syndrome, many causes . Science . 2014 ; 345 ( 6198 ): 760

Ureaplasma isolates stimulate pro-inflammatory CC chemokines and matrix metalloproteinase-9 in neonatal and adult monocytes

Henrich, Christian P. Speer. Data curation: Kirsten Glaser. Formal analysis: Kirsten Glaser, Christine Silwedel, Markus Fehrholz, Birgit Henrich, Heike Claus, Christian P. Speer. 12 / 17 Funding ... acquisition: Christian P. Speer. Investigation: Kirsten Glaser, Christine Silwedel, Markus Fehrholz, Ana Maria Waaga-Gasser. Methodology: Kirsten Glaser, Christine Silwedel, Birgit Henrich, Ana Maria Waaga

Effects of the New Generation Synthetic Reconstituted Surfactant CHF5633 on Pro- and Anti-Inflammatory Cytokine Expression in Native and LPS-Stimulated Adult CD14+ Monocytes

Background Surfactant replacement therapy is the standard of care for the prevention and treatment of neonatal respiratory distress syndrome. New generation synthetic surfactants represent a promising alternative to animal-derived surfactants. CHF5633, a new generation reconstituted synthetic surfactant containing SP-B and SP-C analogs and two synthetic phospholipids has...

Impact of the New Generation Reconstituted Surfactant CHF5633 on Human CD4+ Lymphocytes

Background Natural surfactant preparations, commonly isolated from porcine or bovine lungs, are used to treat respiratory distress syndrome in preterm infants. Besides biophysical effectiveness, several studies have documented additional immunomodulatory properties. Within the near future, synthetic surfactant preparations may be a promising alternative. CHF5633 is a new...

Caffeine and Rolipram Affect Smad Signalling and TGF-β1 Stimulated CTGF and Transgelin Expression in Lung Epithelial Cells

Caffeine administration is an important part of the therapeutic treatment of bronchopulmonary dysplasia (BPD) in preterm infants. However, caffeine mediated effects on airway remodelling are still undefined. The TGF-β/Smad signalling pathway is one of the key pathways involved in airway remodelling. Connective tissue growth factor (CTGF), a downstream mediator of TGF-β, and...

Multiple Antenatal Dexamethasone Treatment Alters Brain Vessel Differentiation in Newborn Mouse Pups

Antenatal steroid treatment decreases morbidity and mortality in premature infants through the maturation of lung tissue, which enables sufficient breathing performance. However, clinical and animal studies have shown that repeated doses of glucocorticoids such as dexamethasone and betamethasone lead to long-term adverse effects on brain development. Therefore, we established a...

Synergistic Effect of Caffeine and Glucocorticoids on Expression of Surfactant Protein B (SP-B) mRNA

Administration of glucocorticoids and caffeine is a common therapeutic intervention in the neonatal period, but possible interactions between these substances are still unclear. The present study investigated the effect of caffeine and different glucocorticoids on expression of surfactant protein (SP)-B, crucial for the physiological function of pulmonary surfactant. We measured...

Familial Pulmonary Capillary Hemangiomatosis Early in Life

Background. Pulmonary capillary hemangiomatosis (PCH) is a rare disease, especially in infancy. Four infants have been reported up to the age of 12 months. So far, no familial patients are observed at this age. Patients. We report three siblings, two female newborns and a foetus of 15-week gestation of unrelated, healthy parents suffering from histologically proven PCH. The first...

IFN-γ and TNF-α Synergize to Inhibit CTGF Expression in Human Lung Endothelial Cells

Connective tissue growth factor (CTGF/CCN2) is an angiogenetic and profibrotic factor, acting downstream of TGF-β, involved in both airway- and vascular remodeling. While the T-helper 1 (Th1) cytokine interferon-gamma (IFN-γ) is well characterized as immune-modulatory and anti-fibrotic cytokine, the role of IFN-γ in lung endothelial cells (LEC) is less defined. Tumour necrosis...

Poractant alfa (Curosurf®) increases phagocytosis of apoptotic neutrophils by alveolar macrophages in vivo

Background Clearance of apoptotic neutrophils in the lung is an essential process to limit inflammation, since they could become a pro-inflammatory stimulus themselves. The clearance is partially mediated by alveolar macrophages, which phagocytose these apoptotic cells. The phagocytosis of apoptotic immune cells by monocytes in vitro has been shown to be augmented by several...

Infection of Human Coronary Artery Endothelial Cells by Group B Streptococcus Contributes to Dysregulation of Apoptosis, Hemostasis, and Innate Immune Responses

 Anna Kobsar,1 Christian P. Speer,3 Susanne Kneitz,4 and Martin Eigenthaler1 1Institute of Clinical Biochemistry and Pathobiochemistry, University of Wuerzburg, D-97080 Wuerzburg, Germany 2Medical

Myocardial Response in Preterm Fetal Sheep Exposed to Systemic Endotoxinaemia

Wirbelauer, Christian P Speer & Boris W KramerDepartment of Obstetrics and Gynaecology, Hospital Osnabrück, Osnabrück D-49076, GermanyMarkus Gantert & Yves GarnierDepartment of Neonatology, University ... Children's Hospital, Würzburg D-97080, GermanyMatthias Seehase, Andreas Ladenburger, Steffen Kunzmann, Wolfgang Thomas, Johannes Wirbelauer & Christian P Speer AuthorsSearch for Matthias Seehase in:Nature

Bilateral Thalamic Lesions in a Newborn with Intrauterine Asphyxia After Maternal Cardiac Arrest — a Case Report with Literature Review

Journal of Perinatology 2001 Case Presentation Maya Caroline Banerjea Christian P. Speer 0 1 0 Childrens' Hospital, Department of Neonatology, University of Wuerzburg , Wuerzburg , Germany 1

Airway Concentrations of Angiopoietin-1 and Endostatin in Ventilated Extremely Premature Infants Are Decreased After Funisitis and Unbalanced With Bronchopulmonary Dysplasia/Death

A systemic inflammatory response of the fetus, reflected by histologic funisitis, is a risk factor for bronchopulmonary dysplasia (BPD). Impaired pulmonary angiogenesis accompanied by simplification and rarification of alveoli is a histologic hallmark of BPD. Angiopoietin-1 mediates vascular development, maturation, and stabilization. Endostatin mainly acts as an angiostatic...

Activation of Umbilical Cord Endothelial Cells and Fetal Inflammatory Response in Preterm Infants with Chorioamnionitis and Funisitis

Chorioamnionitis and funisitis are associated with preterm labor and postnatal morbidity. Activation of endothelium resulting in up-regulation of adhesion molecules seems to be a key mechanism in development of organ damage. We investigated whether chorioamnionitis with or without funisitis in preterm infants induced expression and shedding of adhesion molecules in the umbilical...

Decreased Expression of Angiogenic Factors in Placentas with Chorioamnionitis after Preterm Birth

Chorioamnionitis and funisitis are associated with neonatal morbidity and mortality. We hypothesized that chorioamnionitis may stress fetal endothelium, activate proinflammatory gene transcription. and affect angiogenic homeostasis in fetal capillaries. Placentas from preterm infants were stained for heat-shock protein 70, nuclear factor-κB, hypoxia-inducible factor-1α, and...

Plasma Concentrations of the Carboxyterminal Propeptide of Type I Procollagen (PICP) in Preterm Neonates from Birth to Term

Carboxyterminal propeptide of type I procollagen (PICP), a marker of bone formation, has not yet been studied in preterm infants. In this study, PICP concentrations were measured longitudinally for 12 wk after birth using the ELISA technique in 43 preterm infants with a gestational age (GA) ranging from 24–29 wk and in 35 preterm infants with a GA ranging from 30–34 wk. PICP...

Levels of Complement Anaphylatoxin C5a in Pulmonary Effluent Fluid of Infants at Risk for Chronic Lung Disease and Effects of Dexamethasone Treatment

ABSTRACT: A number of studies have shown that increased numbers of neutrophils and macrophages are recruited into the airways during the development of chronic lung disease (CLD) in preterm infants. The objective of this study was to determine whether the anaphylatoxin C5a is detectable in tracheobronchial aspirate fluid of infants at risk for CLD and to evaluate the possible...

Natural Porcine Surfactant (Curosurf®) Down-Regulates mRNA of Tumor Necrosis Factor-α (TNF-α) and TNF-α Type II Receptor in Lipopolysaccharide-Stimulated Monocytes

We have previously shown that Curosurf®, a natural porcine surfactant, and its phospholipids effectively suppressed secretion of tumor necrosis factor (TNF-α) by resting and through lipopolysaccharide(LPS)-stimulated human monocytes. In this study the effect of Curosurf® on monocyte mRNA for TNF-α and TNF-α type II-receptor(TNF-α-RII) were analyzed to evaluate the cellular...