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Exercise Dose Effects on Body Fat 12 Months after an Exercise Intervention: Follow-up from a Randomized Controlled Trial

, University of Alberta, Edmonton, Alberta, Canada Correspondence should be addressed to Christine M. Friedenreich; ac.secivreshtlaehatrebla@hciernedeirf.enitsirhc Received 10 September 2018; Revised 9 ... December 2018; Accepted 30 December 2018; Published 20 January 2019 Academic Editor: Aron Weller Copyright © 2019 Christine M. Friedenreich et al. This is an open access article distributed under the

Aerobic exercise and DNA methylation in postmenopausal women: An ancillary analysis of the Alberta Physical Activity and Breast Cancer Prevention (ALPHA) Trial

Canadian Breast Cancer Research Alliance (No. 13576 and No. 017468) and the Alberta Cancer Foundation (No. 22170) to Christine M Friedenreich. The ALPHA ancillary study was funded by grants from Canadian ... Institutes for Health Research and the Canadian Cancer Society (No. MOP-130238) to Christine M Friedenreich. Funding for the DNA extraction was provided by an Alberta Cancer Foundation grant for the

Effects of prescribed aerobic exercise volume on physical activity and sedentary time in postmenopausal women: a randomized controlled trial

Physical activity has emerged as an important lifestyle factor for primary prevention of numerous diseases, including postmenopausal breast cancer. No study to date has assessed the acute and long-term effects of year-long aerobic exercise programs differing in prescribed exercise volume on physical activity and sedentary time in postmenopausal women. Therefore, we aimed to...

Epidemiology and biology of physical activity and cancer recurrence

Christine M. Friedenreich 3 Department of Community Health Sciences, Cumming School of Medicine, University of Calgary , Calgary, AB , Canada Physical activity is emerging from epidemiologic research as a

Physical activity does not alter prolactin levels in post-menopausal women: results from a dose-response randomized controlled trial

Background Increased circulating levels of prolactin have been associated with increased risk of both in situ and invasive breast cancer. We investigated whether or not physical activity had a dose–response effect in lowering plasma levels of prolactin in postmenopausal women. Methods Four hundred previously inactive but healthy postmenopausal women aged 50–74 years of age were...

Predictors of physical activity at 12 month follow-up after a supervised exercise intervention in postmenopausal women

Background Few studies have examined recreational physical activity (RPA) after participating in a structured exercise intervention. More specifically, little is known about the long-term effects of exercise interventions in post-menopausal women. This study had two objectives: 1) To compare RPA in postmenopausal women in the exercise group and the control group 12 months after...

The Influence of Energetic Factors on Biomarkers of Postmenopausal Breast Cancer Risk

from the Canadian Institutes for Health Research and AI-HS. Compliance with Ethics Guidelines Conflict of Interest Heather K. Neilson, Shannon M. Conroy, and Christine M. Friedenreich declare that they

Development and testing of a past year measure of sedentary behavior: the SIT-Q

Council # 586727 and the Victorian Government’s Operational Infrastructure Support Program. Christine M. Friedenreich is funded by an Alberta Innovates-Health Solutions Health Senior Scholar Award, and is

Breast cancer survival among young women: a review of the role of modifiable lifestyle factors

Almost 7 % of breast cancers are diagnosed among women age 40 years and younger in Western populations. Clinical outcomes among young women are worse. Early age-of-onset increases the risk of contralateral breast cancer, local and distant recurrence, and subsequent mortality. Breast cancers in young women (BCYW) are more likely to present with triple-negative (TNBC), TP53...

Study design and methods for the Breast Cancer and Exercise Trial in Alberta (BETA)

Background Exercise has favorable effects on biomarkers associated with a lower risk of breast cancer, however it is unclear if higher doses of exercise provide additional effects. No clinical trial has systematically examined how different exercise volumes influence the mechanisms underlying breast cancer etiology. The Breast Cancer and Exercise Trial in Alberta (BETA) - a...

Cerebrovascular Responsiveness to Hypercapnia Is Stable over Six Months in Older Adults

The primary purpose of this Brain in Motion (BIM) sub-study was to determine the 6-month stability of resting blood flow velocity and cerebrovascular responsiveness to a euoxic hypercapnic challenge in a group of physically inactive community dwelling men and men aged ≥55 yrs (range 55–92 yrs). At baseline and 6 months later 88 women (65±6 yr) and 78 men (67±7 yr) completed a...

Case–control study of lifetime alcohol consumption and endometrial cancer risk

Purpose Alcohol consumption is hypothesized to increase the risk of endometrial cancer by increasing circulating estrogen levels. This study sought to investigate the association between lifetime alcohol consumption and endometrial cancer risk. Methods We recruited 514 incident endometrial cancer cases and 962 frequency age-matched controls in this population-based case–control...

Hours spent and energy expended in physical activity domains: Results from The Tomorrow Project cohort in Alberta, Canada

Background Knowledge of adult activity patterns across domains of physical activity is essential for the planning of population-based strategies that will increase overall energy expenditure and reduce the risk of obesity and related chronic diseases. We describe domain-specific hours of activity and energy expended among participants in a prospective cohort in Alberta, Canada...

The Sedentary Time and Activity Reporting Questionnaire (STAR-Q): Reliability and Validity Against Doubly Labeled Water and 7-Day Activity Diaries

Prevention Research, CancerControl Alberta, Alberta Health Services, Calgary, Alberta, Canada (Ilona Csizmadi, Heather K. Neilson, Karen A. Kopciuk, Farah Khandwala, Andrew Liu, Christine M. Friedenreich ... ); Department of Oncology, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada (Ilona Csizmadi, Karen A. Kopciuk, Christine M. Friedenreich); Department of Community Health Sciences, Faculty of

Physical Activity, Biomarkers, and Disease Outcomes in Cancer Survivors: A Systematic Review

Background Cancer survivors often seek information about how lifestyle factors, such as physical activity, may influence their prognosis. We systematically reviewed studies that examined relationships between physical activity and mortality (cancer-specific and all-cause) and/or cancer biomarkers.

Anthropometric Measures and the Risk of Endometrial Cancer, Overall and by Tumor Microsatellite Status and Histological Subtype

Research Institute, Tampa, Florida (Ernest K. Amankwah); Population Health ResearchCancer Care, Alberta Health Services, Calgary, Alberta, Canada (Christine M. Friedenreich, Thomas Speidel, Annie R. Langley ... , Linda S. Cook); Department of Oncology, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada (Christine M. Friedenreich, Linda S. Cook); Department of Community Health Sciences, Faculty of

Predictors of adherence to different types and doses of supervised exercise during breast cancer chemotherapy

Background Exercise is beneficial for breast cancer patients during chemotherapy but adherence to different types and doses of exercise is a challenge. The purpose of this study was to examine predictors of adherence to different types and doses of exercise during breast cancer chemotherapy in a multicenter randomized controlled trial. Methods Breast cancer patients in Edmonton...

Case–control study of lifetime total physical activity and endometrial cancer risk

A population-based case–control study of physical activity and endometrial cancer risk was conducted in Alberta between 2002 and 2006. Incident, histologically confirmed cases of endometrial cancer (n = 542) were frequency age-matched to controls (n = 1,032). The Lifetime Total Physical Activity Questionnaire was used to measure occupational, household, and recreational activity...

Effects of Exercise Dose and Type During Breast Cancer Chemotherapy: Multicenter Randomized Trial

Background Exercise improves physical functioning and symptom management during breast cancer chemotherapy, but the effects of different doses and types of exercise are unknown.

Mediators and moderators of the effects of a year-long exercise intervention on endogenous sex hormones in postmenopausal women

Objective To identify factors that mediate or moderate the effects of exercise on postmenopausal sex hormone concentrations. Methods Postmenopausal women were randomized to 12 months of aerobic exercise for 200 min/week (n = 160) or to a control group (n = 160). Intention-to-treat analyses were performed using general linear models with sex hormone concentrations at 6 and 12...