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7 papers found.
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Protein markers and risk of type 2 diabetes and prediabetes: a targeted proteomics approach in the KORA F4/FF4 study

Christine von Toerne as well as Stefanie M. Hauck and Barbara Thorand contributed equally to this work. Electronic supplementary material The online version of this article ( https://doi.org/10.1007/s10654

Peptide serum markers in islet autoantibody-positive children

presymptomatic disease period. Autoantibody-positive; Autoimmunity; BABYDIAB/BABYDIET; LC-MS/MS; Progression time; Risk score; Selected reaction monitoring; Targeted proteomic; Type 1 diabetes - Christine von ... Toerne and Michael Laimighofer contributed equally to this study. Electronic supplementary material The online version of this article (doi:10.1007/s00125-016-4150-x) contains peer-reviewed but unedited

MASP1, THBS1, GPLD1 and ApoA-IV are novel biomarkers associated with prediabetes: the KORA F4 study

monitoring (SRM)-MS to quantify 23 candidate proteins in the plasma of 439 randomly selected men and women Christine von Toerne and Cornelia Huth are joint first authors. Barbara Thorand and Stefanie Hauck are ... joint senior authors. - Christine von Toerne Results Mannan-binding lectin serine peptidase 1 (MASP1; OR per SD 1.77 [95% CI 1.26, 2.47]), thrombospondin 1 (THBS1; OR per SD 1.55 [95% CI 1.16, 2.07

Long-term consequences of in utero irradiated mice indicate proteomic changes in synaptic plasticity related signalling

’ contributions Stefan J. Kempf, Christine von Toerne, and Stefanie M. Hauck performed the proteomic experiment and western blotting, Stefan J. Kempf, Mohammed A. Benotmane, Michael J. Atkinson and Soile Tapio

Ionising Radiation Immediately Impairs Synaptic Plasticity-Associated Cytoskeletal Signalling Pathways in HT22 Cells and in Mouse Brain: An In Vitro/In Vivo Comparison Study

Patients suffering from brain malignancies are treated with high-dose ionising radiation. However, this may lead to severe learning and memory impairment. Preventive treatments to minimise these side effects have not been possible due to the lack of knowledge of the involved signalling pathways and molecular targets. Mouse hippocampal neuronal HT22 cells were irradiated with...

Efficient Isolation of Pure and Functional Mitochondria from Mouse Tissues Using Automated Tissue Disruption and Enrichment with Anti-TOM22 Magnetic Beads

To better understand molecular mechanisms regulating changes in metabolism, as observed e.g. in diabetes or neuronal disorders, the function of mitochondria needs to be precisely determined. The usual isolation methods such as differential centrifugation result in isolates of highly variable quality and quantity. To fulfill the need of a reproducible isolation method from solid...