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15 papers found.
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Individualisierung der antihypertensiven Therapie bei Patienten mit Diabetes mellitus. Leitlinie der Österreichischen Diabetes Gesellschaft (Update 2019)

ZusammenfassungHypertonie ist eine sehr häufige Komorbidität bei Patienten mit Diabetes mellitus, die – wenn unzureichend behandelt – signifikant zur erhöhten Mortalität und zum Auftreten von mikrovaskulären und makrovaskulären Komplikationen beiträgt. Eine Individualisierung der Blutdruckzielwerte in Abhängigkeit vom Patientenalter und vom Vorliegen bestimmter vaskulärer...

Circulating microRNAs -192 and -194 are associated with the presence and incidence of diabetes mellitus

We sought to identify circulating microRNAs as biomarkers of prevalent or incident diabetes. In a pilot study of 18 sex- and age-matched patients with metabolic syndrome, nine of whom developed diabetes during 6 years of follow-up, an array of 372 microRNAs discovered significantly elevated serum levels of microRNAs -122, -192, -194, and -215 in patients who developed diabetes...

Antihyperglykämische Therapie bei Diabetes mellitus Typ 2 (Update 2019)

/Danone, Poxel, sanofi-aventis. Christoph HSaely hat von folgenden Unternehmen, die auch fördernde Mitglieder der ÖDG sind, Forschungsunterstützungen und/oder Honorare erhalten: Amgen, AstraZeneca

Toward a more professional and practical medical education: a novel Central European approach

Toward a more professional and practical medical education: a novel Central European approach Heinz Drexel,1–4,* Alexander Vonbank,1–3,* Peter Fraunberger,3,5 Walter F Riesen,3 Christoph H Saely1–3 1Vorarlberg Institute for Vascular Investigation and Treatment, 2Department of Medicine and Cardiology, Academic Teaching Hospital Feldkirch, Feldkirch, Austria; 3Private University of...

Long-Term Weight Change: Association with Impaired Glucose Metabolism in Young Austrian Adults

Little is known about the associations between long-term weight change and the natural history of impaired fasting glucose (IFG) in young adults. We investigated the association between long-term body mass index (BMI) change and the risk of IFG using data of 24,930 20- to 40-year-old participants from the Vorarlberg Health Monitoring and Promotion Program (VHM&PP) cohort. Poisson...

Insulin resistance is significantly associated with the metabolic syndrome, but not with sonographically proven peripheral arterial disease

Objective Insulin resistance (IR) is the key feature of the metabolic syndrome (MetS); its association with peripheral arterial disease (PAD) is unclear. We hypothesized that IR is associated with both the MetS and sonographically proven PAD. Methods IR was determined by the Homeostasis Model Assessment (HOMA) index in 214 patients with sonographically proven PAD as well as in...

Insulin resistance is significantly associated with the metabolic syndrome, but not with sonographically proven peripheral arterial disease

 Vonbank†1, 2, 3, Christoph H Saely†1, 2, 3, Philipp Rein1, 2, 3 and Heinz Drexel1, 2, 3, 4Email author †Contributed equally Cardiovascular Diabetology201312:106 https://doi.org/10.1186/1475-2840-12 ... the clinical cardiovascular event) than in the development of atherosclerosis (which is visualized by sonography or angiography). Notes Alexander Vonbank, Christoph H Saely contributed equally to

Genome-Wide Association Study Reveals a Polymorphism in the Podocyte Receptor RANK for the Decline of Renal Function in Coronary Patients

Impaired kidney function is a significant health problem and a major concern in clinical routine and is routinely determined by decreased glomerular filtration rate (GFR). In contrast to single assessment of a patients' kidney function providing only limited information on patients' health, serial measurements of GFR clearly improves the validity of diagnosis. The decline of...

Roles of the Metabolic Syndrome, HDL Cholesterol, and Coronary Atherosclerosis in Subclinical Inflammation

OBJECTIVE The metabolic syndrome (MetS) and coronary artery disease (CAD) frequently coincide; their individual contribution to inflammation is unknown.

Bile Acid Metabolites in Serum: Intraindividual Variation and Associations with Coronary Heart Disease, Metabolic Syndrome and Diabetes Mellitus

Bile acids (BAs) regulate glucose and lipid metabolism. In longitudinal and case-control-studies, we investigated the diurnal variation of serum concentrations of the 15 major BAs as well as the biosynthetic precursor 7α-hydroxy-4-cholesten-3-one (C4) and their associations, respectively, with coronary artery disease (CAD), diabetes mellitus type 2 (T2DM), and non-diabetic...

Identification of Hypoxia-Induced Genes in Human SGBS Adipocytes by Microarray Analysis

Hypoxia in adipose tissue is suggested to be involved in the development of a chronic mild inflammation, which in obesity can further lead to insulin resistance. The effect of hypoxia on gene expression in adipocytes appears to play a central role in this inflammatory response observed in obesity. However, the global impact of hypoxia on transcriptional changes in human...

Single Nucleotide Polymorphisms of TCF7L2 Are Linked to Diabetic Coronary Atherosclerosis

Background Coronary artery disease (CAD) shares common risk factors with type 2 diabetes (T2DM). Variations in the transcription factor 7-like 2 (TCF7L2) gene, particularly rs7903146, increase T2DM risk. Potential links between genetic variants of the TCF7L2 locus and coronary atherosclerosis are uncertain. We therefore investigated the association between TCF7L2 polymorphisms...

Adult Treatment Panel III 2001 but Not International Diabetes Federation 2005 Criteria of the Metabolic Syndrome Predict Clinical Cardiovascular Events in Subjects Who Underwent Coronary Angiography

OBJECTIVE—The International Diabetes Federation (IDF) has recently established a worldwide consensus definition of the metabolic syndrome. No prospective data are available on the cardiovascular risk associated with this new metabolic syndrome definition. RESEARCH DESIGN AND METHODS—In a prospective study of 750 coronary patients, we recorded vascular events over 4 years. RESULTS...

Is Atherosclerosis in Diabetes and Impaired Fasting Glucose Driven by Elevated LDL Cholesterol or by Decreased HDL Cholesterol?: Response to Schulze and Hoffmann

particles, and high triglycerides. HEINZ DREXEL, MD1,2 STEFAN ACZEL, MD1,2 THOMAS MARTE, MD1 WERNER BENZER, MD2 PETER LANGER, PHD1 WILLI MOLL, MD3 CHRISTOPH H. SAELY, MD1,2 From the 1Vorarlberg Institute

Is Atherosclerosis in Diabetes and Impaired Fasting Glucose Driven by Elevated LDL Cholesterol or by Decreased HDL Cholesterol?

OBJECTIVE—To evaluate the atherogenicity of lipids in coronary patients with normal fasting glucose (NFG), impaired fasting glucose (IFG), and type 2 diabetes. RESEARCH DESIGN AND METHODS—Serum lipid values, the presence of angiographic coronary artery disease (CAD) at baseline, and the incidence of vascular events over 2.3 years were recorded in 750 consecutive patients...