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Impact of transfusion on patients with sepsis admitted in intensive care unit: a systematic review and meta-analysis

Adrie Antoine Gros Michael Darmon Lila Bouadma 0 Jean‑François Timsit jean‑ 0 0 UMR 1137 ‐ IAME Team 5 - DeSCID: Decision Sciences in Infectious Diseases, Control and Care Inserm/Univ Paris Diderot

Persistent lymphopenia is a risk factor for ICU-acquired infections and for death in ICU patients with sustained hypotension at admission

, Paris, France), Christophe Adrie (ICU, Hôpital Cochin, Paris, France), Michael Darmon (Medical ICU, University hospital St Etienne, France), Corinne Alberti (Robert Debré Hospital, Paris France) and ... Christophe Clec’h (ICU, Hôpital Avicenne, Bobigny, and INSERM U823, Grenoble, France). Investigators of the Outcomerea database Christophe Adrie (ICU, Hôpital Delafontaine, Saint Denis, France and Physiology

Respective impact of implementation of prevention strategies, colonization with multiresistant bacteria and antimicrobial use on the risk of early- and late-onset VAP: An analysis of the OUTCOMEREA network

Garrouste-Orgeas (ICU, Saint-Joseph Hospital, Paris, France); Jean-Ralph Zahar (Infection Control Unit, Angers Hospital, Angers, France); Christophe Adrie (ICU, Delafontaine Hospital, Saint Denis, and ... OUTCOMEREA Database: Christophe Adrie (ICU, Delafontaine Hospital, Saint Denis, and Physiology, Cochin Hospital, Paris, France); Bernard Allaouchiche (ICU, Pierre benite Hospital, Lyon, France); Laurent Argaud

Acute Kidney Injury in Severe Sepsis and Septic Shock in Patients with and without Diabetes Mellitus: A Multicenter Study

(Microbiology Department, Hpital Necker, Paris, France), Christophe Adrie (ICU, Hpital Delafontaine, Saint Denis, France), and Christophe Clech (ICU, Hpital Avicenne, Bobigny, and INSERM U823, Grenoble, France ... , Paris, France). Investigators participating in the Outcomerea database Christophe Adrie (ICU, Hpital Delafontaine, Saint Denis, France), Bernard Allaouchiche (ICU, Edouard Herriot Hospital, Lyon

Decreased Risk of Ventilator-Associated Pneumonia in Sepsis Due to Intra-Abdominal Infection

), Maïté GarrousteOrgeas (ICU Hôpital Saint-Joseph, Paris, France), Jean-Ralph Zahar (Department of Microbiology, Hôpital Necker, Paris, France), Christophe Adrie (Department of Physiology, Hôpital Cochin ... : Christophe Adrie (Department of Physiology, Hôpital Cochin, France), Bernard Allaouchiche (Surgical ICU, Hôpital Edouard Herriot, Lyon), Claire Ara-Somohano (Medical ICU, University Hospital Grenoble France

DNAemia Detection by Multiplex PCR and Biomarkers for Infection in Systemic Inflammatory Response Syndrome Patients

Fast and reliable assays to precisely define the nature of the infectious agents causing sepsis are eagerly anticipated. New molecular biology techniques are now available to define the presence of bacterial or fungal DNA within the bloodstream of sepsis patients. We have used a new technique (VYOO®) that allows the enrichment of microbial DNA before a multiplex polymerase chain...

Initial use of one or two antibiotics for critically ill patients with community-acquired pneumonia: impact on survival and bacterial resistance

Introduction Several guidelines recommend initial empirical treatment with two antibiotics instead of one to decrease mortality in community-acquired pneumonia (CAP) requiring intensive-care-unit (ICU) admission. We compared the impact on 60-day mortality of using one or two antibiotics. We also compared the rates of nosocomial pneumonia and multidrug-resistant bacteria. Methods...

Administration of hydrogen sulfide via extracorporeal membrane lung ventilation in sheep with partial cardiopulmonary bypass perfusion: a proof of concept study on metabolic and vasomotor effects

Introduction Although inhalation of 80 parts per million (ppm) of hydrogen sulfide (H2S) reduces metabolism in mice, doses higher than 200 ppm of H2S were required to depress metabolism in rats. We therefore hypothesized that higher concentrations of H2S are required to reduce metabolism in larger mammals and humans. To avoid the potential pulmonary toxicity of H2S inhalation at...

Administration of hydrogen sulfide via extracorporeal membrane lung ventilation in sheep with partial cardiopulmonary bypass perfusion: a proof of concept study on metabolic and vasomotor effects

Although inhalation of 80 parts per million (ppm) of hydrogen sulfide (H2S) reduces metabolism in mice, doses higher than 200 ppm of H2S were required to depress metabolism in rats. We therefore hypothesized that higher concentrations of H2S are required to reduce metabolism in larger mammals and humans. To avoid the potential pulmonary toxicity of H2S inhalation at high...

Outcome of ICU patients with Clostridium difficile infection

Introduction As data from Clostridium difficile infection (CDI) in intensive care unit (ICU) are still scarce, our objectives were to assess the morbidity and mortality of ICU-acquired CDI. Methods We compared patients with ICU-acquired CDI (watery or unformed stools occurring ≥ 72 hours after ICU admission with a stool sample positive for C. difficile toxin A or B) with two...

Increased nonbeneficial care in patients spending their birthday in the ICU

-Ralph Zahar (Microbiology Department, Ho pital and occurrence of the birthday during the ICU stay. Necker, Paris, France), Christophe Adrie (ICU, Ho pital Moreover, the 4-day difference in ICU length of ... suited to the study hypothesis; the fairly large number of cases and controls; and the matching on sev- Christophe Adrie (ICU, Hopital Delafontaine, Saint eral variables to correct for disease severity

Prognostic consequences of borderline dysnatremia: pay attention to minimal serum sodium change

Introduction To assess the prevalence of dysnatremia, including borderline changes in serum sodium concentration, and to estimate the impact of these dysnatremia on mortality after adjustment for confounders. Methods Observational study on a prospective database fed by 13 intensive care units (ICUs). Unselected patients with ICU stay longer than 48 h were enrolled over a 14-year...

Prognostic consequences of borderline dysnatremia: pay attention to minimal serum sodium change

To assess the prevalence of dysnatremia, including borderline changes in serum sodium concentration, and to estimate the impact of these dysnatremia on mortality after adjustment for confounders. Observational study on a prospective database fed by 13 intensive care units (ICUs). Unselected patients with ICU stay longer than 48 h were enrolled over a 14-year period were included...

Impact of ureido/carboxypenicillin resistance on the prognosis of ventilator-associated pneumonia due to Pseudomonas aeruginosa

, France), Lilia Soufir (ICU, Hpital Saint-Joseph, Paris, France), Jean-Ralph Zahar (Microbiology Department, Hpital Necker, Paris, France), Christophe Adrie (ICU, Hpital Delafontaine, Saint Denis, France ... ), and Didier Nakache (Conservatoire National des Arts et Mtiers, Paris, France), Aurlien Vannieuwenhuyze (Tourcoing, France). Investigators of the Outcomerea database: Christophe Adrie (ICU, Hpital

Severe Hypothermia Increases the Risk for Intensive Care Unit–Acquired Infection

-Joseph, Paris, France), Jean-Ralph Zahar (Microbiology Department, H opital Necker, Paris, France), Christophe Adrie (ICU, Ho pital Delafontaine, Saint Denis, France), Michael Darmon (Medical ICU ... ). Investigators of the OUTCOMEREA Database. Christophe Adrie (ICU, Ho pital Delafontaine, Saint Denis, France and Physiology, Ho pital Cochin, Paris, France), Bernard Allaouchiche (ICU, Edouard Herriot Hospital

Association between hypernatraemia acquired in the ICU and mortality: a cohort study

Background. The aim of this study is to describe the prevalence and outcomes of intensive care unit (ICU)-acquired hypernatraemia (IAH). Methods. A retrospective analysis was performed on a prospectively collected database fed by 12 ICUs. Subjects are unselected patients with ICU stay >48 h. Mild and moderate to severe hypernatraemia were defined as serum sodium >145 and >150...

Model for predicting short-term mortality of severe sepsis

Introduction To establish a prognostic model for predicting 14-day mortality in ICU patients with severe sepsis overall and according to place of infection acquisition and to sepsis episode number. Methods In this prospective multicentre observational study on a multicentre database (OUTCOMEREA) including data from 12 ICUs, 2268 patients with 2737 episodes of severe sepsis were...

Reliability of diagnostic coding in intensive care patients

Introduction Administrative coding of medical diagnoses in intensive care unit (ICU) patients is mandatory in order to create databases for use in epidemiological and economic studies. We assessed the reliability of coding between different ICU physicians. Method One hundred medical records selected randomly from 29,393 cases collected between 1998 and 2004 in the French...

Is Methicillin Resistance Associated with a Worse Prognosis in Staphylococcus aureus Ventilator-Associated Pneumonia?

´ Garrouste-Orgeas 1 13 Samir Jamali 9 13 Bruno Mourvillier 0 13 Arnaud De Lassence 8 13 Adrien Descorps-Declere 2 13 Christophe Adrie 11 13 Marie-Alliette Costa de Beauregard 7 13 Elie Azoulay 6 13 Carole