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Search: authors:"Christopher A. Rinaldi"

8 papers found.
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Pulse Arrival Time and Pulse Interval as Accurate Markers to Detect Mechanical Alternans

Mechanical alternans (MA) is a powerful predictor of adverse prognosis in patients with heart failure and cardiomyopathy, but its use remains limited due to the need of invasive continuous arterial pressure recordings. This study aims to assess novel cardiovascular correlates of MA in the intact human heart to facilitate affordable and non-invasive detection of MA and advance our...

Comparison of Echocardiographic and Electrocardiographic Mapping for Cardiac Resynchronisation Therapy Optimisation

Study hypothesis. We sought to investigate the association between echocardiographic optimisation and ventricular activation time in cardiac resynchronisation therapy (CRT) patients, obtained through the use of electrocardiographic mapping (ECM). We hypothesised that echocardiographic optimisation of the pacing delay between the atrial and ventricular leads—atrioventricular delay...

Understanding non-response to cardiac resynchronisation therapy: common problems and potential solutions

Heart failure is a complex clinical syndrome associated with a significant morbidity and mortality burden. Reductions in left ventricular (LV) function trigger adaptive mechanisms, leading to structural changes within the LV and the potential development of dyssynchronous ventricular activation. This is the substrate targeted during cardiac resynchronisation therapy (CRT...

Chronic Right Ventricular Pacing in the Heart Failure Population

Interest Justin Gould and Bradley Porter are on clinical research fellowship programs funded by Abbott. Baldeep Sidhu is on a clinical research fellowship program funded by Medtronic Inc. Christopher A ... . Rinaldi receives research funding and/or consultancy fees from Abbott, Medtronic Inc., Boston, and LivaNova outside of the submitted work. Human and Animal Rights and Informed Consent This article does not

3D/2D model-to-image registration by imitation learning for cardiac procedures

PurposeIn cardiac interventions, such as cardiac resynchronization therapy (CRT), image guidance can be enhanced by involving preoperative models. Multimodality 3D/2D registration for image guidance, however, remains a significant research challenge for fundamentally different image data, i.e., MR to X-ray. Registration methods must account for differences in intensity, contrast...

Computational Modeling for Cardiac Resynchronization Therapy

health of patients; as well as provide a testing ground for emerging technologies. Compliance with Ethical Standards Conflict of Interest Christopher A Rinaldi has received research grants from Medtronic

Investigating a Novel Activation-Repolarisation Time Metric to Predict Localised Vulnerability to Reentry Using Computational Modelling

Exit sites associated with scar-related reentrant arrhythmias represent important targets for catheter ablation therapy. However, their accurate location in a safe and robust manner remains a significant clinical challenge. We recently proposed a novel quantitative metric (termed the Reentry Vulnerability Index, RVI) to determine the difference between activation and...