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4 papers found.
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Multi-omics discovery of exome-derived neoantigens in hepatocellular carcinoma

variant Varns Non-synonymous somatic variant WES Whole exome sequencing WTlig Wild-type peptide corresponding to PNE with evidence on HLA ligandome level (HLA class I) Markus W. Löffler and Christopher ... Mohr contributed equally to this work. Electronic supplementary material The online version of this article ( contains supplementary material, which is

qPortal: A platform for data-driven biomedical research

Conceptualization: Christopher Mohr, Andreas Friedrich, David Wojnar, Marius Cosmin Codrea, Stefan Czemmel, Oliver Kohlbacher, Sven Nahnsen. Software: Christopher Mohr, Andreas Friedrich, David Wojnar, Erhan Kenar ... . Visualization: Aydin Can Polatkan. Writing ± original draft: Christopher Mohr, Andreas Friedrich, Sven Nahnsen. Writing ± review & editing: Christopher Mohr, Andreas Friedrich, David Wojnar, Erhan Kenar, Aydin

FRED 2: an immunoinformatics framework for Python

Summary: Immunoinformatics approaches are widely used in a variety of applications from basic immunological to applied biomedical research. Complex data integration is inevitable in immunological research and usually requires comprehensive pipelines including multiple tools and data sources. Non-standard input and output formats of immunoinformatics tools make the development of...

OptiType: precision HLA typing from next-generation sequencing data

Motivation: The human leukocyte antigen (HLA) gene cluster plays a crucial role in adaptive immunity and is thus relevant in many biomedical applications. While next-generation sequencing data are often available for a patient, deducing the HLA genotype is difficult because of substantial sequence similarity within the cluster and exceptionally high variability of the loci...