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Search: authors:"Chun-Chen Ho"

3 papers found.
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The role of sentrin-specific protease 2 substrate recognition in TGF-β-induced tumorigenesis

, Ying-Mei Lin, Jen-Chong Jeng, Chun-Chen Ho & Hsiu-Ming ShihThe Ph.D. Program for Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, 11031 ... in:Nature Research journals • PubMed • Google Scholar Search for Chun-Chen Ho in:Nature Research journals • PubMed • Google Scholar Search for Hsiu-Ming Shih in:Nature Research journals • PubMed • Google

Molecular mechanism of K65 acetylation-induced attenuation of Ubc9 and the NDSM interaction

The negatively charged amino acid-dependent sumoylation motif (NDSM) carries an additional stretch of acidic residues downstream of the consensus Ψ-K-x-E/D sumoylation motif. We have previously shown that acetylation of the SUMO E2 conjugase enzyme, Ubc9, at K65 downregulates its binding to the NDSM and renders a selective decrease in sumoylation of substrates with the NDSM motif...