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Geometric isotope effect of deuteration in a hydrogen-bonded host–guest crystal

Deuteration of a hydrogen bond by replacing protium (H) with deuterium (D) can cause geometric changes in the hydrogen bond, known as the geometric H/D isotope effect (GIE). Understanding the GIEs on global structures and bulk properties is of great importance to study structure–property relationships of hydrogen-bonded systems. Here, we report a hydrogen-bonded host–guest...

Knowledge, attitudes, and influencing factors of cancer patients toward approving advance directives in China

PurposeMany cancer patients do not have advance directives (ADs), which may lead to unwanted excessive or aggressive care when patients have lost decision-making capacity. The aim of this study was to investigate knowledge and attitudes of approving ADs and explore factors associated with willing to designate ADs among cancer patients in China.MethodsWe conducted semi-structured...

Diagnostic Value of Mutation-Specific Antibodies for Immunohistochemical Detection of Epidermal Growth Factor Receptor Mutations in Non-Small Cell Lung Cancer: A Meta-Analysis

Background Various studies have assessed the diagnostic accuracy of EGFR mutation-specific antibodies in non-small cell lung cancer (NSCLC). We performed a meta-analysis of existing data to investigate the diagnostic value of mutation-specific antibodies for detection of EGFR mutations in NSCLC. Methods We systematically retrieved relevant studies from PubMed, Web of Knowledge...

The effects of volatile anesthetics on cardiac ischemic complications and mortality in CABG: a meta-analysis

[Les effets des anesthsiques volatils sur les complications ischmiques et la mortalit cardiaques pendant le PAC : une mta-analyse] Chun Hua Yu MD,* W. Scott Beattie MD PhD FRCPC Purpose: Coronary