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Monocyte programmed death ligand-1 expression after 3–4 days of sepsis is associated with risk stratification and mortality in septic patients: a prospective cohort study

Background Septic shock is a major healthcare problem with a high mortality rate that might be caused by immunosuppression. Programmed cell death receptor-1 (PD-1) and programmed cell death receptor ligand-1 (PD-L1), which are co-inhibitory receptor molecules, participate in sepsis-induced immunosuppression. In this study, we investigated which PD-1-related molecules can be used...

Low B and T lymphocyte attenuator expression on CD4 + T cells in the early stage of sepsis is associated with the severity and mortality of septic patients: a prospective cohort study

Introduction B and T lymphocyte attenuator (BTLA) is an inhibitory receptor, whose primary role in CD4 + T cell is thought to inhibit cytokine production. We explore BTLA expression on CD4 + T cells in healthy controls and septic patients, and assess the correlation of BTLA expression on CD4 + T cells in the early stage of sepsis with the severity and mortality of septic patients...

Risk stratification and prognostic performance of the predisposition, infection, response, and organ dysfunction (PIRO) scoring system in septic patients in the emergency department: a cohort study

Yun-Xia Chen 0 Chun-Sheng Li 0 0 Emergency Department of Beijing Chao-Yang Hospital, Affiliated to Capital Medical University , Chaoyang District, Beijing 100020 , China Introduction: The

Effect of continuous compression and 30:2 cardiopulmonary resuscitation on cerebral microcirculation in a porcine model of cardiac arrest

Background The effect of rescue breathing on neurologic prognosis after cardiopulmonary resuscitation (CPR) is controversial. Therefore, we investigated the cerebral microcirculatory and oxygen metabolism during continuous compression (CC) and 30:2 CPR (VC) in a porcine model of cardiac arrest to determine which is better for neurologic prognosis after CPR. Methods After 4 min of...

Load-distributing band improves ventilation and hemodynamics during resuscitation in a porcine model of prolonged cardiac arrest

Shuo Wang 0 Jun-Yuan Wu 0 Chun-Sheng Li 0 0 Department of Emergency Medicine, Beijing Chaoyang Hospital, Affiliated to Capital Medical University , Chaoyang District, Beijing 100020 , China Background

Diagnostic value and prognostic evaluation of Presepsin for sepsis in an emergency department

Introduction Presepsin levels are known to be increased in sepsis. The aim of this study was to evaluate the early diagnostic and prognostic value of Presepsin compared with procalcitonin (PCT), Mortality in Emergency Department Sepsis (MEDS) score and Acute Physiology and Chronic Health Evaluation II (APACHE II) score in septic patients in an emergency department (ED) and to...

Effect of Mild Hypothermia on the Coagulation-Fibrinolysis System and Physiological Anticoagulants after Cardiopulmonary Resuscitation in a Porcine Model

The aim of this study was to evaluate the effect of mild hypothermia on the coagulation-fibrinolysis system and physiological anticoagulants after cardiopulmonary resuscitation (CPR). A total of 20 male Wuzhishan miniature pigs underwent 8 min of untreated ventricular fibrillation and CPR. Of these, 16 were successfully resuscitated and were randomized into the mild hypothermia...

Mild Hypothermia Attenuates Mitochondrial Oxidative Stress by Protecting Respiratory Enzymes and Upregulating MnSOD in a Pig Model of Cardiac Arrest

Mild hypothermia is the only effective treatment confirmed clinically to improve neurological outcomes for comatose patients with cardiac arrest. However, the underlying mechanism is not fully elucidated. In this study, our aim was to determine the effect of mild hypothermia on mitochondrial oxidative stress in the cerebral cortex. We intravascularly induced mild hypothermia (33...