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Rethinking ADHD intervention trials: feasibility testing of two treatments and a methodology

Attention deficit hyperactivity disorder (ADHD) is a lifelong condition associated with considerable costs. The long-term effectiveness and acceptability of treatments to improve outcomes remains in doubt. Long-term trials are needed comparing interventions with standard care and each other. The Sheffield Treatments for ADHD Research (STAR) project used the Trials within Cohorts...

The association between long-term conditions and uptake of population-based screening for colorectal cancer: results from two English cohort studies

The association between long-term conditions and uptake of population-based screening for colorectal cancer: results from two English cohort studies Benjamin Kearns,1 Jim Chilcott,1 Clare Relton,1

Women’s preferences for alternative financial incentive schemes for breastfeeding: A discrete choice experiment

pre-testing stages. 16 / 19 Author Contributions Conceptualization: Frauke Becker, Nana Anokye, Mark Strong, Julia Fox-Rushby. Data curation: Frauke Becker, Nana Anokye, Ailish Higgins, Clare Relton ... , Julia Fox-Rushby. Formal analysis: Frauke Becker, Nana Anokye, Esther W. de Bekker-Grob, Ailish Higgins, Julia Fox-Rushby. Funding acquisition: Clare Relton, Mark Strong, Julia Fox-Rushby. Methodology

Protocol for the development of a CONSORT extension for RCTs using cohorts and routinely collected health data

BackgroundRandomized controlled trials (RCTs) are often complex and expensive to perform. Less than one third achieve planned recruitment targets, follow-up can be labor-intensive, and many have limited real-world generalizability. Designs for RCTs conducted using cohorts and routinely collected health data, including registries, electronic health records, and administrative...

Patterns of multimorbidity and their association with health outcomes within Yorkshire, England: baseline results from the Yorkshire Health Study

by contacting Clare Relton (). Multi-disciplinary collaboration is strongly encouraged. Authors’ contributions CR conceived of the idea for the article and JL and BK helped to focus its research

Corrigendum: Can we deliver randomized trials of focal therapy in prostate cancer?

Nature Reviews Clinical Oncology 0 Hashim U. Ahmed , Viktor Berge, David Bottomley, William Cross, Rakesh Heer, Richard Kaplan, Tom Leslie, Chris Parker, Clare Relton, Richard Stephens, Matthew R

Association between body mass index and health-related quality of life, and the impact of self-reported long-term conditions – cross-sectional study from the south Yorkshire cohort dataset

Background We sought to quantify the relationship between body mass index (BMI) and health-related quality (HRQoL) of life, as measured by the EQ-5D, whilst controlling for potential confounders. In addition, we hypothesised that certain long-term conditions (LTCs), for which being overweight or obese is a known risk factor, may mediate the association between BMI and HRQoL...

Examining the impact of 11 long-standing health conditions on health-related quality of life using the EQ-5D in a general population sample

(ScHARR) Ethics Committee at the University of Sheffield. This study is funded by a National Institute for Health Research (NIHR) Methodology Fellowship. We would like to thank Clare Relton and her

Examining the incremental impact of long-standing health conditions on subjective well-being alongside the EQ-5D

) Methodology Fellowship. We would like to thank Allan Wailoo for suggestions and Clare Relton and her colleagues at the University of Sheffield for undertaking the SYC cohort health and weight study, which was

Deprivation, clubs and drugs: results of a UK regional population-based cross-sectional study of weight management strategies

Background Despite rising levels of obesity in England, little is known about slimming club and weight loss drug (medication) use or users. In order to inform future commissioning, we report the prevalence of various weight management strategies and examine the associations between slimming club and medication use and age, gender, deprivation and body mass index. Methods A...

The ‘Pounds for Pounds’ weight loss financial incentive scheme: an evaluation of a pilot in NHS Eastern and Coastal Kent

weight loss,8 – 12 but evidence regarding the optimal size and duration of incentive required to yield a †Clare Relton and Mark Strong contributed equally to this work. clinically important and sustained

Healthcare providers’ views on the acceptability of financial incentives for breastfeeding: a qualitative study

Background Despite a gradual increase in breastfeeding rates, overall in the UK there are wide variations, with a trend towards breastfeeding rates at 6–8 weeks remaining below 40% in less affluent areas. While financial incentives have been used with varying success to encourage positive health related behaviour change, there is little research on their use in encouraging...

South Yorkshire Cohort: a 'cohort trials facility' study of health and weight - Protocol for the recruitment phase

Background Growing levels of both obesity and chronic disease in the general population pose a major public health problem. In the UK, an innovative 'health and weight' cohort trials facility, the 'South Yorkshire Cohort', is being built in order to provide robust evidence to inform policy, commissioning and clinical decisions in this field. This protocol reports the design of...