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Serum resistin is causally related to mortality risk in patients with type 2 diabetes: preliminary evidences from genetic data

De Bonis Lucia Salvemini Salvatore De Cosmo Mauro Cignarelli Massimiliano Copetti Vincenzo Trischitta Claudia Menzaghi OPEN Published: xx xx xxxx Resistin has been firmly associated with all-cause ... equally to this work. Vincenzo Trischitta and Claudia Menzaghi jointly supervised this work. Correspondence and requests for materials should be addressed to V.T. (email: ) or C.M. (email: c.menzaghi

Evidence of a causal relationship between high serum adiponectin levels and increased cardiovascular mortality rate in patients with type 2 diabetes

Background Despite its beneficial role on insulin resistance and atherosclerosis, adiponectin has been repeatedly reported as an independent positive predictor of cardiovascular mortality. Methods A Mendelian randomization approach was used, in order to evaluate whether such counterintuitive association recognizes a cause-effect relationship. To this purpose, single nucleotide...

Serum Adiponectin and Glomerular Filtration Rate in Patients with Type 2 Diabetes

High serum adiponectin has been increased in several conditions of kidney disease. Only sparse and conflicting results have been reported in patients with type 2 diabetes (T2D), a subgroup of individuals who are at high risk for renal dysfunction. The aim of this study was to fill up this gap of knowledge by investigating such association in a large sample of Italian diabetic...

Serum Resistin and Glomerular Filtration Rate in Patients with Type 2 Diabetes

Background High serum levels of the pro-inflammatory adipokine resistin have been associated with decreased renal function in the general population. The goal of this study was to investigate whether such association is also present among diabetic subjects, who are at increased risk of renal function loss. Methods The cross-sectional association between serum resistin levels and...

Association between Resistin Levels and All-Cause and Cardiovascular Mortality: A New Study and a Systematic Review and Meta-Analysis

could be send to: Claudia Menzaghi, PhD or Vincenzo Trischitta, MD Research Unit of Diabetes and Endocrine Diseases IRCCS Casa Sollievo della Sofferenza Viale Padre Pio, 71013 San Giovanni Rotondo, Italy

GALNT2 Expression Is Reduced in Patients with Type 2 Diabetes: Possible Role of Hyperglycemia

Impaired insulin action plays a major role in the pathogenesis of type 2 diabetes, a chronic metabolic disorder which imposes a tremendous burden to morbidity and mortality worldwide. Unraveling the molecular mechanisms underlying insulin resistance would improve setting up preventive and treatment strategies of type 2 diabetes. Down-regulation of GALNT2, an UDPN-acetyl-alpha-D...

Circulating adiponectin and cardiovascular mortality in patients with type 2 diabetes mellitus: evidence of sexual dimorphism

Background The pathogenesis of cardiovascular (CV) mortality, whose rate is increased in type 2 diabetes, is poorly understood. While high serum adiponectin is associated with increased CV mortality in the general population, no data are available in type 2 diabetes. We here investigated whether this counterintuitive association was observable also in diabetic patients and...

Novel Locus FER Is Associated With Serum HMW Adiponectin Levels

Lu Qi Claudia Menzaghi Lucia Salvemini Concetta De Bonis Vincenzo Trischitta Frank B. Hu OBJECTIVEHigh molecular weight (HMW) adiponectin is a predominant isoform of circulating adiponectin and has

Genetic Influences of Adiponectin on Insulin Resistance, Type 2 Diabetes, and Cardiovascular Disease

Claudia Menzaghi Vincenzo Trischitta Alessandro Doria Recent evidence points to molecules secreted by the adipose tissue, or adipokines, as possible links between increased adipose mass and

Development and Validation of a Predicting Model of All-Cause Mortality in Patients With Type 2 Diabetes

PHD CLAUDIA MENZAGHI PHD MAURO CIGNARELLI FABIO PELLEGRINI MSC VINCENZO TRISCHITTA C a r d i o v a s c u l a r a n d OBJECTIVEdTo develop and validate a parsimonious model for predicting short-term

Serum Resistin and Kidney Function: A Family-Based Study in Non-Diabetic, Untreated Individuals

Background High serum resistin levels have been associated with kidney dysfunction. Most of these studies have been carried out in individuals with severe kidney impairment, diabetes, cardiovascular disease and related treatments. Thus, the observed association might have been influenced by these confounders. Our aim was to study the relationship between serum resistin, urinary...

Serum Resistin, Cardiovascular Disease and All-Cause Mortality in Patients with Type 2 Diabetes

Background High serum resistin has been associated with increased risk of cardiovascular disease in the general population, Only sparse and conflicting results, limited to Asian individuals, have been reported, so far, in type 2 diabetes. We studied the role of serum resistin on coronary artery disease, major cardiovascular events and all-cause mortality in type 2 diabetes...

Genome-wide association analysis identifies TYW3/CRYZ and NDST4 loci associated with circulating resistin levels

Qibin Qi 5 Claudia Menzaghi 3 Shelly Smith 10 Liming Liang 4 Nathalie de Rekeneire 7 Melissa E. Garcia 8 Kurt K. Lohman 10 Iva Miljkovic 12 Elsa S. Strotmeyer 12 Steve R. Cummings 11 Alka M. Kanaya

The +276 G/T Single Nucleotide Polymorphism of the Adiponectin Gene Is Associated With Coronary Artery Disease in Type 2 Diabetic Patients

SIMONETTA BACCI CLAUDIA MENZAGHI PHD TONINO ERCOLINO XIAOWEI MA ANNA RAUSEO LUCIA SALVEMINI BSC OBJECTIVE - Two single nucleotide polymorphisms (SNPs) at the adiponectin locus (45TG and 276GT) have

A Haplotype at the Adiponectin Locus Is Associated With Obesity and Other Features of the Insulin Resistance Syndrome

Adiponectin is a protein secreted by adipocytes that modulates insulin action. To assess whether variants of this gene contribute to the prevalence of insulin resistance in Caucasians, we genotyped 413 nondiabetic individuals for two single nucleotide polymorphisms (SNPs) at this locus. The two SNPs (45T→G and 276G→T) were chosen because of their association with type 2 diabetes...

The K121Q Polymorphism of the ENPP1/PC-1 Gene Is Associated With Insulin Resistance/Atherogenic Phenotypes, Including Earlier Onset of Type 2 Diabetes and Myocardial Infarction

Insulin resistance (IR) is pathogenic for type 2 diabetes and coronary artery disease (CAD). The K121Q polymorphism of the ENPP1/PC-1 gene is associated with IR. Our aim was to investigate the role of the 121Q variant on the risk of type 2 diabetes and CAD. Nondiabetic control subjects (n = 638), type 2 diabetic patients without CAD (n = 535), and type 2 diabetic patients with...

A common haplotype at the CD36 locus is associated with high free fatty acid levels and increased cardiovascular risk in Caucasians

Xiaowei Ma Simonetta Bacci Wojciech Mlynarski Lucia Gottardo Teresa Soccio Claudia Menzaghi Elisabetta Iori Robert A. Lager Adhir R. Shroff Ernest V. Gervino Richard W. Nesto Michael T. Johnstone