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Clifford R. Jack Jr. 0 ) Department of Radiology, Mayo Clinic and Foundation , 200 First Street SW, Rochester, MN 55905 , USA - The condition described by Crary et al. [5] of predominantly medial

Pittsburgh compound B (PiB) PET imaging of meningioma and other intracranial tumors

Meningiomas are the most common intracranial tumors. Diagnosis by MRI is generally straightforward, but lack of imaging specificity can present a diagnostic dilemma, particularly in patients with cancer. We report our experience with meningioma identification on Pittsburgh compound B (PiB) PET/CT. Patients who underwent PiB PET/CT from 2006 to 2015 were reviewed to identify those...

On the path to 2025: understanding the Alzheimer’s disease continuum

Basic research advances in recent years have furthered our understanding of the natural history of Alzheimer’s disease (AD). It is now recognized that pathophysiological changes begin many years prior to clinical manifestations of disease and the spectrum of AD spans from clinically asymptomatic to severely impaired. Defining AD purely by its clinical presentation is thus...

Drug development in Alzheimer’s disease: the path to 2025

The global impact of Alzheimer’s disease (AD) continues to increase, and focused efforts are needed to address this immense public health challenge. National leaders have set a goal to prevent or effectively treat AD by 2025. In this paper, we discuss the path to 2025, and what is feasible in this time frame given the realities and challenges of AD drug development, with a focus...

Aortic hemodynamics and white matter hyperintensities in normotensive postmenopausal women

and Biomedical Engineering, Mayo Clinic , Rochester, MN , USA 9 Michael J. Joyner 10 Clifford R. Jack Jr 11 Virginia M. Miller , USA 12 Lynne T. Shuster Hypertension is associated with development of

Clinicopathologic assessment and imaging of tauopathies in neurodegenerative dementias

Microtubule-associated protein tau encoded by the MAPT gene binds to microtubules and is important for maintaining neuronal morphology and function. Alternative splicing of MAPT pre-mRNA generates six major tau isoforms in the adult central nervous system resulting in tau proteins with three or four microtubule-binding repeat domains. In a group of neurodegenerative disorders...

Role of structural MRI in Alzheimer's disease

Atrophy measured on structural magnetic resonance imaging (sMRI) is a powerful biomarker of the stage and intensity of the neurodegenerative aspect of Alzheimer's disease (AD) pathology. In this review, we will discuss the role of sMRI as an AD biomarker by summarizing (a) the most commonly used methods to extract information from sMRI images, (b) the different roles in which...

Effects of Baseline CSF α-Synuclein on Regional Brain Atrophy Rates in Healthy Elders, Mild Cognitive Impairment and Alzheimer’s Disease

BackgroundCerebrospinal fluid (CSF) α-synuclein is reduced in synucleinopathies, including dementia with Lewy bodies, and some studies have found increased CSF α-synuclein in Alzheimer’s disease (AD). No study has explored effects of CSF α-synuclein on brain atrophy. Here we tested if baseline CSF α-synuclein affects brain atrophy rates and if these effects vary across brain...

Untreated Type 2 Diabetes and Its Complications Are Associated With Subcortical Infarctions


Amyloid pathway-based candidate gene analysis of [11C]PiB-PET in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) cohort

Amyloid imaging with [11 C]Pittsburgh Compound-B (PiB) provides in vivo data on plaque deposition in those with, or at risk for, Alzheimer’s disease (AD). We performed a gene-based association analysis of 15 quality-controlled amyloid-pathway associated candidate genes in 103 Alzheimer’s Disease Neuroimaging Initiative participants. The mean normalized PiB uptake value across...

Large-scale genomics unveil polygenic architecture of human cortical surface area

, USA.Ronald Petersen, Clifford R. Jack Jr, Matthew Bernstein, Bret Borowski, Jeff Gunter, Matt Senjem, Prashanthi Vemuri, David Jones, Kejal Kantarci & Chad WardUC Berkeley, Berkeley, CA 94720-5800, USA.William ... , Sarah Murray, Cinnamon Bloss, Mark Appelbaum, Anthony Gamst, Wesley Thompson & Hauke BartschAlzheimer’s Disease Neuroimaging InitiativeMichael Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack Jr

Longitudinal measurement and hierarchical classification framework for the prediction of Alzheimer’s disease

, USARonald Petersen, Clifford R. Jack Jr., Sara S. Mason, Colleen S. Albers, David Knopman & Kris JohnsonUniversity of California, Berkeley, USAWilliam JagustUniversity of Pennsylvania, Pennsylvania, USAJohn Q ... FargherConsortiaThe Alzheimer’s Disease Neuroimaging InitiativeMichael W. Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack Jr., William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green

Effect of CLU genetic variants on cerebrospinal fluid and neuroimaging markers in healthy, mild cognitive impairment and Alzheimer’s disease cohorts

1 0 Consortia Alzheimer?s Disease Neuroimaging Initiative Michael W. Weiner6; Paul Aisen7; Ronald Petersen8,9; Clifford R. Jack, Jr.9; William Jagust10; John Q. Trojanowki11; Arthur W. Toga 12

Genetic studies of plasma analytes identify novel potential biomarkers for several complex traits

, Chiadi Onyike, Daniel D’Agostino & Stephanie KielbMayo Clinic, JacksonvilleNeill R Graff-Radford, Francine Parfitt, Tracy Kendall & Heather JohnsonMayo Clinic, RochesterRonald Petersen, Clifford R. Jack Jr ... Graff-Radford, Francine Parfitt, Tracy Kendall, Heather Johnson, Ronald Petersen, Clifford R. Jack Jr., Matthew Bernstein, Bret Borowski, Jeff Gunter, Matt Senjem, Prashanthi Vemuri, David Jones, Kejal

Ferritin levels in the cerebrospinal fluid predict Alzheimer’s disease outcomes and are regulated by APOE

, Clifford R. Jack Jr., Matthew Bernstein, Bret Borowski, Jeff Gunter, Matt Senjem, Prashanthi Vemuri, David Jones, Kejal Kantarci, Chad Ward, Sara S. Mason, Colleen S. Albers, David Knopman & Kris JohnsonUC ... , Ronald Petersen, Clifford R. Jack Jr., William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John Morris, Leslie M. Shaw, Zaven Khachaturian, Greg Sorensen