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Pooled Segregant Sequencing Reveals Genetic Determinants of Yeast Pseudohyphal Growth

The pseudohyphal growth response is a dramatic morphological transition and presumed foraging mechanism wherein yeast cells form invasive and surface-spread multicellular filaments. Pseudohyphal growth has been studied extensively as a model of conserved signaling pathways controlling stress responses, cell morphogenesis, and fungal virulence in pathogenic fungi. The genetic...

TEAK: Topology Enrichment Analysis frameworK for detecting activated biological subpathways

To mine gene expression data sets effectively, analysis frameworks need to incorporate methods that identify intergenic relationships within enriched biologically relevant subpathways. For this purpose, we developed the Topology Enrichment Analysis frameworK (TEAK). TEAK employs a novel in-house algorithm and a tailor-made Clique Percolation Method to extract linear and nonlinear...

Studying forced expiratory volume at 1 second over menstrual segments in asthmatic and non-asthmatic women: assessing protocol feasibility

Background Sex hormones may play an important role in observed gender differences in asthma incidence and severity, as well as in the observed changes in asthma symptoms during times of hormonal fluctuation (i.e.; premenstrual, pregnancy, etc.). This pilot study sought to demonstrate the feasibility of data collection methods to investigate the effects of sex hormones on lung...

How Accurately Do Young Adults Recall Childhood Pets? A Validation Study

of Biostatistics and Research Epidemiology, Henry Ford Health System, Detroit, Michigan (Charlotte Nicholas, Ganesa Wegienka, Suzanne Havstad, Christine Cole Johnson); Division of Allergy and Clinical

A Large-Scale Complex Haploinsufficiency-Based Genetic Interaction Screen in Candida albicans: Analysis of the RAM Network during Morphogenesis

The morphogenetic transition between yeast and filamentous forms of the human fungal pathogen Candida albicans is regulated by a variety of signaling pathways. How these pathways interact to orchestrate morphogenesis, however, has not been as well characterized. To address this question and to identify genes that interact with the Regulation of Ace2 and Morphogenesis (RAM...

Gender Differences in Total and Allergen-specific Immunoglobulin E (IgE) Concentrations in a Population-based Cohort from Birth to Age Four Years

to Dr. Christine Cole Johnson, Henry Ford Health Sciences Center , 1 Ford Place, 3E, Detroit, Ml 48202 1 Division of Biostatistics and Research Epidemiology, Henry Ford Health System , Detroit, Ml 2

Is Shorter Always Better? Relative Importance of Questionnaire Length and Cognitive Ease on Response Rates and Data Quality for Two Dietary Questionnaires

In this study, the authors sought to determine the effects of length and clarity on response rates and data quality for two food frequency questionnaires (FFQs): the newly developed 36-page Diet History Questionnaire (DHQ), designed to be cognitively easier for respondents, and a 16-page FFQ developed earlier for the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening...