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Modifying effect of metabotype on diet–diabetes associations

PurposeInter-individual metabolic differences may be a reason for previously inconsistent results in diet–diabetes associations. We aimed to investigate associations between dietary intake and diabetes for metabolically homogeneous subgroups (‘metabotypes’) in a large cross-sectional study.MethodsWe used data of 1517 adults aged 38–87 years from the German population-based KORA...

Incidence Rates of Type 2 Diabetes in People With Impaired Fasting Glucose (ADA vs. WHO Criteria) and Impaired Glucose Tolerance: Results From an Older Population (KORA S4/F4/FF4 Study)

The American Diabetes Association (ADA) Expert Committee introduced impaired fasting glucose (IFG: 100–125 mg/dL [5.6–6.9 mmol/L]) as a category with an increased risk for diabetes (1). The World Health Organization (WHO) defined a higher IFG cut point of 110 mg/dL (6.1 mmol/L) because using the lower cut point would substantially increase IFG prevalence and there was no evidence...

Protein markers and risk of type 2 diabetes and prediabetes: a targeted proteomics approach in the KORA F4/FF4 study

apoE improved type 2 diabetes prediction beyond non-invasive risk factors or HbA1c, age and sex. KeywordsType 2 diabetes Prediabetes Population-based Biomarker Proteomics Prediction  Cornelia Huth and

Quality of Diabetes Care in Germany Improved from 2000 to 2007 to 2014, but Improvements Diminished since 2007. Evidence from the Population-Based KORA Studies

Objective Little is known about the development of the quality of diabetes care in Germany. The aim of this study is to analyze time trends in patient self-management, physician-delivered care, medication, risk factor control, complications and quality of life from 2000 to 2014. Methods Analyses are based on data from individuals with type 2 diabetes of the population-based KORA...

Inverse associations between serum levels of secreted frizzled-related protein-5 (SFRP5) and multiple cardiometabolic risk factors: KORA F4 study

Secreted frizzled-related protein (Sfrp)5 has beneficial effects on insulin sensitivity, inflammation and cardiovascular risk in different mouse models, but its relevance for cardiometabolic diseases in humans is controversial. We aimed to characterise associations of circulating SFRP5 with cardiometabolic risk factors and prediabetes/type 2 diabetes in a large population-based...

Perceived risk of diabetes seriously underestimates actual diabetes risk: The KORA FF4 study

Michael Roden 1 Anne Quante Rolf Holle Cornelia Huth Annette Peters Christa Meisinger ☯ These authors contributed equally to this work. Massimo Pietropaolo, Baylor College of Medicine, UNITED STATES 0

Intake of Vitamin and Mineral Supplements and Longitudinal Association with HbA1c Levels in the General Non-Diabetic Population—Results from the MONICA/KORA S3/F3 Study

Background Lower levels of hemoglobin A1c (HbA1c) are associated with a decreased risk of cardiovascular complications in diabetic and non-diabetic individuals. The aim of the study was to longitudinally investigate the association between the use of 11 vitamins and minerals (vitamins E, C, D, B1, folic acid, carotenoids, calcium, magnesium, zinc, iron, and selenium) and change...

MASP1, THBS1, GPLD1 and ApoA-IV are novel biomarkers associated with prediabetes: the KORA F4 study

monitoring (SRM)-MS to quantify 23 candidate proteins in the plasma of 439 randomly selected men and women Christine von Toerne and Cornelia Huth are joint first authors. Barbara Thorand and Stefanie Hauck are

Association of subclinical inflammation with deterioration of glycaemia before the diagnosis of type 2 diabetes: the KORA S4/F4 study

Aims/hypothesis The role of biomarkers of subclinical inflammation in the early deterioration of glycaemia before type 2 diabetes is largely unknown. We hypothesised that increased levels of circulating proinflammatory biomarkers and decreased circulating adiponectin would be associated with 7 year increases of HbA1c in non-diabetic individuals. Methods This study was based on...

Retinol-Binding Protein 4 Is Associated With Prediabetes in Adults From the General Population: The Cooperative Health Research in the Region of Augsburg (KORA) F4 Study

CHRISTA MEISINGER INA M. RCKERT WOLFGANG RATHMANN MSPH ANGELA DRING BARBARA THORAND PHD CORNELIA HUTH PHD MSE BERND KOWALL PHD WOLFGANG KOENIG C a r d i o v a s c u l a r a n d OBJECTIVE-We examined

Effect of Serum 25-Hydroxyvitamin D on Risk for Type 2 Diabetes May Be Partially Mediated by Subclinical Inflammation: Results from the MONICA/KORA Augsburg study

BARBARA THORAND PHD ASTRID ZIERER DIPL STAT CORNELIA HUTH PHD JAKOB LINSEISEN PHD CHRISTA MEISINGER MICHAEL RODEN ANNETTE PETERS PHD WOLFGANG KOENIG CHRISTIAN HERDER PHD C a r d i o v a s c u l a r

Acute-Phase Serum Amyloid A Protein and Its Implication in the Development of Type 2 Diabetes in the KORA S4/F4 Study

OBJECTIVE We sought to investigate whether elevated levels of acute-phase serum amyloid A (A-SAA) protein precede the onset of type 2 diabetes independently of other risk factors, including parameters of glucose metabolism.

Age at Menarche and Its Association with the Metabolic Syndrome and Its Components: Results from the KORA F4 Study

Objective The metabolic syndrome is a major public health challenge and identifies persons at risk for diabetes and cardiovascular disease. The aim of this study was to examine the association between age at menarche and the metabolic syndrome (IDF and NCEP ATP III classification) and its components. Design 1536 women aged 32 to 81 years of the German population based KORA F4...

Plasma Metabolomics Reveal Alterations of Sphingo- and Glycerophospholipid Levels in Non-Diabetic Carriers of the Transcription Factor 7-Like 2 Polymorphism rs7903146

Aims/HypothesisPolymorphisms in the transcription factor 7-like 2 (TCF7L2) gene have been shown to display a powerful association with type 2 diabetes. The aim of the present study was to evaluate metabolic alterations in carriers of a common TCF7L2 risk variant. MethodsSeventeen non-diabetic subjects carrying the T risk allele at the rs7903146 TCF7L2 locus and 24 subjects...

Estimating the Single Nucleotide Polymorphism Genotype Misclassification From Routine Double Measurements in a Large Epidemiologic Sample

Previously, estimation of genotype misclassification of single nucleotide polymorphisms (SNPs) as encountered in epidemiologic practice and involving thousands of subjects was lacking. The authors collected representative data on approximately 14,000 subjects from 8 studies and 646,558 genotypes assessed in 2005 by means of matrix-assisted laser desorption ionization time-of...

1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function

WaldenbergerInstitute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, 85764 Neuherberg, GermanyChristian Gieger, Cornelia Huth, Christa Meisinger ... Frank B. Hu in:Nature Research journals • PubMed • Google ScholarSearch for Cornelia Huth in:Nature Research journals • PubMed • Google ScholarSearch for Nina Hutri-Kähönen in:Nature Research journals

Genome-Wide Association Study to Identify Common Variants Associated with Brachial Circumference: A Meta-Analysis of 14 Cohorts

Huffman Cornelia Huth Alan L. James Norman Klopp Ivana Kolcic Zolta n Kutalik Debbie A. Lawlor Arthur W. Musk Marina Pehlic Craig E. Pennell John R. B. Perry Annette Peters Ozren Polasek Beate St Pourcain ... LMUinnovativ (http://www.mc-health.uni-muenchen.de). Cornelia Huth was supported by a grant from the German Federal Ministry of Education and Research (BMBF) to the German Center for Diabetes Research (DZD e.V

IL6 Gene Promoter Polymorphisms and Type 2 Diabetes: Joint Analysis of Individual Participants’ Data From 21 Studies

Cornelia Huth Iris M. Heid Caren Vollmert Christian Gieger Harald Grallert Johanna K. Wolford Birgit Langer Barbara Thorand Norman Klopp Yasmin H. Hamid Oluf Pedersen Torben Hansen Valeriya Lyssenko