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HPV16 Down-Regulates the Insulin-Like Growth Factor Binding Protein 2 to Promote Epithelial Invasion in Organotypic Cultures

Cervical cancer is a multi-stage disease caused by human papillomaviruses (HPV) infection of cervical epithelial cells, but the mechanisms regulating disease progression are not clearly defined. Using 3-dimensional organotypic cultures, we demonstrate that HPV16 E6 and E7 proteins alter the secretome of primary human keratinocytes resulting in local epithelial invasion...

HPV vaccination impact on a cervical cancer screening program: methods of the FASTER-Tlalpan Study in Mexico

Xavier Bosch, PhD 4   Jack Cuzick, PhD 5   Attila Lörincz, PhD 5   Cosette M Wheeler, PhD 6   Philip E Castle, PhD 7   Claudia Robles, PhD 4   Eduardo Lazcano-Ponce, DSc 2   1

HPV vaccination impact on a cervical cancer screening program: methods of the FASTER-Tlalpan Study in Mexico

Xavier Bosch, PhD 4   Jack Cuzick, PhD 5   Attila Lörincz, PhD 5   Cosette M Wheeler, PhD 6   Philip E Castle, PhD 7   Claudia Robles, PhD 4   Eduardo Lazcano-Ponce, DSc 2   1

No Evidence for Synergy Between Human Papillomavirus Genotypes for the Risk of High-Grade Squamous Intraepithelial Lesions in a Large Population-Based Study

Mexico Health Sciences Center and Tricore Reference Laboratories, Albuquerque, New Mexico; Walter Kinney, MD, Kaiser Permanente Northern California; Cosette M. Wheeler, PhD, University of New Mexico Health

Age-specific prevalence of human papilloma virus infection among Nigerian women

Background Inconsistent trends in HPV prevalence by age have been described in Africa. We examined the age prevalence pattern and distribution of 37 HPV-DNA types among urban Nigerian women. Methods The study population was a sample of 278 women who presented to cervical cancer screening programs in Abuja, Nigeria, between April and August 2012. Using a nurse administered...

HIV associated high-risk HPV infection among Nigerian women

Background In developed countries, the incidence of cervical cancer has remained stable in HIV+ women but the prevalence and multiplicity of high-risk HPV (hrHPV) infection, a necessary cause of cervical cancer, appears different comparing HIV+ to HIV- women. Little is known about HIV and HPV co-infection in Africa. Methods We enrolled women presenting at our cervical cancer...

RPS19 and TYMS SNPs and Prevalent High Risk Human Papilloma Virus Infection in Nigerian Women

High risk HPV (hrHPV) infection is a necessary cause of cervical cancer but the host genetic determinants of infection are poorly understood. We enrolled 267 women who presented to our cervical cancer screening program in Abuja, Nigeria between April 2012 and August 2012. We collected information on demographic characteristics, risk factors of cervical cancer and obtained samples...

Impact of Improved Classification on the Association of Human Papillomavirus With Cervical Precancer

Genetics and Microbiology and of Obstetrics and Gynecology, School of Medicine, University of New Mexico Health Sciences Center , Albuquerque, New Mexico (Cosette M. Wheeler); and Departments of Epide

Variation in Screening Abnormality Rates and Follow-Up of Breast, Cervical and Colorectal Cancer Screening within the PROSPR Consortium

Kim 11 Anne Marie McCarthy 12 Virginia P. Quinn 13 V. Paul Doria-Rose Cosette M. Wheeler 15 William E. Barlow 16 Mackenzie Bronson 7 Michael Garcia Douglas A. Corley 0 Jennifer S. Haas Ethan A. Halm 2

Human Papillomavirus Genotype Distributions: Implications for Vaccination and Cancer Screening in the United States

Background Limited data are available describing human papillomavirus (HPV) genotype distributions in cervical cancer in the United States. Such studies are needed to predict how HPV vaccination and HPV-based screening will influence cervical cancer prevention.

Risk of first cervical HPV infection and pre-cancerous lesions after onset of sexual activity: analysis of women in the control arm of the randomized, controlled PATRICIA trial

trial Xavier Castellsagu Jorma Paavonen Unnop Jaisamrarn Cosette M Wheeler S Rachel Skinner Matti Lehtinen Paulo Naud Song-Nan Chow Maria Rowena Del Rosario-Raymundo Julio C Teixeira Johanna Palmroth

Risk of Cervical Intraepithelial Neoplasia Grade 2 or 3 after Loop Electrosurgical Excision Procedure Associated with Human Papillomavirus Type 16 Variants

Identification of factors associated with risk of relapse after treatment for high-grade cervical intraepithelial neoplasia (CIN) has important clinical implications. Study subjects were women participating in the Atypical Squamous Cells of Undetermined Significance and Low-Grade Squamous Intraepithelial Lesion Triage Study who were treated for CIN3 by loop electrosurgical...

Human Papillomavirus DNA Remains Detectable Longer than Related Cervical Cytologic Abnormalities

Cervical human papillomavirus (HPV) infections are at high risk of neoplastic progression if they persist. Persistence can be measured by repeated HPV DNA tests or by cytologic testing. Thus, it is useful to understand the relationship between these 2 measurements. To explore the relative timing of HPV DNA clearance versus cytologic regression, data were analyzed from 840 study...

Influence of Loop Electrosurgical Excision Procedure on Subsequent Acquisition of New Human Papillomavirus Infections

BackgroundThe impact of loop electrosurgical excision procedure (LEEP) treatment for cervical precancerous lesions on subsequent acquisition of new human papillomavirus (HPV) infections is not well described MethodsThe acquisition of new HPV infections was compared in HPV-positive women who underwent colposcopy and were treated by LEEP (n = 195) and those who were untreated (n...

Variation in HLA Class I Antigen-Processing Genes and Susceptibility to Human Papillomavirus Type 16—Associated Cervical Cancer

Background. Persistent infection with human papillomavirus type 16 (HPV16) is a primary etiological factor for the development of cervical cancer. Genes involved in antigen processing influence both the repertoire of antigens presented by HPV16-infected cells and the nature of HPV16-specific immune responses. Genetic variation in these genes may affect protein structure and...

Human Papillomavirus Type 16 Infections and 2-Year Absolute Risk of Cervical Precancer in Women With Equivocal or Mild Cytologic Abnormalities

Background: The 2-year absolute risk for cervical precancer attributable to infection by human papillomavirus type 16 (HPV16), the most common and oncogenic HPV type, in the millions of women diagnosed annually with equivocal or mildly abnormal cytology has not been definitively evaluated. Methods: Baseline cervical specimens of 5060 women with equivocal (atypical squamous cells...

Human Papillomavirus Type 16 and 18 Variants: Race-Related Distribution and Persistence

Background: Analogous to the geographic distribution of variants of human papillomavirus (HPV) types, the distribution and persistence of these variants among infected individuals may be related to the racial composition of a population living in one geographic region. Methods: We studied 1114 women in the United States participating in the Atypical Squamous Cells of Undetermined...

Risk of Newly Detected Infections and Cervical Abnormalities in Women Seropositive for Naturally Acquired Human Papillomavirus Type 16/18 Antibodies: Analysis of the Control Arm of PATRICIA

Background. We examined risk of newly detected human papillomavirus (HPV) infection and cervical abnormalities in relation to HPV type 16/18 antibody levels at enrollment in PATRICIA (Papilloma Trial Against Cancer in Young Adults; NCT00122681). Methods. Using Poisson regression, we compared risk of newly detected infection and cervical abnormalities associated with HPV-16/18...

Human Papillomavirus Genotypes and the Cumulative 2-Year Risk of Cervical Precancer

BackgroundProspective data on the risks of cervical precancer associated with specific human papillomavirus (HPV) genotypes are limited MethodsIn 5060 women participating in the Atypical Squamous Cells of Undetermined Significance/Low-Grade Squamous Intraepithelial Lesions Triage Study (ALTS), we determined the cumulative 2-year risks of cervical intraepithelial neoplasia (CIN...