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SIRT3 deficiency leads to induction of abnormal glycolysis in diabetic kidney with fibrosis

in:Nature Research journals • PubMed • Google Scholar Search for Keizo Kanasaki in:Nature Research journals • PubMed • Google Scholar Search for Daisuke Koya in:Nature Research journals • PubMed • Google ... or Daisuke Koya. Electronic supplementary material Supplemental Materials Rights and permissions Open Access This article is licensed under a Creative Commons Attribution 4.0 International

The Japanese Clinical Practice Guideline for acute kidney injury 2016

Acute kidney injury (AKI) is a syndrome which has a broad range of etiologic factors depending on different clinical settings. Because AKI has significant impacts on prognosis in any clinical settings, early detection and intervention are necessary to improve the outcomes of AKI patients. This clinical guideline for AKI was developed by a multidisciplinary approach with...

The Japanese Clinical Practice Guideline for acute kidney injury 2016

Acute kidney injury (AKI) is a syndrome which has a broad range of etiologic factors depending on different clinical settings. Because AKI has significant impacts on prognosis in any clinical settings, early detection and intervention are necessary to improve the outcomes of AKI patients. This clinical guideline for AKI was developed by a multidisciplinary approach with...

The Japanese clinical practice guideline for acute kidney injury 2016

Acute kidney injury (AKI) is a syndrome which has a broad range of etiologic factors depending on different clinical settings. Because AKI has significant impacts on prognosis in any clinical settings, early detection and intervention is necessary to improve the outcomes of AKI patients. This clinical guideline for AKI was developed by a multidisciplinary approach with nephrology...

The Relevance of the Renin-Angiotensin System in the Development of Drugs to Combat Preeclampsia

Preeclampsia is a hypertensive disorder that occurs during pregnancy. It has an unknown etiology and affects approximately 5–8% of pregnancies worldwide. The pathophysiology of preeclampsia is not yet known, and preeclampsia has been called “a disease of theories.” The central symptom of preeclampsia is hypertension. However, the etiology of the hypertension is unknown. In this...

Renal Protective Effects of Resveratrol

18 July 2013; Revised 6 November 2013; Accepted 13 November 2013 Academic Editor: Cristina Angeloni Copyright © 2013 Munehiro Kitada and Daisuke Koya. This is an open access article distributed

Renal Protective Effects of Resveratrol

18 July 2013; Revised 6 November 2013; Accepted 13 November 2013 Academic Editor: Cristina Angeloni Copyright © 2013 Munehiro Kitada and Daisuke Koya. This is an open access article distributed

A very-low-protein diet ameliorates advanced diabetic nephropathy through autophagy induction by suppression of the mTORC1 pathway in Wistar fatty rats, an animal model of type 2 diabetes and obesity

Aims/hypothesisThe efficacy of a low-protein diet (LPD) on diabetic nephropathy is controversial. We aimed to investigate the renoprotective effects of an LPD and the underlying molecular mechanism in a rat model of type 2 diabetes and obesity.MethodsDiabetic male Wistar fatty (fa/fa) rats (WFRs) were treated with a standard diet (23.84% protein) or an LPD (5.77% protein) for 20...

Effect of Antifibrotic MicroRNAs Crosstalk on the Action of N-acetyl-seryl-aspartyl-lysyl-proline in Diabetes-related Kidney Fibrosis

Ishigaki in:Nature Research journals • PubMed • Google ScholarSearch for Keizo Kanasaki in:Nature Research journals • PubMed • Google ScholarSearch for Daisuke Koya in:Nature Research journals • PubMed ... the contract for the consultancy with Boehringer Ingelheim. Corresponding authors Correspondence to Keizo Kanasaki or Daisuke Koya. Supplementary information Word documents1.Supplementary

Animal Models of Diabetes and Its Associated Complications

of diabetes researchers particularly those who are working in the different areas of diabetic complications. Md. Shahidul Islam Daisuke Koya Bernard Portha

Animal Models of Diabetes and Its Associated Complications

of diabetes researchers particularly those who are working in the different areas of diabetic complications. Md. Shahidul Islam Daisuke Koya Bernard Portha

The biological consequence of obesity on the kidney

Obesity is a worldwide epidemic that is associated with several health issues, including kidney diseases. A specific kidney disease, referred to as obesity-related glomerulopathy, has been described in earlier publications. Obesity can affect the prognosis of other types of kidney diseases. Body-weight reduction with caloric restriction is an essential therapy, although strictly...

The Role of Autophagy in the Pathogenesis of Diabetic Nephropathy

paper. Acknowledgment This study was supported by Grants-in-Aid for Scientific Research (KAKENHI) from Japan Society for the Promotion of Science (no. 25713033 to Shinji Kume and no. 25670414 to Daisuke ... Koya). References C. Burton and K. P. G. Harris, “The role of proteinuria in the progression of chronic renal failure,” American Journal of Kidney Diseases, vol. 27, no. 6, pp. 765–775, 1996. View at

The Role of Autophagy in the Pathogenesis of Diabetic Nephropathy

paper. Acknowledgment This study was supported by Grants-in-Aid for Scientific Research (KAKENHI) from Japan Society for the Promotion of Science (no. 25713033 to Shinji Kume and no. 25670414 to Daisuke ... Koya). References C. Burton and K. P. G. Harris, “The role of proteinuria in the progression of chronic renal failure,” American Journal of Kidney Diseases, vol. 27, no. 6, pp. 765–775, 1996. View at

Mammalian autophagy is essential for hepatic and renal ketogenesis during starvation

• PubMed • Google ScholarSearch for Hisazumi Araki in:Nature Research journals • PubMed • Google ScholarSearch for Shin-ichi Araki in:Nature Research journals • PubMed • Google ScholarSearch for Daisuke Koya

Linagliptin-Mediated DPP-4 Inhibition Ameliorates Kidney Fibrosis in Streptozotocin-Induced Diabetic Mice by Inhibiting Endothelial-to-Mesenchymal Transition in a Therapeutic Regimen

Kidney fibrosis is the final common pathway of all progressive chronic kidney diseases, of which diabetic nephropathy is the leading cause. Endothelial-to-mesenchymal transition (EndMT) has emerged as one of the most important origins of matrix-producing fibroblasts. Dipeptidyl peptidase-4 (DPP-4) inhibitors have been introduced into the market as antidiabetes drugs. Here, we...

Comparative Effects of Direct Renin Inhibitor and Angiotensin Receptor Blocker on Albuminuria in Hypertensive Patients with Type 2 Diabetes. A Randomized Controlled Trial

, Shiga, Japan), Masakazu Haneda (Department of Medicine, Asahikawa Medical Univ., Asahikawa, Hokkaido, Japan), Daisuke Koya (epartment of Diabetology and Endocrinology, Kanazawa Medical Univ., Kahoku-gun

Resveratrol Improves Oxidative Stress and Protects Against Diabetic Nephropathy Through Normalization of Mn-SOD Dysfunction in AMPK/SIRT1-Independent Pathway

Munehiro Kitada Shinji Kume Noriko Imaizumi Daisuke Koya OBJECTIVE-Despite the beneficial effects of resveratrol (RSV) on cardiovascular disease and life span, its effects on type 2 diabetic

Dietary Restriction Ameliorates Diabetic Nephropathy through Anti-Inflammatory Effects and Regulation of the Autophagy via Restoration of Sirt1 in Diabetic Wistar Fatty (fa/fa) Rats: A Model of Type 2 Diabetes

Aim. Despite the beneficial effects of dietary restriction (DR) on lifespan, age-related diseases, including diabetes and cardiovascular diseases, its effects on type 2 diabetic nephropathy remain unknown. This study examined the renoprotective effects of DR in Wistar fatty (fa/fa) rats (WFRs). Methods. WFRs were treated with DR (40% restriction) for 24 weeks. Urinary albumin...