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Colon Epithelial MicroRNA Network in Fatty Liver

holding NanoString options. Authors’ Contributions Wendy A. Henderson and Sarah K. Abey designed research. Sarah K. Abey, Natnael D. Kenea, Tatyana G. Vishnyakova, Dan Wang, Nicolaas H. Fourie, and Paule V ... . Joseph performed experiments and collected data. Paule V. Joseph, Sarah K. Abey, Dan Wang, and Tatyana G. Vishnyakova analyzed data. Paule V. Joseph, Dan Wang, Tatyana G. Vishnyakova, Nicolaas H. Fourie

Two draft genome sequences of Pseudomonas jessenii strains isolated from a copper contaminated site in Denmark

Pseudomonas jessenii C2 and Pseudomonas jessenii H16 were isolated from low-Cu and high-Cu industrially contaminated soil, respectively. P. jessenii H16 displayed significant resistance to copper when compared to P. jessenii C2. Here we describe genome sequences and interesting features of these two strains. The genome of P. jessenii C2 comprised 6,420,113 bp, with 5814 protein...

Comparative epidemiology of porcine circovirus type 3 in pigs with different clinical presentations

Porcine circovirus type 3 (PCV3), as an emerging circovirus species, was reported to be widely circulating in the United States, China, South Korea and Poland. Previous studies revealed that PCV3 was mainly concentrated in sick animals with respiratory disease, skin disease, reproductive disorders and so on. However, the circulating status of PCV3 in pigs with other clinical...

Multivariate Time-Varying Copula GARCH Model and Its Application in the Financial Market Risk Measurement

Taking full advantage of the strengths of - distribution, Copula function, and GARCH model in depicting the return distribution of financial asset, we construct the multivariate time-varying - Copula GARCH model which can comprehensively describe “asymmetric, leptokurtic, and heavy-tail” characteristics, the time-varying volatility characteristics, and the extreme-tail dependence...

Multivariate Time-Varying Copula GARCH Model and Its Application in the Financial Market Risk Measurement

Taking full advantage of the strengths of - distribution, Copula function, and GARCH model in depicting the return distribution of financial asset, we construct the multivariate time-varying - Copula GARCH model which can comprehensively describe “asymmetric, leptokurtic, and heavy-tail” characteristics, the time-varying volatility characteristics, and the extreme-tail dependence...

Analysis of secondary structural elements in human microRNA hairpin precursors

Background MicroRNAs (miRNAs) regulate gene expression by targeting complementary mRNAs for destruction or translational repression. Aberrant expression of miRNAs has been associated with various diseases including cancer, thus making them interesting therapeutic targets. The composite of secondary structural elements that comprise miRNAs could aid the design of small molecules...

A Genome-Wide Association Study of Field Resistance to Magnaporthe Oryzae in Rice

Background Breeding of rice cultivars with long-lasting resistance to the rice blast fungus Magnaporthe oryzae is difficult, and identification of new resistance genes is essential. Most of the loci associated with blast resistance against M. oryzae in rice have been identified in controlled environments and with single isolates, and such loci may confer resistance to only a...

Occurrence and sequence analysis of porcine deltacoronaviruses in southern China

wrote the manuscript; Feng Li edited the manuscript; Shao-Lun Zhai and Dan Wang supervised the work. The final version of the manuscript was approved by all authors. Competing interests The authors

Occurrence and sequence analysis of porcine deltacoronaviruses in southern China

the manuscript; Shao-Lun Zhai and Dan Wang supervised the work. The final version of the manuscript was approved by all authors. Competing interests The authors declare that they have no competing

Genome-wide Association Mapping of Cold Tolerance Genes at the Seedling Stage in Rice

Background Rice is a temperature-sensitive crop and its production is severely affected by low temperature in temperate and sub-tropical regions. To understand the genetic basis of cold tolerance in rice, we evaluated the cold tolerance at the seedling stage (CTS) of 295 rice cultivars in the rice diversity panel 1 (RDP1), these cultivars were collected from 82 countries. Results...

Poly (A) Binding Protein Cytoplasmic 1 Is a Novel Co-Regulator of the Androgen Receptor

The androgen receptor (AR) is a member of the steroid receptor superfamily that regulates gene expression in a ligand-dependent manner. The NTD of the AR plays a key role in AR transactivation including androgen-independent activation of the AR in castration-resistant prostate cancer (CRPC) cells. We recently reported that amino acids (a.a.) 50-250 of the NTD are capable of...

Phenethyl isothiocyanate upregulates death receptors 4 and 5 and inhibits proliferation in human cancer stem-like cells

Background The cytokine TRAIL (tumor necrotic factor-related apoptosis-inducing ligand) selectively induces apoptosis in cancer cells, but cancer stem cells (CSCs) that contribute to cancer-recurrence are frequently TRAIL-resistant. Here we examined hitherto unknown effects of the dietary anti-carcinogenic compound phenethyl isothiocyanate (PEITC) on attenuation of proliferation...

Systemic klotho is associated with KLOTHO variation and predicts intrinsic cortical connectivity in healthy human aging

Cognitive decline is a major biomedical challenge as the global population ages. Elevated levels of the longevity factor klotho suppress aging, enhance cognition, and promote synaptic plasticity and neural resilience against aging and Alzheimer’s disease (AD)-related pathogenic proteins. Here, we examined the relationship between human genetic variants of KLOTHO and systemic...

Inhibition of SALL4 reduces tumorigenicity involving epithelial-mesenchymal transition via Wnt/β-catenin pathway in esophageal squamous cell carcinoma

Background Growing evidence suggests that SALL4 plays a vital role in tumor progression and metastasis. However, the molecular mechanism of SALL4 promoting esophageal squamous cell carcinoma (ESCC) remains to be elucidated. Methods The gene and protein expression profiles- were examined by using quantitative real-time PCR, immunohistochemistry and western blotting. Small hairpin...

Molecular Evolution and Genetic Analysis of the Major Capsid Protein VP1 of Duck Hepatitis A Viruses: Implications for Antigenic Stability

The duck hepatitis A virus (DHAV), a member of the family Picornaviridae, is the major cause of outbreaks with high mortality rates in young ducklings. It has three distinctive serotypes and among them, serotypes 1 (DHAV-1) and 3 (DHAV-3) were recognized in China. To investigate evolutionary and antigenic properties of the major capsid protein VP1 of these two serotypes, a...

Influenza-associated outpatient visits among children less than 5 years of age in eastern China, 2011–2014

Background The disease burden of influenza in China has not been well described, especially among young children. The aim of this study was to estimate the incidence of outpatient visits associated with influenza in young children in Suzhou, a city of more than 11 million residents in Jiangsu Province in eastern China. Methods Influenza-like illness (ILI) was defined as the...

Phytochemicals Attenuating Aberrant Activation of β-Catenin in Cancer Cells

Phytochemicals are a rich source of chemoprevention agents but their effects on modulating the Wnt/β-catenin signaling pathway have remained largely uninvestigated. Aberrantly activated Wnt signaling can result in the abnormal stabilization of β-catenin, a key causative step in a broad spectrum of cancers. Here we report the modulation of lithium chloride-activated canonical Wnt...

VPA: an R tool for analyzing sequencing variants with user-specified frequency pattern

Background The massive amounts of genetic variant generated by the next generation sequencing systems demand the development of effective computational tools for variant prioritization. Findings VPA (Variant Pattern Analyzer) is an R tool for prioritizing variants with specified frequency pattern from multiple study subjects in next-generation sequencing study. The tool starts...

Drosophila cyfip Regulates Synaptic Development and Endocytosis by Suppressing Filamentous Actin Assembly

The formation of synapses and the proper construction of neural circuits depend on signaling pathways that regulate cytoskeletal structure and dynamics. After the mutual recognition of a growing axon and its target, multiple signaling pathways are activated that regulate cytoskeletal dynamics to determine the morphology and strength of the connection. By analyzing Drosophila...