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57 papers found.
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Golgin-160 and GMAP210 play an important role in U251 cells migration and invasion initiated by GDNF

Foundation of China (grant Nos. 81372698, 81402918) and Jiangsu University Natural Science Foundation funded project (17KJB310015. Dan Wang: Funding, Lin-Yan Huang: Funding, Introduction Glioma is a ... analysis: Lin Zhang. Funding acquisition: Dan Wang, Lin-Yan Huang, Dian-Shuai Gao. Investigation: Lan Luan, Yue Wang. Methodology: Lan Luan, Yue Wang. 16 / 18 Project administration: Chuan-Xi Tang, Jie

TFDP3 regulates the apoptosis and autophagy in breast cancer cell line MDA-MB-231

Contributions Conceptualization: Ling-yu Ding. Data curation: Ling-yu Ding, Yun-shen Jiao. Formal analysis: Ling-yu Ding. Funding acquisition: Yue-dan Wang. Investigation: Ling-yu Ding. Methodology: Ling-yu ... Ding, Qi Hao. Software: Ling-yu Ding, Yun-shen Jiao. Supervision: Qi Guo, Yue-dan Wang. Validation: Ling-yu Ding, Huan-huan Li. Visualization: Ling-yu Ding, Huan-huan Li. Writing ? original draft

Analysis of dual energy spectral CT and pathological grading of clear cell renal cell carcinoma (ccRCC)

, Jianhong Zhao, Xueling Zhang, Dan Wang, Zhiping Wang, Junlin Zhou. Data curation: Jinyan Wei, Jianhong Zhao, Xueling Zhang, Dan Wang, Wenjuan Zhang, Junlin Zhou. Formal analysis: Jinyan Wei, Jianhong Zhao ... , Jianhong Zhao, Xueling Zhang, Dan Wang, Wenjuan Zhang, Zhiping Wang, Junlin Zhou. Project administration: Jinyan Wei, Junlin Zhou. Resources: Jinyan Wei, Jianhong Zhao, Xueling Zhang, Dan Wang, Wenjuan

The association between vacA or cagA status and eradication outcome of Helicobacter pylori infection: A meta-analysis

involving vacA or cagA; and studies published neither in English nor Chinese; no data of eradication cases to vacA or cagA status. Data extraction Two authors (Dan Wang and Qiuping Li) extracted the data

An androgen reduced transcript of LncRNA GAS5 promoted prostate cancer proliferation

Contributions Conceptualization: Yingyi Zhang, Xinya Su, Xuechao Wan, Yao Li. Data curation: Yingyi Zhang, Xinya Su, Dan Wang. 10 / 12 Formal analysis: Yingyi Zhang, Xinya Su. Investigation: Yingyi Zhang

Effect of age on the diagnostic efficiency of HbA1c for diabetes in a Chinese middle-aged and elderly population: The Shanghai Changfeng Study

curation: Huandong Lin. Formal analysis: Li Wu, Jian Gao. Funding acquisition: Xin Gao. Investigation: Li Wu, Xiaoming Li, Mingfeng Xia, Dan Wang, Qiqige Aleteng, Hui Ma. Methodology: Li Wu, Mingfeng Xia

LncRNA-AF113014 promotes the expression of Egr2 by interaction with miR-20a to inhibit proliferation of hepatocellular carcinoma cells

Long non-coding RNAs (lncRNAs), tentatively identified as non-protein coding RNA, are transcripts more than 200nt in length and accounting for 98% of the whole genome of human being. Accumulating evidence showed aberrant expressions of lncRNAs are strongly correlated to the development of cancers. In this study, AF113014 is a new lncRNA identified from Microarray. We found...

Clinical and neuroimaging characteristics of Chinese dementia with Lewy bodies

Dementia with Lewy bodies (DLB) is the second most common subtype of degenerative dementia. To our knowledge, available information about the clinical features of DLB in China remains limited. Our study therefore aimed to address this issue. Thirty-seven Chinese patients with probable DLB were recruited for this study. All subjects underwent neuropsychological assessment by...

Vitamin D Levels Are Inversely Associated with Liver Fat Content and Risk of Non-Alcoholic Fatty Liver Disease in a Chinese Middle-Aged and Elderly Population: The Shanghai Changfeng Study

Background/Objectives Vitamin D exerts metabolic activities. We investigated whether the 25-hydroxy vitamin D [25(OH)D] is associated with liver fat content (LFC) and non-alcoholic fatty liver disease (NAFLD) in a middle-aged, elderly Chinese population. Subject/Methods A total of 2,960 participants (954 men and 2,006 women) aged over 45 years old were enrolled. Each participant...

A preclinical evaluation of alternative site for islet allotransplantation

The bone marrow cavity (BMC) has recently been identified as an alternative site to the liver for islet transplantation. This study aimed to compare the BMC with the liver as an islet allotransplantation site in diabetic monkeys. Diabetes was induced in Rhesus monkeys using streptozocin, and the monkeys were then divided into the following three groups: Group1 (islets...

Poly (A) Binding Protein Cytoplasmic 1 Is a Novel Co-Regulator of the Androgen Receptor

The androgen receptor (AR) is a member of the steroid receptor superfamily that regulates gene expression in a ligand-dependent manner. The NTD of the AR plays a key role in AR transactivation including androgen-independent activation of the AR in castration-resistant prostate cancer (CRPC) cells. We recently reported that amino acids (a.a.) 50-250 of the NTD are capable of...

Differences in SOM Decomposition and Temperature Sensitivity among Soil Aggregate Size Classes in a Temperate Grasslands

The principle of enzyme kinetics suggests that the temperature sensitivity (Q10) of soil organic matter (SOM) decomposition is inversely related to organic carbon (C) quality, i.e., the C quality-temperature (CQT) hypothesis. We tested this hypothesis by performing laboratory incubation experiments with bulk soil, macroaggregates (MA, 250–2000 μm), microaggregates (MI, 53–250 μm...

miR-4443 Participates in the Malignancy of Breast Cancer

Purpose Chemo-resistance is the leading cause of failure in cancer therapy, however, much remains to be understood about the intrinsic mechanisms. In the present study, we discovered the novel miR-4443 that regulated malignancy of breast cancer both in vitro and in vivo. Methods We examined the expression of miR-4443 in MDA-MB-231/S and MDA-MB-231 Epirubicin-resistant cell lines...

TaLHY, a 1R-MYB Transcription Factor, Plays an Important Role in Disease Resistance against Stripe Rust Fungus and Ear Heading in Wheat

LHY (late elongated hypocotyl) is an important gene that regulates and controls biological rhythms in plants. Additionally, LHY is highly expressed in the SSH (suppression subtractive hybridization) cDNA library-induced stripe rust pathogen (CYR32) in our previous research. To identify the function of the LHY gene in disease resistance against stripe rust, we used RACE-PCR...

Liver Lobe Based Multi-Echo Gradient Recalled Echo T2*-Weighted Imaging in Chronic Hepatitis B-Related Cirrhosis: Association with the Presence and Child-Pugh Class of Cirrhosis

Purpose To investigate whether liver lobe based T2* values measured on gradient recalled echo T2*-weighted imaging are associated with the presence and Child-Pugh class of hepatitis B-related cirrhosis. Methods Fifty-six patients with hepatitis B-related cirrhosis and 23 healthy control individuals were enrolled in this study and underwent upper abdominal T2*-weighted magnetic...

Liver Fat Content Is Associated with Elevated Serum Uric Acid in the Chinese Middle-Aged and Elderly Populations: Shanghai Changfeng Study

Background and Aims Although many studies have indicated a relationship between nonalcoholic fatty liver disease (NAFLD) and hyperuricemia, a few studies specifically examining the effects of the severity of liver fat content (LFC) on serum uric acid (SUA) and the presence of hyperuricemia because of the limitation of the examination methods for NAFLD. In this study, we...

Molecular Evolution and Genetic Analysis of the Major Capsid Protein VP1 of Duck Hepatitis A Viruses: Implications for Antigenic Stability

The duck hepatitis A virus (DHAV), a member of the family Picornaviridae, is the major cause of outbreaks with high mortality rates in young ducklings. It has three distinctive serotypes and among them, serotypes 1 (DHAV-1) and 3 (DHAV-3) were recognized in China. To investigate evolutionary and antigenic properties of the major capsid protein VP1 of these two serotypes, a...

The Inhibitory Effects of Npas4 on Seizures in Pilocarpine-Induced Epileptic Rats

To explore the effects of neuronal Per-Arnt-Sim domain protein 4 (Npas4) on seizures in pilocarpine-induced epileptic rats, Npas4 expression was detected by double-label immunofluorescence, immunohistochemistry, and Western blotting in the brains of pilocarpine-induced epileptic model rats at 6 h, 24 h, 72 h, 7 d, 14 d, 30 d, and 60 d after status epilepticus. Npas4 was localized...

Phytochemicals Attenuating Aberrant Activation of β-Catenin in Cancer Cells

Phytochemicals are a rich source of chemoprevention agents but their effects on modulating the Wnt/β-catenin signaling pathway have remained largely uninvestigated. Aberrantly activated Wnt signaling can result in the abnormal stabilization of β-catenin, a key causative step in a broad spectrum of cancers. Here we report the modulation of lithium chloride-activated canonical Wnt...

A Pilot Study on Clinical and Neuroimaging Characteristics of Chinese Posterior Cortical Atrophy: Comparison with Typical Alzheimer’s Disease

Posterior cortical atrophy (PCA) is a clinicoradiologic neurodegenerative syndrome characterized by predominant impairment of higher visual functions. Neuroimaging and neuropathological studies show that PCA is probably an atypical presentation of Alzheimer’s disease. However, in China PCA has rarely been studied and remains largely unknown. Our study therefore aimed to analyze...