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Fault Diagnosis for Reducer via Improved LMD and SVM-RFE-MRMR

The vibration signals are usually characterized by nonstationary, nonlinearity, and high frequency shocks, and the redundant features degrade the performance of fault diagnosis methods. To deal with the problem, a novel fault diagnosis approach for rotating machinery is presented by combining improved local mean decomposition (LMD) with support vector machine–recursive feature...

Merging perspectives: genotype-directed molecular therapy for hereditary diffuse gastric cancer (HDGC) and E-cadherin–EGFR crosstalk

Hereditary diffuse gastric cancer is a cancer predisposition syndrome associated with germline mutations of the E-cadherin gene (CDH1; NM_004360). Male CDH1 germline mutation carriers have by the age of 80 years an estimated 70% cumulative incidence of gastric cancer, females of 56% for gastric and of 42% for lobular breast cancer. Metastatic HDGC has a poor prognosis which is...

Optimal Urban Logistics Facility Location with Consideration of Truck-Related Greenhouse Gas Emissions: A Case Study of Shenzhen City

The logistics facility location is always involved with great deals of investment. Its construction and operation also bring out a huge amount of the greenhouse gas (GHG) emission due to the consumption of building materials, energy, the running of trucks, and other logistics equipment. Particularly, trucking activities in the urban logistics networks (ULN) are a major source of...

Assessment of factors affecting diabetes management in the City Changing Diabetes (CCD) study in Tianjin

Chen, Xiyue Jing, Xiaoqian Liu, Anna-Mari Volkmann, Dandan Li, Yanan Dong, David Napier. Supervision: Yuanyuan Liu. Writing ? original draft: Jiageng Chen, Xiyue Jing, Xiaoqian Liu. 12 / 13 general

High-throughput SSR marker development and its application in a centipedegrass (Eremochloa ophiuroides (Munro) Hack.) genetic diversity analysis

: Yi Wang, Jingbo Chen, Dandan Li. Writing ? original draft: Jianjian Li. Writing ? review & editing: Jianjian Li, Hailin Guo, Jianxiu Liu. 17 / 20 18 / 20 21. Wang P, Yang L, Zhang E, Qin Z, Wang H

Troxerutin and Cerebroprotein Hydrolysate Injection Protects Neurovascular Units from Oxygen-Glucose Deprivation and Reoxygenation-Induced Injury In Vitro

Li,1 Weiwei Zhang,1 and Yonghua Huang1 1Department of Neurology, PLA Army General Hospital, 5 Nanmencang Dongsishitiao Street, Beijing 100007, China 2Department of Neurology, No. 261 Hospital of PLA

Troxerutin and Cerebroprotein Hydrolysate Injection Protects Neurovascular Units from Oxygen-Glucose Deprivation and Reoxygenation-Induced Injury In Vitro

Li,1 Weiwei Zhang,1 and Yonghua Huang1 1Department of Neurology, PLA Army General Hospital, 5 Nanmencang Dongsishitiao Street, Beijing 100007, China 2Department of Neurology, No. 261 Hospital of PLA

Troxerutin and Cerebroprotein Hydrolysate Injection Protects Neurovascular Units from Oxygen-Glucose Deprivation and Reoxygenation-Induced Injury In Vitro

Li,1 Weiwei Zhang,1 and Yonghua Huang1 1Department of Neurology, PLA Army General Hospital, 5 Nanmencang Dongsishitiao Street, Beijing 100007, China 2Department of Neurology, No. 261 Hospital of PLA

Plants regulate the effects of experimental warming on the soil microbial community in an alpine scrub ecosystem

Qing Liu), the National Natural Science Foundation of China (31570476 to Qing Liu; 31400424 to Dandan Li), and the National Science and Technology Basic Work Project (2015FY110300) to Qing Liu. The ... Zhao, Qing Liu. Data curation: Zhiliang Ma, Mei Liu. Formal analysis: Zhiliang Ma, Chunzhang Zhao, Mei Liu. Funding acquisition: Dandan Li, Qing Liu. Investigation: Zhiliang Ma, Dong Wang, Mei Liu

A Novel Intensive Distribution Logistics Network Design and Profit Allocation Problem considering Sharing Economy

The rapid growth of logistics distribution highlights the problems including the imperfect infrastructure of logistics distribution network, the serious shortage of distribution capacity of each individual enterprise, and the high cost of distribution in China. While the development of sharing economy makes it possible to achieve the integration of whole social logistic resources...

Development and characterization of a polarized human endometrial cell epithelia in an air–liquid interface state

Dandan Li, Hui Li and Ying Wang contributed equally to this work. Electronic supplementary material The online version of this article ( https://doi.org/10.1186/s13287-018-0962-6) contains supplementary

Novel ADAM-17 inhibitor ZLDI-8 enhances the in vitro and in vivo chemotherapeutic effects of Sorafenib on hepatocellular carcinoma cells

Hepatocellular carcinoma (HCC) is one of the greatest life threats for Chinese people, and the prognosis of this malignancy is poor due to the strong chemotherapy resistance in patients. Notch pathway components mediate cell survival and epithelial–mesenchymal transition (EMT), and also participate in the induction of multi-drug resistance (MDR). In the present study, we...

Dual-layer aligned-random nanofibrous scaffolds for improving gradient microstructure of tendon-to-bone healing in a rabbit extra-articular model

Dual-layer aligned-random nanofibrous scaffolds for improving gradient microstructure of tendon-to-bone healing in a rabbit extra-articular model Jiangyu Cai,1,* Juan Wang,2,* Kaiqiang Ye,2 Dandan Li

Progressive and Prognosis Value of Notch Receptors and Ligands in Hepatocellular Carcinoma: A Systematic Review and Meta-analysis

Hepatocellular carcinoma (HCC) is not sensitive to radiotherapy and chemotherapy and experiences postoperative relapse extremely easy, which is the major cause of the high mortality rate. The Notch signaling pathway is expected to become a new target for the biological treatment of HCC. We searched databases for studies that evaluated the expression of Notch receptors and/or...

Responses of nutrient capture and fine root morphology of subalpine coniferous tree Picea asperata to nutrient heterogeneity and competition

manuscript and putting up comments. Author Contributions Conceptualization: Dandan Li, Hongwei Nan, Qing Liu. Data curation: Dandan Li, HuaJun Yin, ChunYing Yin. Formal analysis: Dandan Li, ChunZhang Zhao ... . Funding acquisition: Dandan Li. Investigation: Dandan Li, Jin Liang. Methodology: Dandan Li, ChunZhang Zhao. Project administration: Dandan Li, Hongwei Nan. Resources: Dandan Li, Hongwei Nan. Software

Pharmacokinetic evaluation of the PNC disassembler metarrestin in wild-type and Pdx1-Cre;LSL-KrasG12D/+;Tp53R172H/+ (KPC) mice, a genetically engineered model of pancreatic cancer

PurposeMetarrestin is a first-in-class small molecule clinical candidate capable of disrupting the perinucleolar compartment, a subnuclear structure unique to metastatic cancer cells. This study aims to define the pharmacokinetic (PK) profile of metarrestin and the pharmacokinetic/pharmacodynamic relationship of metarrestin-regulated markers.MethodsPK studies included the...

How the initial level of visibility and limited resource affect the evolution of cooperation

This work sheds important light on how the initial level of visibility and limited resource might affect the evolution of the players’ strategies under different network structure. We perform the prisoner’s dilemma game in the lattice network and the scale-free network, the simulation results indicate that the average density of death in lattice network decreases with the...

Aminoalcohol-Induced Activation of Organophosphorus Hydrolase (OPH) towards Diisopropylfluorophosphate (DFP)

Aminoalcohols have been addressed as activating buffers for alkaline phosphatase. However, there is no record on the buffer activation regarding organophosphorus hydrolase (OPH). Here we reported the activating effects of aminoalcohols on OPH-catalyzed hydrolysis of diisopropylfluorophosphate (DFP), an analog molecule of G-type warfare agents. The kinetic parametors kcat, Vmax...

A combination of NMDA and AMPA receptor antagonists retards granule cell dispersion and epileptogenesis in a model of acquired epilepsy

Rebecca Klee Inken Waltl Kerstin R?mermann Sonja Br?er Sebastian Meller Ingo Gerhauser Vladan Rankovic Dandan Li Claudia Brandt Marion Bankstahl Kathrin T?llner Wolfgang L?scher OPEN Epilepsy may arise ... , Marie Johne, Carolin Hecker, Doris M?ller, Michael Wei?ing, Petra Gr?nig, Claudia Herrmann, Kerstin Rohn, and Caroline Sch?tz for excellent technical assistance. Dandan Li was supported by a grant from