What were the conditions on early Earth when nucleotides were formed, and what are the most plausible nucleoside candidates? Answering these questions will require mechanistic chemistry and planetary science to work together, enhancing not limiting each other’s scope of investigation.
]. In the former case, KIEs are Chiara Colletto and Daniel Whitaker have contributed equally to this work. * Igor Larrosa determined as the ratio of the reaction rate constants (kH/kD) determined by