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Lipidomic profiling of extracellular vesicles derived from prostate and prostate cancer cell lines

Extracellular vesicles (EVs) are produced and secreted from most cells of the body and can be recovered in biological fluids. Although there has been extensive characterisation of the protein and nucleic acid component of EVs, their lipidome has received little attention and may represent a unique and untapped source of biomarkers for prostate cancer diagnosis and prognosis. EVs...

Extracellular vesicles with altered tetraspanin CD9 and CD151 levels confer increased prostate cell motility and invasion

To facilitate intercellular communication, cells release nano-sized, extracellular vesicles (EVs) to transfer biological cargo to both local and distant sites. EVs are enriched in tetraspanins, two of which (CD9 and CD151) have altered expression patterns in many solid tumours, including prostate cancer, as they advance toward metastasis. We aimed to determine whether EVs from...

Animal models of pancreatic cancer and their application in clinical research

Animal models of pancreatic cancer and their application in clinical research Judith Weidenhofer,1,2 Emily K Colvin,3 Danielle R Bond,1,2,4 Christopher J Scarlett2,4 1School of Biomedical Sciences