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In Vitro Activities of Ceftobiprole and Doripenem Tested against Frequently Encountered Aerobic and Facultative Gram-Positive and Gram-Negative Bacterial Pathogens Isolated from Patients in Canadian Hospitals in 2007

BACKGROUND: In 2008, ceftobiprole was approved by Health Canada for the treatment of patients with complicated skin and skin structure infections including diabetic foot infections; approval of ceftobiprole by the United States Food and Drug Administration is pending. Doripenem is currently under review by Health Canada and was approved by the United States Food and Drug...

Subinhibitory Antimicrobial Concentrations: A Review of In Vitro and In Vivo Data

Antimicrobial activity is not an ‘all or none’ effect. An increase in the rate and extent of antimicrobial action is usually observed over a wide range of antimicrobial concentrations. Subinhibitory antimicrobial concentrations are well known to produce significant antibacterial effects, and various antimicrobials at subinhibitory concentrations have been reported to inhibit the...

The New Fluoroquinolones: A Critical Review

OBJECTIVE: This paper reviews the literature available on the new fluoroquinolones – clinafloxacin, gatifloxacin, grepafloxacin, levofloxacin, moxifloxacin, sparfloxacin and trovafloxacin – to compare these agents with each other and contrast them with ciprofloxacin, an older fluoroquinolone.

Characterization of Pseudomonas aeruginosa Isolates Obtained from Patients in Canadian Hospitals: Results of the CANWARD 2007 Study

MSc Michael R Mulvey James A Karlowsky Daryl J Hoban George G Zhanel 54A Antimicrobial resistance; Multidrug-resistant; Pseudomonas aeruginosa - INtRoDuCtIoN: Pseudomonas aeruginosa is an important

Low Prevalence of VRE Gastrointestinal Colonization of Hospitalized Patients in Manitoba Tertiary Care and Community Hospitals

OBJECTIVE: To determine the prevalence of vancomycin-resistant enterococci (VRE) bowel colonization in hospitalized patients in Manitoba who had stool specimens collected for Clostridium difficile toxin and/or culture testing.

Low Prevalence of VRE Gastrointestinal Colonization of Hospitalized Patients in Manitoba Tertiary Care and Community Hospitals

OBJECTIVE: To determine the prevalence of vancomycin-resistant enterococci (VRE) bowel colonization in hospitalized patients in Manitoba who had stool specimens collected for Clostridium difficile toxin and/or culture testing.

Subinhibitory Antimicrobial Concentrations: A Review of In Vitro and In Vivo Data

Antimicrobial activity is not an ‘all or none’ effect. An increase in the rate and extent of antimicrobial action is usually observed over a wide range of antimicrobial concentrations. Subinhibitory antimicrobial concentrations are well known to produce significant antibacterial effects, and various antimicrobials at subinhibitory concentrations have been reported to inhibit the...

Subinhibitory Antimicrobial Concentrations: A Review of In Vitro and In Vivo Data

Antimicrobial activity is not an ‘all or none’ effect. An increase in the rate and extent of antimicrobial action is usually observed over a wide range of antimicrobial concentrations. Subinhibitory antimicrobial concentrations are well known to produce significant antibacterial effects, and various antimicrobials at subinhibitory concentrations have been reported to inhibit the...

Mutant Prevention Concentrations of Doripenem and Meropenem Alone and in Combination with Colistin (Polymyxin E), Levofloxacin and Tobramycin in Pseudomonas aeruginosa

Ed Tam Daryl J Hoban James A Karlowsky Doripenem; Meropenem; Mutant prevention; P aeruginosa - BACKGROUND: With a limited number of available antimicrobial agents to treat Pseudomonas aeruginosa

Mutant Prevention Concentrations of Doripenem and Meropenem Alone and in Combination with Colistin (Polymyxin E), Levofloxacin and Tobramycin in Pseudomonas aeruginosa

Ed Tam Daryl J Hoban James A Karlowsky Doripenem; Meropenem; Mutant prevention; P aeruginosa - BACKGROUND: With a limited number of available antimicrobial agents to treat Pseudomonas aeruginosa

Antimicrobial-Resistant Streptococcus pneumoniae in Canadian Hospitals: Results from the 2007 CANWARD Study

J Hoban 0 George G Zhanel 0 0 AK Wierzbowski , F Tailor, K Nichol, JA Karlowsky, DJ Hoban , GG Zhanel. Antimicrobial-resistant Streptococcus pneumoniae in Canadian hospitals: Results from the 2007 ... Antimicrobial-resistant Streptococcus pneumoniae in Canadian hospitals: Results from the 2007 CANWARD study Aleksandra K Wierzbowski MSc 0 Franil Tailor 0 Kim Nichol MSc 0 James A Karlowsky 0 Daryl

Mechanisms of Reduced Susceptibility to Ciprofloxacin in Escherichia coli Isolates from Canadian Hospitals

OBJECTIVE: To determine whether plasmid-mediated quinolone resistance (PMQR) determinants play a role in the increasing resistance to fluoroquinolones among Escherichia coli isolates in Canadian hospitals, and to determine the mechanisms of reduced susceptibility to ciprofloxacin in a recent collection of 190 clinical E coli isolates.

Antimicrobial-Resistant Streptococcus pneumoniae in Canadian Hospitals: Results from the 2007 CANWARD Study

J Hoban 0 George G Zhanel 0 0 AK Wierzbowski , F Tailor, K Nichol, JA Karlowsky, DJ Hoban , GG Zhanel. Antimicrobial-resistant Streptococcus pneumoniae in Canadian hospitals: Results from the 2007 ... Antimicrobial-resistant Streptococcus pneumoniae in Canadian hospitals: Results from the 2007 CANWARD study Aleksandra K Wierzbowski MSc 0 Franil Tailor 0 Kim Nichol MSc 0 James A Karlowsky 0 Daryl

Prevalence and Characterization of Extended-Spectrum Beta-Lactamase-Producing Enterobacteriaceae Isolated in Canadian Hospitals: Results from CANWARD 2007

OBJECTIVE: The purpose of the present study was to determine the prevalence and molecular epidemiology of extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae identified from Canadian hospitals in 2007. METHODS: Clinically significant isolates were collected as part of the Canadian Ward Surveillance Study (CANWARD 2007) from January to December 2007, inclusive...

The New Fluoroquinolones: A Critical Review

OBJECTIVE: This paper reviews the literature available on the new fluoroquinolones – clinafloxacin, gatifloxacin, grepafloxacin, levofloxacin, moxifloxacin, sparfloxacin and trovafloxacin – to compare these agents with each other and contrast them with ciprofloxacin, an older fluoroquinolone.