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Penetration and efficacy of transdermal NSAIDs in a model of acute joint inflammation

Penetration and efficacy of transdermal NSAIDs in a model of acute joint inflammation David Charles Baranowski,1 Beth Buchanan,1 Heather C Dwyer,1 Joseph P Gabriele,1 Stephanie Kelly,2 Joseph A

A reliable and validated LC-MS/MS method for the simultaneous quantification of 4 cannabinoids in 40 consumer products

. Cannabinoid content in consumer products. CBD, THC, CBDA, THCA content (μg/g) (mean+/- SEM, n = 3). (PDF) Author Contributions Conceptualization: Qingfang Meng, Beth Buchanan, Joseph Gabriele, David Charles ... Buchanan, Joseph Gabriele, David Charles Baranowski. Investigation: Qingfang Meng, Beth Buchanan. Methodology: Qingfang Meng, Beth Buchanan, David Charles Baranowski. 13 / 16 Project administration

The Impact of Vanderbilt Teleneurology: A case report.

This report details the economic impact of Vanderbilt University Medical Center’s Teleneurology service from the perspective of a patient who was treated for an acute stroke at a community-based hospital. This patient’s treatment was successfully managed at the local hospital. The patient and his support system thereby avoided the burden of transfer to a stroke center at a...

Comparative pharmacokinetics and safety assessment of transdermal berberine and dihydroberberine

acid after oral administration of 12 mg/kg simvastatin. Each Value Represents Mean +/- SEM. Statistical analysis was completed using one-way ANOVA, without detection of significance. David Charles ... Baranowski. David Charles Baranowski. Author Contributions Conceptualization: Beth Buchanan, Joseph Gabriele, David Charles Baranowski. Data curation: Beth Buchanan, Qingfang Meng, Mathieu-Marc Poulin

INTEREST IN CD2, a global patient-centred study of long-term cervical dystonia treatment with botulinum toxin

BackgroundLongitudinal cohort studies provide important information about the clinical effectiveness of an intervention in the routine clinical setting, and are an opportunity to understand how a population presents for treatment and is managed.MethodsINTEREST IN CD2 (NCT01753349) is a prospective, international, 3-year, longitudinal, observational study following the course of...

Subthalamic Nucleus Deep Brain Stimulation in Early Stage Parkinson’s Disease Is Not Associated with Increased Body Mass Index

, Amanda D. Currie, and David Charles Department of Neurology, Vanderbilt University Medical Center, 1611 21st Ave S., A-0118 Medical Center North, Nashville, TN 37223-2551, USA Correspondence should be ... addressed to David Charles; ude.tlibrednav@selrahc.divad Received 24 February 2017; Accepted 30 April 2017; Published 6 June 2017 Academic Editor: Raja Mehanna Copyright © 2017 Sarah H. Millan et al. This

Subthalamic Nucleus Deep Brain Stimulation in Early Stage Parkinson’s Disease Is Not Associated with Increased Body Mass Index

, Amanda D. Currie, and David Charles Department of Neurology, Vanderbilt University Medical Center, 1611 21st Ave S., A-0118 Medical Center North, Nashville, TN 37223-2551, USA Correspondence should be ... addressed to David Charles; ude.tlibrednav@selrahc.divad Received 24 February 2017; Accepted 30 April 2017; Published 6 June 2017 Academic Editor: Raja Mehanna Copyright © 2017 Sarah H. Millan et al. This

Teleneurology Consultations for Acute Neurologic Emergencies

for Acute Neurologic Emergencies Authors Parker A. Cunningham, Kelly Harper, Lisa Hermann, Derek A. Riebau, Amber Humphrey, Heather Meyers, and David Charles Teleneurology for Acute Neurologic ... Emergencies By Parker A. Cunningham, Kelly Harper, Lisa Hermann, Derek A. Riebau, Amber Humphrey, Heather Meyers, and David Charles BACKGROUND The U.S. Department of Health and Human Services estimates that

The Relationship between Functional Inhibition and Binding for KCa2 Channel Blockers

Small conductance calcium-activated potassium channels (KCa2.1,2.2,2.3) are blocked with high affinity by both peptide toxins (e.g. apamin) and small molecule blockers (e.g. UCL 1848). In electrophysiological experiments, apamin shows subtype selectivity with IC50s of ∼100 pM and ∼1 nM for block KCa2.2 and KCa2.3 respectively. In binding studies, however, apamin appears not to...

Temporary Resolution of Parkinsonian Tremor Resulting from a Periprocedural Intracranial Hemorrhage

Periprocedural Intracranial Hemorrhage Authors Anna Molinari, Amanda Currie, Maxim Turchan, Walter Sidwell, Chris Kao MD, Derek A. Riebau MD, and David Charles MD This article is available in Tennessee Medicine E ... : David Charles, MD (Phone) 615-936-2025 ((Email) Case Description A 55-year-old right-handed male with a five-year history of idiopathic PD presented to the movement disorders clinic complaining of

Temporary Resolution of Parkinsonian Tremor Resulting from a Periprocedural Intracranial Hemorrhage

Periprocedural Intracranial Hemorrhage Authors Anna Molinari, Amanda Currie, Maxim Turchan, Walter Sidwell, Chris Kao MD, Derek A. Riebau MD, and David Charles MD This article is available in Tennessee Medicine E ... : David Charles, MD (Phone) 615-936-2025 ((Email) Case Description A 55-year-old right-handed male with a five-year history of idiopathic PD presented to the movement disorders clinic complaining of

Cervical dystonia and pain: characteristics and treatment patterns from CD PROBE (Cervical Dystonia Patient Registry for Observation of OnabotulinumtoxinA Efficacy)

To compare profiles of subjects with and without cervical dystonia (CD)-associated pain, to evaluate the contribution of pain and the motor component of CD on quality of life, and to compare the initial botulinum toxin treatment paradigm between pain groups, baseline data were used from the CD Patient Registry for Observation of OnabotulinumtoxinA Efficacy (CD PROBE), a...

Role of Calcium in Phosphatidylserine Externalisation in Red Blood Cells from Sickle Cell Patients

Phosphatidylserine exposure occurs in red blood cells (RBCs) from sickle cell disease (SCD) patients and is increased by deoxygenation. The mechanisms responsible remain unclear. RBCs from SCD patients also have elevated cation permeability, and, in particular, a deoxygenation-induced cation conductance which mediates Ca2

Role of Calcium in Phosphatidylserine Externalisation in Red Blood Cells from Sickle Cell Patients

Phosphatidylserine exposure occurs in red blood cells (RBCs) from sickle cell disease (SCD) patients and is increased by deoxygenation. The mechanisms responsible remain unclear. RBCs from SCD patients also have elevated cation permeability, and, in particular, a deoxygenation-induced cation conductance which mediates Ca2

Subthalamic Nucleus Deep Brain Stimulation Impacts Language in Early Parkinson's Disease

Although deep brain stimulation (DBS) of the basal ganglia improves motor outcomes in Parkinson's disease (PD), its effects on cognition, including language, remain unclear. This study examined the impact of subthalamic nucleus (STN) DBS on two fundamental capacities of language, grammatical and lexical functions. These functions were tested with the production of regular and...

Rationale and design of a prospective study: Cervical Dystonia Patient Registry for Observation of OnaBotulinumtoxinA Efficacy (CD PROBE)

Background A registry of patients with cervical dystonia (Cervical Dystonia Patient Registry for Observation of onaBotulinumtoxinA Efficacy [CD PROBE]) was initiated to capture data regarding physician practices and patient outcomes with onabotulinumtoxinA (BOTOX®, Allergan, Inc., Irvine, CA, USA). Methods and baseline demographics from an interim analysis are provided. Methods...

Clustering of dystonia in some pedigrees with autosomal dominant essential tremor suggests the existence of a distinct subtype of essential tremor

Background There is an ongoing debate whether essential tremor (ET) represents a monosymptomatic disorder or other neurologic symptoms are compatible with the diagnosis of ET. Many patients with clinically definite ET develop dystonia. It remains unknown whether tremor associated with dystonia represent a subtype of ET. We hypothesized that ET with dystonia represents a distinct...

Insensitivity of Paediatric HIV-1 Subtype C Viruses to Broadly Neutralising Monoclonal Antibodies Raised against Subtype B

Background A Phase I clinical trial has been proposed that uses neutralising monoclonal antibodies (MAbs) as passive immunoprophylaxis to prevent mother-to-child transmission of HIV-1 in South Africa. To assess the suitability of such an approach, we determined the sensitivity of paediatric HIV-1 subtype C viruses to the broadly neutralising MAbs IgG1b12, 2G12, 2F5, and 4E10...

Trends in First-Line Antiretroviral Therapy in Asia: Results from the TREAT Asia HIV Observational Database

Background Antiretroviral therapy (ART) has evolved rapidly since its beginnings. This analysis describes trends in first-line ART use in Asia and their impact on treatment outcomes. Methods Patients in the TREAT Asia HIV Observational Database receiving first-line ART for ≥6 months were included. Predictors of treatment failure and treatment modification were assessed. Results...