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Search: authors:"David R Mole"

7 papers found.
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Hypoxic regulation of the noncoding genome and NEAT1

Activation of hypoxia pathways is both associated with and contributes to an aggressive phenotype across multiple types of solid cancers. The regulation of gene transcription by hypoxia-inducible factor (HIF) is a key element in this response. HIF directly upregulates the expression of many hundreds of protein-coding genes, which act to both improve oxygen delivery and to reduce...

Destruction of a distal hypoxia response element abolishes trans-activation of the PAG1 gene mediated by HIF-independent chromatin looping

A crucial step in the cellular adaptation to oxygen deficiency is the binding of hypoxia-inducible factors (HIFs) to hypoxia response elements (HREs) of oxygen-regulated genes. Genome-wide HIF-1α/2α/β DNA-binding studies revealed that the majority of HREs reside distant to the promoter regions, but the function of these distal HREs has only been marginally studied in the genomic...

Integrated analysis of microRNA and mRNA expression and association with HIF binding reveals the complexity of microRNA expression regulation under hypoxia

Carme Camps 0 Harpreet K Saini David R Mole Hani Choudhry 0 Martin Reczko 1 Jos Afonso Guerra-Assuno Ya-Min Tian Francesca M Buffa Adrian L Harris Artemis G Hatzigeorgiou 1 Anton J Enright Jiannis

Cell signalling / renal repair

Introduction and Aims: Aberrant calcium signaling has been implicated in many scenarios of kidney disease and glomerular damage. Gain of function mutations in TRPC6 calcium channels can lead to alterations in proper podocyte morphology and the loss of integrity in the glomerular filter leading to proteinura. Additionally, increases in intracellular calcium in the podocyte occur...

Contrasting effects on HIF-1α regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease

The von Hippel-Lindau tumour suppressor gene product (pVHL) associates with the elongin B and C and Cul2 proteins to form a ubiquitin-ligase complex (VCBC). To date, the only VCBC substrates identified are the hypoxia-inducible factor α subunits (HIF-1α and HIF-2α). However, pVHL is thought to have multiple functions and the significance of HIF-1α and HIF-2α regulation for tumour...