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Vonoprazan: MarKed Competition for PPIs?

1 Department of Physiology, DGSOM at UCLA , Los Angeles, CA , USA 2 & David R. Scott 3 VA GLAHS , 11301 Wilshire Blvd., Bldg. 113, Rm. 324, Los Angeles, CA , USA 4 Department of Medicine, DGSOM at

The Book of Jonah: Foreshadowings of Jesus as the Christ

The book of Jonah is a remarkable story perhaps best known for the stubbornness of a prophet, the great fish that swallows and then regurgitates Jonah, the conversion of the whole city of Nineveh, and the rapid growth and death of a gourd. But this small book has a much deeper, more powerful message that has been obscured through the ages: that the Messiah would live and die to...

Clinical Trial Report: Eradication of Helicobacter pylori Reduces the Risk for Subsequent Gastric Cancer

Joseph R. Pisegna Bijal Surti David R. Scott 0 ) Division of Gastroenterology and Hepatology, VA Greater Los Angeles Healthcare System , 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA - The

Access and care issues in urban urgent care clinic patients

Background Although primary care should be the cornerstone of medical practice, inappropriate use of urgent care for non-urgent patients is a growing problem that has significant economic and healthcare consequences. The characteristics of patients who choose the urgent care setting, as well as the reasoning behind their decisions, is not well established. The purpose of this...

Human Papillomavirus Prevalence in Women Who Have and Have Not Undergone Hysterectomies

We compared human papillomavirus (HPV) prevalence in an age‐stratified random sample of women who have undergone a hysterectomy (WH) (n=573) with the HPV prevalence in age‐matched women with intact cervices (women who have not undergone a hysterectomy [WNH]) (n=581) participating in a study at Kaiser Permanente in Portland, Oregon. Testing cervicovaginal lavage fluids for >40 HPV...

The Elevated 10-Year Risk of Cervical Precancer and Cancer in Women With Human Papillomavirus (HPV) Type 16 or 18 and the Possible Utility of Type-Specific HPV Testing in Clinical Practice

Background: Human papillomavirus (HPV) types 16 and 18 cause 60%–70% of cervical cancer worldwide, and other HPV types cause virtually all remaining cases. Pooled HPV testing for 13 oncogenic types, including HPV16 and 18, is currently used in clinical practice for triage of equivocal cytology and, in conjunction with Pap tests, is an option for general screening among women 30...

Baseline Cytology, Human Papillomavirus Testing, and Risk for Cervical Neoplasia: A 10-Year Cohort Analysis

Background: Annual Pap smear screening has been favored over less frequent screening in the United States to minimize the risk of cervical cancer. We evaluated whether simultaneous screening with a Pap test and human papillomavirus (HPV) testing is useful for assessing the risk for cervical intraepithelial neoplasia (CIN) 3 or cervical cancer. Methods: We enrolled 23 702 subjects...

A Prospective Study of High-Grade Cervical Neoplasia Risk Among Human Papillomavirus-Infected Women

Background: In case–control studies, smoking, parity, and oral contraceptive use have been associated with an increased risk of cervical intraepithelial neoplasia grade 3 (CIN3) and cervical cancer among women who are infected with oncogenic human papillomavirus (HPV). However, these potential risk factors have not been adequately studied in prospective studies. Methods: We...

A Prospective Study of Human Papillomavirus (HPV) Type 16 DNA Detection by Polymerase Chain Reaction and Its Association with Acquisition and Persistence of Other HPV Types

Human papillomavirus (HPV)—16 causes about half the cases of cervical cancer worldwide and is the focus of HPV vaccine development efforts. Systematic data are lacking as to whether the prevention of HPV-16 could affect the equilibrium of infection with other HPV types and thus alter the predicted impact of vaccination on the occurrence of cervical neoplasia. Therefore, the...

Detection of Human Papillomavirus DNA in Cytologically Normal Women and Subsequent Cervical Squamous Intraepithelial Lesions

“Notes” following “References.” 2 Kai-Li Liaw , Andrew G. Glass, M. Michele Manos, Catherine E. Greer, David R. Scott, Mark Sherman, Robert D. Burk, Robert J. Kurman, Sholom Wacholder, Brenda B. Rush