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18 papers found.
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Randomized, Open-Label, Crossover Studies Evaluating the Effect of Food and Liquid Formulation on the Pharmacokinetics of the Novel Focal Adhesion Kinase (FAK) Inhibitor BI 853520

study provided by from Boehringer Ingelheim. Linda C. Pronk and David Schnell are employees of Boehringer Ingelheim. Filip Y. F. L. De Vos has been paid for expert testimonial by Bristol-Myers Squibb, and

Phase I Study of BI 853520, an Inhibitor of Focal Adhesion Kinase, in Patients with Advanced or Metastatic Nonhematologic Malignancies

employee of AstraZeneca; David Schnell and Linda C. Pronk are employees of Boehringer Ingelheim; and Monique Jansen was an employee of Boehringer Ingelheim at the time of study conduct and manuscript

Influence of Renal Impairment on the Pharmacokinetics of Afatinib: An Open-Label, Single-Dose Study

Background and Objective Afatinib is an oral irreversible ErbB-Family Blocker indicated for treatment of patients with EGFR mutation positive advanced non-small cell lung cancer. This trial assessed whether renal impairment influences the pharmacokinetics and safety of afatinib. Methods This was an open-label, single-dose study. Pharmacokinetic parameters after afatinib 40 mg...

Clinical Pharmacokinetics and Pharmacodynamics of Afatinib

interactions [ 64 ]. Acknowledgments The authors would like to thank Marion Schmid for technical support. Compliance with Ethical Standards Conflicts of interest Sven Wind, David Schnell, Thomas Ebner

Bedside Doppler ultrasound for the assessment of renal perfusion in the ICU: advantages and limitations of the available techniques

Three Doppler-derived techniques have been proposed to assess renal perfusion at bedside: Doppler-based renal resistive index (RI) which has been extensively but imperfectly studied in assessing renal allograft status and changes in renal perfusion in critically ill patients and for predicting the reversibility of an acute kidney injury (AKI), semi-quantitative evaluation of...

Influence of Renal Impairment on the Pharmacokinetics of Afatinib: An Open-Label, Single-Dose Study

Background and Objective Afatinib is an oral irreversible ErbB-Family Blocker indicated for treatment of patients with EGFR mutation positive advanced non-small cell lung cancer. This trial assessed whether renal impairment influences the pharmacokinetics and safety of afatinib. Methods This was an open-label, single-dose study. Pharmacokinetic parameters after afatinib 40 mg...

A phase I study of afatinib combined with paclitaxel and bevacizumab in patients with advanced solid tumors

, Joo Ern Ang, Deborah Enting, and Rebecca Kristeleit have declared no conflict of interest. Martina Uttenreuther-Fischer, Karine Pemberton, Katy Pelling, and David Schnell report employment from

Non-invasive mechanical ventilation in hematology patients: let's agree on several things first

Acute respiratory failure is a dreaded and life-threatening event that represents the main reason for ICU admission. Respiratory events occur in up to 50% of hematology patients, including one-half of those admitted to the ICU. Mortality from acute respiratory failure in hematology patients depends on the patient's general status, acute respiratory failure etiology, need for...

Pupillary hippus in nonconvulsive status epilepticus

We report the video recording of a patient who experienced pupillary hippus during an episode of nonconvulsive status epilepticus.

Luciferase Reporter Gene Assay on Human, Murine and Rat Histamine H4 Receptor Orthologs: Correlations and Discrepancies between Distal and Proximal Readouts

The investigation of the (patho)physiological role of the histamine H4 receptor (H4R) and its validation as a possible drug target in translational animal models are compromised by distinct species-dependent discrepancies regarding potencies and receptor subtype selectivities of the pharmacological tools. Such differences were extremely pronounced in case of proximal readouts, e...

Pharmacokinetics of afatinib in subjects with mild or moderate hepatic impairment

Purpose Afatinib, an oral irreversible ErbB family blocker, undergoes minimal metabolism by non-enzyme-catalysed adduct formation with proteins or nucleophilic small molecules and is predominantly non-renally excreted via the entero-hepatic system. This trial assessed whether mild or moderate hepatic impairment influences the pharmacokinetics of afatinib. Methods This was an open...

Acute Kidney Injury in Patients with Newly Diagnosed High-Grade Hematological Malignancies: Impact on Remission and Survival

Background Optimal chemotherapy with minimal toxicity is the main determinant of complete remission in patients with newly diagnosed hematological malignancies. Acute organ dysfunctions may impair the patient’s ability to receive optimal chemotherapy. Design and Methods To compare 6-month complete remission rates in patients with and without acute kidney injury (AKI), we...

Clinical Features and Outcomes in Patients With Disseminated Toxoplasmosis Admitted to Intensive Care: A Multicenter Study

Background. Characteristics and outcomes of adult patients with disseminated toxoplasmosis admitted to the intensive care unit (ICU) have rarely been described. Methods. We performed a retrospective study on consecutive adult patients with disseminated toxoplasmosis who were admitted from January 2002 through December 2012 to the ICUs of 14 university-affiliated hospitals in...

Clinical features of H1N1 2009 infection in critically ill immunocompromised patients

Seasonal influenza virus has been described as an emerging and severe pathogen in immunocompromised hosts. Since the beginning of the 2009 influenza A novel H1N1 pandemic, several series have described the clinical course of the disease in various populations. We report the clinical course of H1N1 2009 infection in 10 immunocompromised patients. Half of the patients received long...

Determinants of Recovery from Severe Posterior Reversible Encephalopathy Syndrome

Objective Few outcome data are available about posterior reversible encephalopathy syndrome (PRES). We studied 90-day functional outcomes and their determinants in patients with severe PRES. Design 70 patients with severe PRES admitted to 24 ICUs in 2001–2010 were included in a retrospective cohort study. The main outcome measure was a Glasgow Outcome Scale (GOS) of 5 (good...

Proceedings of Réanimation 2017, the French Intensive Care Society International Congress

of a multicenter cohort study David Schnell 23 Réanimation polyvalente, Groupe Hospitalier Intercommunal Le Raincy‐Montfermeil , Montfermeil , France 24 Anesthésie réanimation et traitement