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Search: authors:"Davin M. Henderson"

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Detection of CWD in cervids by RT-QuIC assay of third eyelids

. Henderson. Data curation: Sarah K. Cooper, Clare E. Hoover, Davin M. Henderson. Formal analysis: Sarah K. Cooper, Clare E. Hoover, Davin M. Henderson. Funding acquisition: Candace K. Mathiason, Edward A ... . Hoover. Investigation: Sarah K. Cooper, Clare E. Hoover. Methodology: Clare E. Hoover, Davin M. Henderson, Nicholas J. Haley. Project administration: Clare E. Hoover. Resources: Nicholas J. Haley

Detection and Quantification of CWD Prions in Fixed Paraffin Embedded Tissues by Real-Time Quaking-Induced Conversion

Traditional diagnostic detection of chronic wasting disease (CWD) relies on immunodetection of misfolded CWD prion protein (PrPCWD) by western blotting, ELISA, or immunohistochemistry (IHC). These techniques require separate sample collections (frozen and fixed) which may result in discrepancies due to variation in prion tissue distribution and assay sensitivities that limit...

Rapid Antemortem Detection of CWD Prions in Deer Saliva

Chronic wasting disease (CWD) is an efficiently transmitted prion disease of cervids, now identified in 22 United States, 2 Canadian provinces and Korea. One hallmark of CWD is the shedding of infectious prions in saliva, as demonstrated by bioassay in deer. It is also clear that the concentration of prions in saliva, blood, urine and feces is much lower than in the nervous...

Internal deletion compromises the stability of dystrophin

Duchenne muscular dystrophy (DMD) is a deadly and common childhood disease caused by mutations that disrupt dystrophin protein expression. Several miniaturized dystrophin/utrophin constructs are utilized for gene therapy, and while these constructs have shown promise in mouse models, the functional integrity of these proteins is not well described. Here, we compare the...

In Vitro Detection of prionemia in TSE-Infected Cervids and Hamsters

Blood-borne transmission of infectious prions during the symptomatic and asymptomatic stages of disease occurs for both human and animal transmissible spongiform encephalopathies (TSEs). The geographical distribution of the cervid TSE, chronic wasting disease (CWD), continues to spread across North America and the prospective number of individuals harboring an asymptomatic...