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Screening differential circular RNA expression profiles reveal that hsa_circ_0128298 is a biomarker in the diagnosis and prognosis of hepatocellular carcinoma

Screening differential circular RNA expression profiles reveal that hsa-circ-0128298 is a biomarker in the diagnosis and prognosis of hepatocellular carcinoma Dawei Chen,1,2,* Chenyue Zhang,3

Total lymphocyte count, neutrophil–lymphocyte ratio, and platelet–lymphocyte ratio as prognostic factors in advanced non–small cell lung cancer with chemoradiotherapy

Total lymphocyte count, neutrophil-lymphocyte ratio, and platelet-lymphocyte ratio as prognostic factors in advanced non–small cell lung cancer with chemoradiotherapy Xinyu Song,1,2,* Dawei Chen,3 ... : Dr Ahmet Emre Eskazan Xinyu Song,1,2,* Dawei Chen,3,* Ma Yuan,4 Haiyong Wang,1 Zhehai Wang1 1Department of Medical Oncology, Shandong Cancer Hospital Affiliated to Shandong University

The Validity and Reliability between Automated Oscillometric Measurement of Ankle-Brachial Index and Standard Measurement by Eco-Doppler in Diabetic Patients with or without Diabetic Foot

 Min Liu,1 Dawei Chen,1 Chun Wang,1 Guanjian Liu,2 and Xingwu Ran1 1Diabetic Foot Care Center, Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu 610041, China

Hepatocellular carcinoma-targeted effect of configurations and groups of glycyrrhetinic acid by evaluation of its derivative-modified liposomes

Hepatocellular carcinoma-targeted effect of configurations and groups of glycyrrhetinic acid by evaluation of its derivative-modified liposomes Yuqi Sun,1,2 Chunmei Dai,1 Meilin Yin,1 Jinghua Lu,1 Haiyang Hu,2 Dawei Chen2 1School of Pharmacy, Jinzhou Medical University, Jinzhou, China; 2School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China Background: There are...

Single peptide ligand-functionalized uniform hollow mesoporous silica nanoparticles achieving dual-targeting drug delivery to tumor cells and angiogenic blood vessel cells

Ming Xu,3 Guannan Guan,1 Wen Hu,3 Ying Liang,2 Xiuli Zhao,1 Mingxi Qiao,1 Dawei Chen,1 Hao Liu2 1School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 2Department of Pharmacy, Bengbu Medical

Anti-EphA10 antibody-conjugated pH-sensitive liposomes for specific intracellular delivery of siRNA

Dawei Chen,1 Yuihui Deng,1 Xiuli Zhao1 1Department of Pharmaceutics, School of Pharmacy, 2Department of Pharmaceutical Chemistry, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University

Decoration of pH-sensitive copolymer micelles with tumor-specific peptide for enhanced cellular uptake of doxorubicin

, Nanjing c hia Tai Tianqing Pharmaceutical group co. ltd , Nanjing 2 Dawei chen Department of Pharmaceutics, school of Pharmacy, shenyang Pharmaceutical University , 103 Wenhua road, shenyang 110016

pH-responsive hybrid nanoparticle with enhanced dissociation characteristic for siRNA delivery

Qiao,1 Dawei Chen,1 Xiuli Zhao1 1Department of pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, PR China; 2Oncology Department, Affiliated Hongqi Hospital of ... comments 3 Editor who approved publication: Dr Linlin Sun Menghao Shi,1 Xiufeng Zhao,2 Jiulong Zhang,1 Shuang Pan,1 Chunrong Yang,3 Ying Wei,1 Haiyang Hu,1 Mingxi Qiao,1 Dawei Chen,1

A novel disulfide bond-mediated cleavable RGD-modified PAMAM nanocomplex containing nuclear localization signal HMGB1 for enhancing gene transfection efficiency

, Ming Zhao, Haiyang Hu, Dawei Chen Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China Background: Polyamidoamine (PAMAM) dendrimers modified by

The Effect of Autologous Platelet-Rich Gel on the Dynamic Changes of the Matrix Metalloproteinase-2 and Tissue Inhibitor of Metalloproteinase-2 Expression in the Diabetic Chronic Refractory Cutaneous Ulcers

Ulcers Lan Li,1 Dawei Chen,1 Chun Wang,1 Guanjian Liu,2 and Xingwu Ran1 1Diabetic Foot Care Center, Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu 610041 ... Dawei Chen contributed equally to this work. The authors thank the Charge Nurse Min Liu (Diabetic Foot Care Center, Department of Endocrinology and Metabolism, West China Hospital, Sichuan University) for

The Effect of Autologous Platelet-Rich Gel on the Dynamic Changes of the Matrix Metalloproteinase-2 and Tissue Inhibitor of Metalloproteinase-2 Expression in the Diabetic Chronic Refractory Cutaneous Ulcers

Ulcers Lan Li,1 Dawei Chen,1 Chun Wang,1 Guanjian Liu,2 and Xingwu Ran1 1Diabetic Foot Care Center, Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu 610041 ... Dawei Chen contributed equally to this work. The authors thank the Charge Nurse Min Liu (Diabetic Foot Care Center, Department of Endocrinology and Metabolism, West China Hospital, Sichuan University) for

The Effect of Autologous Platelet-Rich Gel on the Dynamic Changes of the Matrix Metalloproteinase-2 and Tissue Inhibitor of Metalloproteinase-2 Expression in the Diabetic Chronic Refractory Cutaneous Ulcers

Ulcers Lan Li,1 Dawei Chen,1 Chun Wang,1 Guanjian Liu,2 and Xingwu Ran1 1Diabetic Foot Care Center, Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu 610041 ... Dawei Chen contributed equally to this work. The authors thank the Charge Nurse Min Liu (Diabetic Foot Care Center, Department of Endocrinology and Metabolism, West China Hospital, Sichuan University) for

Integrated coordination scheduling framework of electricity-natural gas systems considering electricity transmission N − 1 contingencies and gas dynamics

This paper discusses a security-constrained integrated coordination scheduling framework for an integrated electricity-natural gas system (IEGS), in which both tight interdependence between electricity and natural gas transmission networks and their distinct dynamic characteristics at different timescales are fully considered. The proposed framework includes two linear...

Sustained response of malignant pericardial effusion to intrapericardial bevacizumab in an advanced lung cancer patient: a case report and literature review

Sustained response of malignant pericardial effusion to intrapericardial bevacizumab in an advanced lung cancer patient: a case report and literature review Dawei Chen,1,2,* Yan Zhang,2,* Fang Shi,2

Multi-Objective Aerodynamic Optimization of the Streamlined Shape of High-Speed Trains Based on the Kriging Model

Minimizing the aerodynamic drag and the lift of the train coach remains a key issue for high-speed trains. With the development of computing technology and computational fluid dynamics (CFD) in the engineering field, CFD has been successfully applied to the design process of high-speed trains. However, developing a new streamlined shape for high-speed trains with excellent...

Novel Single Nucleotide Polymorphisms in Interleukin 6 Affect Tacrolimus Metabolism in Liver Transplant Patients

Background Tacrolimus is the first-line immunosuppressant after organ transplantation. It is mainly metabolized by cytochrome P450, family 3, subfamily A (CYP3A) enzymes, but there are large individual differences in metabolism. Interleukin 6 (IL6) has been shown to cause a pan-suppression of mRNA levels of ten major CYP enzymes in human hepatocyte cultures. IL6 has been shown to...

Inhibitors of Phosphatidylinositol 3′-Kinases Promote Mitotic Cell Death in HeLa Cells

The phosphatidylinositol 3-kinase (PI3K) pathway plays an important role in many biological processes, including cell cycle progression, cell growth, survival, actin rearrangement and migration, and intracellular vesicular transport. However, the involvement of the PI3K pathway in the regulation of mitotic cell death remains unclear. In this study, we treated HeLa cells with the...

Regulation of Asymmetrical Cytokinesis by cAMP during Meiosis I in Mouse Oocytes

Mammalian oocytes undergo an asymmetrical first meiotic division, extruding half of their chromosomes in a small polar body to preserve maternal resources for embryonic development. To divide asymmetrically, mammalian oocytes relocate chromosomes from the center of the cell to the cortex, but little is known about the underlying mechanisms. Here, we show that upon the elevation...

Identification of a Novel Protein Complex Containing ASIC1a and GABAA Receptors and Their Interregulation

Acid-sensing ion channels (ASICs) belong to the family of the epithelial sodium channel/degenerin (ENaC/DEG) and are activated by extracellular protons. They are widely distributed within both the central and peripheral nervous systems. ASICs were modified by the activation of γ-aminobutyric acid receptors (GABAA), a ligand-gated chloride channels, in hippocampal neurons. In...

Calibration Method to Eliminate Zeroth Order Effect in Lateral Shearing Interferometry

In this paper, a calibration method is proposed which eliminates the zeroth order effect in lateral shearing interferometry. An analytical expression of the calibration error function is deduced, and the relationship between the phase-restoration error and calibration error is established. The analytical results show that the phase-restoration error introduced by the calibration...