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The Landscape of the Prion Protein's Structural Response to Mutation Revealed by Principal Component Analysis of Multiple NMR Ensembles

Prion Proteins (PrP) are among a small number of proteins for which large numbers of NMR ensembles have been resolved for sequence mutants and diverse species. Here, we perform a comprehensive principle components analysis (PCA) on the tertiary structures of PrP globular proteins to discern PrP subdomains that exhibit conformational change in response to point mutations and clade...

Origins and Evolution of the HET-s Prion-Forming Protein: Searching for Other Amyloid-Forming Solenoids

The HET-s prion-forming domain from the filamentous fungus Podospora anserina is gaining considerable interest since it yielded the first well-defined atomic structure of a functional amyloid fibril. This structure has been identified as a left-handed beta solenoid with a triangular hydrophobic core. To delineate the origins of the HET-s prion-forming protein and to discover...

The First Small-Molecule Inhibitors of Members of the Ribonuclease E Family

, University of Leeds, Leeds, LS2 9JT, UKLouise Kime, Deena M. A. Gendoo, Stefanie S. Jourdan, Colin W. G. Fishwick & Kenneth J. McDowallSchool of Biological Sciences and Institute of Biomedical and Biomolecular ... Kime in:Nature Research journals • PubMed • Google ScholarSearch for Helen A. Vincent in:Nature Research journals • PubMed • Google ScholarSearch for Deena M. A. Gendoo in:Nature Research journals

PrionHome: A Database of Prions and Other Sequences Relevant to Prion Phenomena

Prions are units of propagation of an altered state of a protein or proteins; prions can propagate from organism to organism, through cooption of other protein copies. Prions contain no necessary nucleic acids, and are important both as both pathogenic agents, and as a potential force in epigenetic phenomena. The original prions were derived from a misfolded form of the mammalian...