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Total brachial artery reactivity and first time incident coronary heart disease events in a longitudinal cohort study: The multi-ethnic study of atherosclerosis

Ouyang 1 Dhananjay Vaidya 1 0 Ultrasound Reading Center, Department of Radiology, Tufts Medical Center , Boston, MA , United States of America, 2 Department of Medicine, Johns Hopkins University School of ... . Conceptualization: Joseph F. Polak, Pamela Ouyang, Dhananjay Vaidya. Investigation: Joseph F. Polak, Pamela Ouyang, Dhananjay Vaidya. Methodology: Joseph F. Polak, Pamela Ouyang, Dhananjay Vaidya. Project

Estimation of Inorganic Arsenic Exposure in Populations With Frequent Seafood Intake: Evidence From MESA and NHANES

Universitario de Valencia, University of Valencia, Valencia, Spain (Maria Tellez-Plaza); Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland (Dhananjay Vaidya, Eliseo Guallar

Treatment outcomes for patients with Middle Eastern Respiratory Syndrome Coronavirus (MERS CoV) infection at a coronavirus referral center in the Kingdom of Saudi Arabia

Background Middle Eastern Respiratory Syndrome coronavirus (MERS-CoV) is a poorly understood disease with no known treatments. We describe the clinical features and treatment outcomes of patients with laboratory confirmed MERS-CoV at a regional referral center in the Kingdom of Saudi Arabia. Methods In 2014, a retrospective chart review was performed on patients with a laboratory...

PoopMD, a Mobile Health Application, Accurately Identifies Infant Acholic Stools

Biliary atresia (BA) is the leading cause of pediatric end-stage liver disease in the United States. Education of parents in the perinatal period with stool cards depicting acholic and normal stools has been associated with improved time-to-diagnosis and survival in BA. PoopMD is a mobile application that utilizes a smartphone’s camera and color recognition software to analyze an...

The genetic underpinnings of variation in ages at menarche and natural menopause among women from the multi-ethnic Population Architecture using Genomics and Epidemiology (PAGE) Study: A trans-ethnic meta-analysis

Omri Gottesman 4 Noura S. Abul-Husn 4 Erwin P. Bottinger 4 Ruth J. F. Loos 4 Leslie J. Raffel 4 Jie Yao 4 Xiuqing Guo 4 Suzette J. Bielinski 4 Jerome I. Rotter 4 Dhananjay Vaidya 4 Yii-Der Ida Chen 4 ... P. Bottinger, Ruth J. F. Loos, Leslie J. Raffel, Jie Yao, Xiuqing Guo, Suzette J. Bielinski, Dhananjay Vaidya, Yii-Der Ida Chen, Sheila F. Casta?eda, Martha Daviglus, Robert Kaplan, Gregory A

Sex Differences in Diabetes and Risk of Incident Coronary Artery Disease in Healthy Young and Middle-Aged Adults

Dhananjay Vaidya Controversy exists about the coronary artery disease (CAD) risk conveyed by diabetes in young and middle-aged women. We investigated sex differences in CAD by diabetes status among healthy

Independent Metabolic Syndrome Variants Predict New-Onset Coronary Artery Disease

DHANANJAY VAIDYA PHD RASIKA A. MATHIAS PHD BRIAN G. KRAL LISA R. YANEK MS LEWIS C. BECKER DIANE M. BECKER SCD C a r d i o v a s c u l a r a n d OBJECTIVE - Any combination of metabolic abnormalities

Sex-Steroid Hormones and Electrocardiographic QT-Interval Duration: Findings From the Third National Health and Nutrition Examination Survey and the Multi-Ethnic Study of Atherosclerosis

. Post, Darshan Dalal, Dhananjay Vaidya, Gordon F. Tomaselli); Department of Epidemiology and Prevention, School of Medicine, Wake Forest University, Winston Salem, North Carolina (Elsayed Z. Soliman); and

Defining the Metabolic Syndrome Construct: Multi-Ethnic Study of Atherosclerosis (MESA) cross-sectional analysis

DHANANJAY VAIDYA MBBS PHD MOYSES SZKLO DRPH KIANG LIU PHD PAMELA J. SCHREINER PHD ALAIN G. BERTONI PHD PAMELA OUYANG C a r d i o v a s c u l a r a n d OBJECTIVE - It is controversial whether the

Clinical Findings and Pro-Inflammatory Cytokines in Dengue Patients in Western India: A Facility-Based Study

Background Descriptions of dengue immunopathogenesis have largely relied on data from South-east Asia and America, while India is poorly represented. This study characterizes dengue cases from Pune, Western India, with respect to clinical profile and pro-inflammatory cytokines. Methodology/Principal Findings In 2005, 372 clinically suspected dengue cases were tested by MAC-ELISA...

Inflammation and the Incidence of Type 2 Diabetes: The Multi-Ethnic Study of Atherosclerosis (MESA)

ALAIN G. BERTONI GREGORY L. BURKE MSC JAMES A. OWUSU MERCEDES R. CARNETHON PHD DHANANJAY VAIDYA PHD R. GRAHAM BARR DRPH NANCY S. JENNY PHD PAMELA OUYANG MBBS JEROME I. ROTTER E p i d e m i o l o g y

Association of Endogenous Sex Hormones With Diabetes andImpaired Fasting Glucose in Men: Multi-Ethnic Study of Atherosclerosis*

LAURA A. COLANGELO MS PAMELA OUYANG KIANG LIU PHD PETER KOPP SHERITA HILL GOLDEN ADRIAN S. DOBS MHS MOYSES SZKLO DRPH DHANANJAY VAIDYA PHD MARY CUSHMAN SUSAN M. GAPSTUR PHD E p i d e m i o l o g y

Metabolic Syndrome Derived from Principal Component Analysis and Incident Cardiovascular Events: The Multi Ethnic Study of Atherosclerosis (MESA) and Health, Aging, and Body Composition (Health ABC)

) Subhashish Agarwal,1,2 David R. Jacobs Jr.,3 Dhananjay Vaidya,4 Christopher T. Sibley,5 Neal W. Jorgensen,6 Jerome I. Rotter,7 Yii-Der Ida Chen,7 Yongmei Liu,8 Jeanette S. Andrews,9 Stephen Kritchevsky,10 Bret

The impact of FADS genetic variants on ω6 polyunsaturated fatty acid metabolism in African Americans

Background Arachidonic acid (AA) is a long-chain omega-6 polyunsaturated fatty acid (PUFA) synthesized from the precursor dihomo-gamma-linolenic acid (DGLA) that plays a vital role in immunity and inflammation. Variants in the Fatty Acid Desaturase (FADS) family of genes on chromosome 11q have been shown to play a role in PUFA metabolism in populations of European and Asian...

Early Onset Heart Failure in Transgenic Mice with Dilated Cardiomyopathy

In children, dilated cardiomyopathy is due to a variety of etiologies and usually carries a grave prognosis. The purpose of the present study was to carefully follow the progression of events leading to cardiac dilatation and congestive heart failure in a dilated cardiomyopathy model in neonatal and juvenile mice. These initial steps are often not well characterized. Furthermore...

A Bivariate Genome-Wide Approach to Metabolic Syndrome: STAMPEED Consortium

OBJECTIVE The metabolic syndrome (MetS) is defined as concomitant disorders of lipid and glucose metabolism, central obesity, and high blood pressure, with an increased risk of type 2 diabetes and cardiovascular disease. This study tests whether common genetic variants with pleiotropic effects account for some of the correlated architecture among five metabolic phenotypes that...

Meta-Analysis of Genome-Wide Association Studies in African Americans Provides Insights into the Genetic Architecture of Type 2 Diabetes

Type 2 diabetes (T2D) is more prevalent in African Americans than in Europeans. However, little is known about the genetic risk in African Americans despite the recent identification of more than 70 T2D loci primarily by genome-wide association studies (GWAS) in individuals of European ancestry. In order to investigate the genetic architecture of T2D in African Americans, the...

A Genome-Wide Association Meta-Analysis of Circulating Sex Hormone–Binding Globulin Reveals Multiple Loci Implicated in Sex Steroid Hormone Regulation

Sex hormone-binding globulin (SHBG) is a glycoprotein responsible for the transport and biologic availability of sex steroid hormones, primarily testosterone and estradiol. SHBG has been associated with chronic diseases including type 2 diabetes (T2D) and with hormone-sensitive cancers such as breast and prostate cancer. We performed a genome-wide association study (GWAS) meta...

Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility

Fasting glucose and insulin are intermediate traits for type 2 diabetes. Here we explore the role of coding variation on these traits by analysis of variants on the HumanExome BeadChip in 60,564 non-diabetic individuals and in 16,491 T2D cases and 81,877 controls. We identify a novel association of a low-frequency nonsynonymous SNV in GLP1R (A316T; rs10305492; MAF=1.4%) with...