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Transcriptomic and functional network features of lung squamous cell carcinoma through integrative analysis of GEO and TCGA data

The study was supported by Outstanding study plan of Fudan University. Author Contributions Conceived and designed the study: Yin Li, Chunlai Lu and Di Ge. Performed the experiments: Yin Li. Wrote the ... paper: Yin Li, Jie Gu, Fengkai Xu, Qiaoliang Zhu, Chunlai Lu and Di Ge. Analyzed the data: Yin Li and Chunlai Lu. All authors read and approved the final manuscript. 1 1 Publisher?s note: Springer Nature

Finding ATF4/p75NTR/IL-8 Signal Pathway in Endothelial–Mesenchymal Transition by Safrole Oxide

Targeting the endothelial-to-mesenchymal transition (EndoMT) may be a novel therapeutic strategy for cancer and various diseases induced by fibrosis. We aimed to identify a small chemical molecule as an inducer of EndoMT and find a new signal pathway by using the inducer. Safrole oxide (SFO), 50 µg/ml, could most effectively induce EndoMT within 12 h. To understand the underlying...

USP7 overexpression predicts a poor prognosis in lung squamous cell carcinoma and large cell carcinoma

In non-small cell lung cancer (NSCLC), both USP7 expression and p53 gene status were reported to be an indicator of poor prognosis in adenocarcinoma patients; however, its roles and mechanisms in lung squamous cell carcinoma and large cell carcinoma need to be clarified. The USP7 expression was examined in NSCLC tumors (excluding adenocarcinoma), their corresponding non-tumorous...

Diazoxide-Mediated Growth Inhibition in Human Lung Cancer Cells via Downregulation of β-Catenin-Mediated Cyclin D1 Transcription

Treatment of various types of cells with the mitochondrial ATP-sensitive K+ channel opener, diazoxide, preconditions cells to subsequent injuries and inhibits apoptosis. However, the role and mechanism(s) of diazoxide in solid tumor cell growth are largely unknown. Here we demonstrate that diazoxide inhibited the proliferation of lung cancer cells as well as the transcription of...

Human vascular endothelial cells reduce sphingosylphosphorylcholine-induced smooth muscle cell contraction in co-culture system through integrin β4 and Fyn

understanding the mechanism by which VECs control the SPC-induced contraction of VSMCs. Author contribution Jun-ying MIAO, Jing ZHAO, and Yun ZHANG designed the research; Di GE, Ning MENG, Le SU, Shang-li ... ZHANG, and Jing ZHAO performed the research; Shang-li ZHANG analyzed the data; and Jing ZHAO, Di GE, and Ning MENG wrote the paper. References 1. Kalsner S. Coronary artery spasm. Multiple causes and

Establishment and characterization of esophageal squamous cell carcinoma patient-derived xenograft mouse models for preclinical drug discovery

The purpose of this study was to establish and characterize patient-derived esophageal squamous cell carcinoma xenograft (PDECX) mice for utilization in antitumor drug discovery. A total of 96 esophageal squamous cell carcinoma (ESCC) tissues from Chinese patients were transplanted subcutaneously into immunodeficient mice. Histology, EGFR, K-ras, B-raf, and PIK3CA mutations, and...

FoxM1 Is Associated with Poor Prognosis of Non-Small Cell Lung Cancer Patients through Promoting Tumor Metastasis

Background FoxM1 has been reported to be important in initiation and progression of various tumors. However, whether FoxM1 has any indication for prognosis in non-small cell lung cancer patients remains unclear. Methodology/Principal Findings In this study, FoxM1 expression in tumor cells was examined first by immunohistochemistry in 175 NSCLC specimens, the result of which...

Trastuzumab anti-tumor efficacy in patient-derived esophageal squamous cell carcinoma xenograft (PDECX) mouse models

Background Trastuzumab is currently approved for the clinical treatment of breast and gastric cancer patients with HER-2 positive tumors, but not yet for the treatment of esophageal carcinoma patients, whose tumors typically show 5 ~ 35% HER-2 gene amplification and 0 ~ 56% HER-2 protein expression. This study aimed to investigate the therapeutic efficacy of Trastuzumab in...

Tumor Initiating Cells in Esophageal Squamous Cell Carcinomas Express High Levels of CD44

Background Esophageal Squamous Cell Carcinoma (ESCC) is a major subtype of esophageal cancer causing significant morbility and mortality in Asia. Mechanism of initiation and progression of this disease is unclear. Tumor initiating cells (TICs) are the subpopulation of cells which have the ability to self-renew, as well as, to drive initiation and progression of cancer. Increasing...