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22 papers found.
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Selective colony area method for heterogeneous patient-derived tumor cell lines in anti-cancer drug screening system

Woo Lee, Jeeyun Lee. Writing ? original draft: Jang Ho Cho. Writing ? review & editing: Jung Yong Hong, Jeeyun Lee. Supervision: Seung Tae Kim, Joon Oh Park, Young Suk Park, Do-Hyun Nam, Jeeyun Lee

In vivo distribution of U87MG cells injected into the lateral ventricle of rats with spinal cord injury

Foundation (NRF-2016R1A5A2945889, NRF2016R1D1A1B03933833, and NRF-2016R1A6A3A11930396). Author Contributions Conceptualization: Jeong-Seob Won, Hyun Nam, Hye Won Lee, Do-Hyun Nam, Sun-Ho Lee, Kyeung Min Joo ... ± review & editing: Hyun Nam, Hye Won Lee, Do-Hyun Nam, Sun-Ho Lee, Kyeung Min Joo. 12 / 14 13 / 14 1. Holmes D . Spinal-cord injury: spurring regrowth . Nature . 2017 ; 552 ( 7684 ):S49. https://doi.org

WNT signaling in glioblastoma and therapeutic opportunities

ScholarSearch for Sun Hee Ahn in:Nature Research journals • PubMed • Google ScholarSearch for Jeongwu Lee in:Nature Research journals • PubMed • Google ScholarSearch for Do-Hyun Nam in:Nature Research journals ... • PubMed • Google Scholar Competing interests The authors declare no conflict of interest. Corresponding author Correspondence to Do-Hyun Nam. Rights and permissions To obtain permission to re-use

Natural killer (NK) cells inhibit systemic metastasis of glioblastoma cells and have therapeutic effects against glioblastomas in the brain

Background Glioblastoma multiforme (GBM) is characterized by extensive local invasion, which is in contrast with extremely rare systemic metastasis of GBM. Molecular mechanisms inhibiting systemic metastasis of GBM would be a novel therapeutic candidate for GBM in the brain. Methods Patient-derived GBM cells were primarily cultured from surgical samples of GBM patients and were...

TopBP1 and Claspin contribute to the radioresistance of lung cancer brain metastases

Background Radiation therapy is one of the most effective therapeutic tools for brain metastasis. However, it is inevitable that some cancer cells become resistant to radiation. This study is focused on the identification of genes associated with radioresistance in metastatic brain tumor from lung cancer and the functional examination of the selected genes with regards to altered...

Application of single-cell RNA sequencing in optimizing a combinatorial therapeutic strategy in metastatic renal cell carcinoma

Background Intratumoral heterogeneity hampers the success of marker-based anticancer treatment because the targeted therapy may eliminate a specific subpopulation of tumor cells while leaving others unharmed. Accordingly, a rational strategy minimizing survival of the drug-resistant subpopulation is essential to achieve long-term therapeutic efficacy. Results Using single-cell...

Single-cell mRNA sequencing identifies subclonal heterogeneity in anti-cancer drug responses of lung adenocarcinoma cells

Background Intra-tumoral genetic and functional heterogeneity correlates with cancer clinical prognoses. However, the mechanisms by which intra-tumoral heterogeneity impacts therapeutic outcome remain poorly understood. RNA sequencing (RNA-seq) of single tumor cells can provide comprehensive information about gene expression and single-nucleotide variations in individual tumor...

FoxM1 Promotes Stemness and Radio-Resistance of Glioblastoma by Regulating the Master Stem Cell Regulator Sox2

Glioblastoma (GBM) is the most aggressive and most lethal brain tumor. As current standard therapy consisting of surgery and chemo-irradiation provides limited benefit for GBM patients, novel therapeutic options are urgently required. Forkhead box M1 (FoxM1) transcription factor is an oncogenic regulator that promotes the proliferation, survival, and treatment resistance of...

Clonal evolution of glioblastoma under therapy

Lasorella in:Nature Research journals • PubMed • Google ScholarSearch for Do-Hyun Nam in:Nature Research journals • PubMed • Google ScholarSearch for Gaetano Finocchiaro in:Nature Research journals • PubMed ... , and wrote the manuscript. Competing interests The authors declare no competing financial interests. Corresponding authors Correspondence to Do-Hyun Nam or Gaetano Finocchiaro or Antonio Iavarone or Raul

NTRK1 Fusion in Glioblastoma Multiforme

Kyeung Min Joo 0 Do-Hyun Nam 0 James Bradley Elder, The Ohio State University Medical Center, United States of America 0 1 Samsung Biomedical Research Institute, Samsung Medical Center , Seoul , Korea

Two cilengitide regimens in combination with standard treatment for patients with newly diagnosed glioblastoma and unmethylated MGMT gene promoter: results of the open-label, controlled, randomized phase II CORE study

, controlled, randomized phase II CORE study L. Burt Nabors () Karen L. Fink Tom Mikkelsen Danica Grujicic Rafal Tarnawski Do Hyun Nam Maria Mazurkiewicz Michael Salacz 0 Lynn Ashby Vittorina Zagonel Roberta

Wnt/β-catenin signaling is a key downstream mediator of MET signaling in glioblastoma stem cells

Background Glioblastoma (GBM) is the most lethal and common type of primary brain tumor. Recent evidence suggests that a subpopulation of GBM cells (glioblastoma stem cells [GSCs]) is critical for tumor progression, invasion, and therapeutic resistance. We and others have demonstrated that MET, a receptor tyrosine kinase, positively regulates the stemness phenotype and...

Radiosensitization of brain metastasis by targeting c-MET

Radiotherapy is the most widely used therapeutic modality in brain metastasis; however, it only provides palliation due to inevitable tumor recurrence. Resistance of tumor cells to ionizing radiation is a major cause of treatment failure. A critical unmet need in oncology is to develop rationale driven approaches that can enhance the efficacy of radiotherapy against metastatic...

Erratum to: The Neural Stem Cell Fate Determinant TLX Promotes Tumorigenesis and Genesis of Cells Resembling Glioma Stem Cells

Kim Do-Hyun Nam Hyunggee Kim This paper was initially submitted to Journal 'Molecules and Cells' without approval from two coauthors. According to the decision of editorial committee, I, as a

Translational Validation of Personalized Treatment Strategy Based on Genetic Characteristics of Glioblastoma

Glioblastoma (GBM) heterogeneity in the genomic and phenotypic properties has potentiated personalized approach against specific therapeutic targets of each GBM patient. The Cancer Genome Atlas (TCGA) Research Network has been established the comprehensive genomic abnormalities of GBM, which sub-classified GBMs into 4 different molecular subtypes. The molecular subtypes could be...

A practical scoring system to determine whether to proceed with surgical resection in recurrent glioblastoma

Background To determine the benefit of surgical management in recurrent glioblastoma, we analyzed a series of patients with recurrent glioblastoma who had undergone surgery, and we devised a new scale to predict their survival.

Impact of adjuvant chemotherapy for gliomatosis cerebri

Background Gliomatosis cerebri (GC) is characterized by a diffuse infiltration of tumor cells throughout CNS, however, few details are available about the chemotherapeutic effect on GC. The aim of this study was to investigate its clinical course and to determine the efficacy of chemotherapy for GC. Methods Between Jan. 1999 and Dec. 2004, 37 GC patients were diagnosed by biopsy...

Phase II trial of low-dose continuous (metronomic) treatment of temozolomide for recurrent glioblastoma

The prognosis for patients with recurrent glioblastomas (GBMs) is dismal, with a median survival of 3–6 months. We performed a phase II trial of low-dose continuous (metronomic) treatment using temozolomide (TMZ) for recurrent GBMs. TMZ-refractory patients with GBM who experienced disease recurrence or progression during or after the cyclic treatment schedule of TMZ after surgery...

Trans-Differentiation of Neural Stem Cells: A Therapeutic Mechanism Against the Radiation Induced Brain Damage

-Seok Im Dong-Sup Lee Do-Hoon Lim Dong Hyun Kim Hong-Duck Um Sang-Hun Lee Jung-II Lee Do-Hyun Nam Jianghong Rao, Stanford University, United States of America Radiation therapy is an indispensable

Clinical significance of molecular genetic changes in sporadic invasive pituitary adenomas

Several molecular and genetic changes have been found in pituitary adenomas. We looked for correlations between these changes and the degree of invasiveness of the tumors. The invasiveness of 11 pituitary adenomas was graded by Hardy classification. We examined the retinoblastoma gene (RB1.20 on chromosome 13q) and the region around the MEN1 locus (chromosome 11q13.1-5) for loss...