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The Role of Infection in Acute Exacerbation of Idiopathic Pulmonary Fibrosis

Dong Weng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the ... in the writing and/or revision of the article. MK is responsible for the English edition of the manuscript. Dong Weng, Xian-Qiu Chen, Hui Qiu and Yuan Zhang contributed equally to this work

IL-10-Producing B Cells Suppress Effector T Cells Activation and Promote Regulatory T Cells in Crystalline Silica-Induced Inflammatory Response In Vitro

,1 Dong Weng,1,2 and Jie Chen1 1Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, China 2Department of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji

2-aminopurine suppresses the TGF-β1-induced epithelial–mesenchymal transition and attenuates bleomycin-induced pulmonary fibrosis

University School of Medicine, Shanghai, China Dong Weng and Jian-xia Chen have contributed equally to this work. Edited by A. Rufini AffiliationsClinical Translation Research Center, Shanghai Pulmonary ... , Shanghai, ChinaHao-hao Li & Baoxue Ge AuthorsSearch for Dong Weng in:Nature Research journals • PubMed • Google Scholar Search for Jian-xia Chen in:Nature Research journals • PubMed • Google Scholar Search

Role of IL-10-producing regulatory B cells in modulating T-helper cell immune responses during silica-induced lung inflammation and fibrosis

Silicosis is characterized by chronic lung inflammation and fibrosis, which are seriously harmful to human health. Previous research demonstrated that uncontrolled T-helper (Th) cell immune responses were involved in the pathogenesis of silicosis. Lymphocytes also are reported to have important roles. Existing studies on lymphocyte regulation of Th immune responses were limited...

Blockade of Wnt/β-Catenin Pathway Aggravated Silica-Induced Lung Inflammation through Tregs Regulation on Th Immune Responses

Chen, Dong Weng, and Jie Chen Division of Pneumoconiosis, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang 110122, China Received 7 December 2015

Identification of a nanobody specific to human pulmonary surfactant protein A

Medicine, Shanghai, ChinaShan-Mei Wang, Meng-Meng Zhao, Nan Li, Liu-Sheng Wang, Yang Hu, Yu-Kui Du, Shan-Shan Du, Yan Li, Ya-Ru Wei, Dong Weng & Hui-Ping LiShanghai Institute of Applied Physics, Chinese ... in:Nature Research journals • PubMed • Google Scholar Search for Jian-Hua He in:Nature Research journals • PubMed • Google Scholar Search for Dong Weng in:Nature Research journals • PubMed • Google Scholar

Reduction of IL-17A Might Suppress the Th1 Response and Promote the Th2 Response by Boosting the Function of Treg Cells during Silica-Induced Inflammatory Response In Vitro

, Ying Chen, Laiyu Song, Wujing Dai, Chao Li, Dong Weng, and Jie Chen Division of Pneumoconiosis, School of Public Health, China Medical University, No. 92 North 2nd Road, Heping District, Shenyang

Reduction of IL-17A Might Suppress the Th1 Response and Promote the Th2 Response by Boosting the Function of Treg Cells during Silica-Induced Inflammatory Response In Vitro

, Ying Chen, Laiyu Song, Wujing Dai, Chao Li, Dong Weng, and Jie Chen Division of Pneumoconiosis, School of Public Health, China Medical University, No. 92 North 2nd Road, Heping District, Shenyang

Reduction of IL-17A Might Suppress the Th1 Response and Promote the Th2 Response by Boosting the Function of Treg Cells during Silica-Induced Inflammatory Response In Vitro

, Ying Chen, Laiyu Song, Wujing Dai, Chao Li, Dong Weng, and Jie Chen Division of Pneumoconiosis, School of Public Health, China Medical University, No. 92 North 2nd Road, Heping District, Shenyang

Screening for Differentially Expressed Proteins Relevant to the Differential Diagnosis of Sarcoidosis and Tuberculosis

Background In this study, we sought to identify differentially expressed proteins in the serum of patients with sarcoidosis or tuberculosis and to evaluate these proteins as markers for the differential diagnosis of sarcoidosis and sputum-negative tuberculosis. Methods Using protein microarrays, we identified 3 proteins exhibiting differential expression between patients with...

Tregs Promote the Differentiation of Th17 Cells in Silica-Induced Lung Fibrosis in Mice

Background Silicosis is an occupational lung disease caused by inhalation of silica dust and characterized by lung inflammation and fibrosis. Previous study showed that Tregs regulate the process of silicosis by modulating the maintenance of immune homeostasis in the lung. Th17 cells share reciprocal developmental pathway with Tregs and play a pivotal role in the...

Evaluation of Paeonol Skin-Target Delivery from Its Microsponge Formulation: In Vitro Skin Permeation and In Vivo Microdialysis

The aim of the present study was to design a novel topical skin-target drug-delivery system, the paeonol microsponge, and to investigate its drug-release patterns in dosage form, both in vitro and in vivo. Paeonol microsponges were prepared using the quasi-emulsion solvent-diffusion method. In vitro release studies were carried out using Franz diffusion cells, while in vivo...

A novel nanobody specific for respiratory surfactant protein A has potential for lung targeting

Shan-Shan Du,1 Zhao-Fang Yin,1 Ya-Ru Wei,1 Xavier Mulet,5 Greg Coia,6 Dong Weng,1 Jian-Hua He,3 Min Wu,7 Hui-Ping Li1 1Department of Respiratory Medicine, Shanghai Pulmonary Hospital, School of Medicine

CD4+CD25+Foxp3+ Regulatory T Cells Depletion May Attenuate the Development of Silica-Induced Lung Fibrosis in Mice

Background Silicosis is an occupational lung disease caused by inhalation of silica dust characterized by lung inflammation and fibrosis. Previous study showed that Th1 and Th2 cytokines are involved in silicosis, but Th1/Th2 polarization during the development of silicosis is still a matter of debate. Regulatory T cells (Treg cells) represent a crucial role in modulation of...

Identification and classification of high risk groups for Coal Workers' Pneumoconiosis using an artificial neural network based on occupational histories: a retrospective cohort study

Background Coal workers' pneumoconiosis (CWP) is a preventable, but not fully curable occupational lung disease. More and more coal miners are likely to be at risk of developing CWP owing to an increase in coal production and utilization, especially in developing countries. Coal miners with different occupational categories and durations of dust exposure may be at different...

Induction of CCL8/MCP-2 by Mycobacteria through the Activation of TLR2/PI3K/Akt Signaling Pathway

Pleural tuberculosis (TB), together with lymphatic TB, constitutes more than half of all extrapulmonary cases. Pleural effusions (PEs) in TB are representative of lymphocytic PEs which are dominated by T cells. However, the mechanism underlying T lymphocytes homing and accumulation in PEs is still incompletely understood. Here we performed a comparative analysis of cytokine...