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21 papers found.
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Impact of primordial ultracompact minihaloes on the intergalactic medium and first structure formation

The effects of dark matter annihilation on the evolution of the intergalactic medium (IGM) in the early Universe will be more important if the dark matter structure is more concentrated. Ultracompact minihaloes (UCMHs), which formed through dark matter accretion on to primordial black holes (PBHs) or an initial dark matter overdensity produced by a primordial density perturbation...

Radiation pressure-driven galactic winds from self-gravitating discs

We study large-scale winds driven from uniformly bright self-gravitating discs radiating near the Eddington limit. We show that the ratio of the radiation pressure force to the gravitational force increases with height above the disc surface to a maximum of twice the value of the ratio at the disc surface. Thus, uniformly bright self-gravitating discs radiating at the Eddington...

Global identification of the genetic networks and cis-regulatory elements of the cold response in zebrafish

The transcriptional programs of ectothermic teleosts are directly influenced by water temperature. However, the cis- and trans-factors governing cold responses are not well characterized. We profiled transcriptional changes in eight zebrafish tissues exposed to mildly and severely cold temperatures using RNA-Seq. A total of 1943 differentially expressed genes (DEGs) were...

TRFolder-W: a web server for telomerase RNA structure prediction in yeast genomes

Summary: TRFolder-W is a web server capable of predicting core structures of telomerase RNA (TR) in yeast genomes. TRFolder is a command-line Python toolkit for TR-specific structure prediction. We developed a web-version built on the django web framework, leveraging the work done previously, to include enhancements to increase flexibility of usage. To date, there are five core...

Self-similar structure of magnetized advection-dominated accretion flows and convection-dominated accretion flows

We study the effects of a global magnetic field on viscously rotating and vertically integrated accretion discs around compact objects using a self-similar treatment. We extend Akizuki & Fukue's work by discussing a general magnetic field with three components (r, ϕ, z) in advection-dominated accretion flows (ADAFs). We also investigate the effects of a global magnetic field on...

The BH3-mimetic ABT-737 sensitizes human melanoma cells to apoptosis induced by selective BRAF inhibitors but does not reverse acquired resistance

Although the introduction of selective v-Raf murine sarcoma viral oncogene homolog B1 (BRAF) inhibitors has been a major advance in treatment of metastatic melanoma, approximately 50% of patients have limited responses including stabilization of disease or no response at all. This study aims to identify a novel means of overcoming resistance of melanoma to killing by BRAF...

The melanoma-associated antigen MAGE-D2 suppresses TRAIL receptor 2 and protects against TRAIL-induced apoptosis in human melanoma cells

Emerging evidence has pointed to biological roles of melanoma-associated antigens (MAGEs) in cancer development, progression and resistance to treatment. However, the mechanisms involved remain to be fully elucidated. In this report, we show that one of the MAGE proteins, MAGE-D2, suppresses the expression of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death...

Effect of pooling samples on the efficiency of comparative studies using microarrays

Shu-Dong Zhang 0 Timothy W. Gant 0 0 MRC Toxicology Unit , Hodgkin Building, Lancaster Road , University of Leicester , Leicester , UK Motivation: Many biomedical experiments are carried out by

RanGTPase: A Candidate for Myc-Mediated Cancer Progression

Background Ras-related nuclear protein (Ran) is required for cancer cell survival in vitro and human cancer progression, but the molecular mechanisms are largely unknown.

A statistical framework for the design of microarray experiments and effective detection of differential gene expression

Motivation: Microarray experiments generate a high data volume. However, often due to financial or experimental considerations, e.g. lack of sample, there is little or no replication of the experiments or hybridizations. These factors combined with the intrinsic variability associated with the measurement of gene expression can result in an unsatisfactory detection rate of...

Increased PrLZ-mediated androgen receptor transactivation promotes prostate cancer growth at castration-resistant stage

Most advanced prostate cancers (PCa) will develop into the castration-resistant stage following androgen deprivation therapy, yet the molecular mechanisms remain unclear. In this study, we found PrLZ, a newly identified Prostate Leucine Zipper gene that is highly expressed in PCa could interact with the androgen receptor (AR) directly leading to enhance AR transactivation in the...

Glucose-regulated protein 78 antagonizes cisplatin and adriamycin in human melanoma cells

Peter Hersey 0 Xu Dong Zhang 0 0 Immunology and Oncology Unit, Room 443, Newcastle Misericordiae Hospital , David Maddison Clinical Sciences Building, Corner King and Watt Streets, Newcastle, New South

Airway Responses in Brown Norway Rats Following Inhalation Sensitization and Challenge with Trimellitic Anhydride

Trimellitic anhydride (TMA) is a cause of asthma in man. Dose-dependent TMA-specific IgE, histopathology, and airway responses after sensitization by inhalation were examined in the Brown Norway rat. Rats were exposed to 0.04, 0.4, 4, or 40 mg/m3 TMA aerosol for 10 min, once a week, over 10 weeks. All lower exposures were, subsequently, rechallenged to 40 mg/m3 TMA aerosol. All...

Evidence for a functional dimeric form of the PcrA helicase in DNA unwinding

PcrA helicase, a member of the superfamily 1, is an essential enzyme in many bacteria. The first crystal structures of helicases were obtained with PcrA. Based on structural and biochemical studies, it was proposed and then generally believed that PcrA is a monomeric helicase that unwinds DNA by an inchworm mechanism. But a functional state of PcrA from unwinding kinetics studies...

Thapsigargin sensitizes human melanoma cells to TRAIL-induced apoptosis by up-regulation of TRAIL-R2 through the unfolded protein response

also be addressed to Dr Xu Dong Zhang. Tel: 0 Fax: 0 Email: 0 0 Immunology and Oncology Unit, David Maddison Clinical Sciences Building, Newcastle Misericordiae Hospital , Cnr. King & Watt Streets

The Genome of a Mongolian Individual Reveals the Genetic Imprints of Mongolians on Modern Human Populations

Mongolians have played a significant role in modern human evolution, especially after the rise of Genghis Khan (1162[?]–1227). Although the social cultural impacts of Genghis Khan and the Mongolian population have been well documented, explorations of their genome structure and genetic imprints on other human populations have been lacking. We here present the genome of a...

Association of gene expression with sequential proliferation, differentiation and tumor formation in murine skin

Differential gene expression in two established initiation and promotion skin carcinogenesis models during promotion and tumor formation was determined by microarray technology with the purpose of distinguishing the genes more associated with neoplastic transformation from those linked with proliferation and differentiation. The first model utilized dimethylbenz[a]anthracene...

Structural and functional analyses of disease-causing missense mutations in Bloom syndrome protein

Bloom syndrome (BS) is an autosomal recessive disorder characterized by genomic instability and the early development of many types of cancer. Missense mutations have been identified in the BLM gene (encoding a RecQ helicase) in affected individuals, but the molecular mechanism and the structural basis of the effects of these mutations remain to be elucidated. We analysed five...

SALL1, the gene mutated in Townes–Brocks syndrome, encodes a transcriptional repressor which interacts with TRF1/PIN2 and localizes to pericentromeric heterochromatin

Zhang, Department of Medicine III, University of Munich, and GSF, Clinical Cooperative Group 'Leukemia' , Marchioninistrasse 25, 81377 Munchen , Germany 1 Institute of Anthropology and Human Genetics

Exposure of Brown Norway Rats to Diesel Exhaust Particles Prior to Ovalbumin (OVA) Sensitization Elicits IgE Adjuvant Activity but Attenuates OVA-Induced Airway Inflammation

Exposure to diesel exhaust particles (DEP) during the sensitization process has been shown to increase antigen-specific IgE production and aggravate allergic airway inflammation in human and animal models. In this study, we evaluated the effect of short-term DEP exposure on ovalbumin (OVA)-mediated responses using a post-sensitization model. Brown Norway rats were first exposed...