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5 papers found.
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A gene-signature progression approach to identifying candidate small-molecule cancer therapeutics with connectivity mapping

, UK 1 Centre for Cancer Research and Cell Biology (CCRCB), Queen's University Belfast , Belfast , UK 2 Peter W. Hamilton and Shu-Dong Zhang are joint senior authors 3 Scientific Computing Department

QUADrATiC: scalable gene expression connectivity mapping for repurposing FDA-approved therapeutics

contributor. Ken I. Mills and Shu-Dong Zhang are joint senior authors Background: Gene expression connectivity mapping has proven to be a powerful and flexible tool for research. Its application has been shown

cudaMap: a GPU accelerated program for gene expression connectivity mapping

Darragh G McArt 0 Peter Bankhead 0 Philip D Dunne Manuel Salto-Tellez Peter Hamilton Shu-Dong Zhang 0 Equal contributors Centre for Cancer Research and Cell Biology (CCRCB), Queen's University

sscMap: An extensible Java application for connecting small-molecule drugs using gene-expression signatures

Background Connectivity mapping is a process to recognize novel pharmacological and toxicological properties in small molecules by comparing their gene expression signatures with others in a database. A simple and robust method for connectivity mapping with increased specificity and sensitivity was recently developed, and its utility demonstrated using experimentally derived gene...

A simple and robust method for connecting small-molecule drugs using gene-expression signatures

Background Interaction of a drug or chemical with a biological system can result in a gene-expression profile or signature characteristic of the event. Using a suitably robust algorithm these signatures can potentially be used to connect molecules with similar pharmacological or toxicological properties by gene expression profile. Lamb et al first proposed the Connectivity Map...