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307 papers found.
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Apoptosis and Growth Inhibition in Malignant Lymphocytes After Treatment With Arsenic Trioxide at Clinically Achievable Concentrations

BACKGROUND: Arsenic trioxide (As2O3) can induce clinical remission in patients with acute promyelocytic leukemia via induction of differentiation and programmed cell death (apoptosis). We investigated the effects of As2O3 on a panel of malignant lymphocytes to determine whether growth-inhibitory and apoptotic effects of As2O3 can be observed in these cells at clinically...

Exposure of Brown Norway Rats to Diesel Exhaust Particles Prior to Ovalbumin (OVA) Sensitization Elicits IgE Adjuvant Activity but Attenuates OVA-Induced Airway Inflammation

Exposure to diesel exhaust particles (DEP) during the sensitization process has been shown to increase antigen-specific IgE production and aggravate allergic airway inflammation in human and animal models. In this study, we evaluated the effect of short-term DEP exposure on ovalbumin (OVA)-mediated responses using a post-sensitization model. Brown Norway rats were first exposed...

Identification of differentially expressed genes of primary spermatocyte against round spermatid isolated from human testis using the laser capture microdissection technique

The method of laser capture microdissection (LCM) combined with suppressive subtractive hybridization (SSH) was developed to isolate specific germ cells from human testis sections and to identify the genes expressed during differentiation and development. In the present study, over 10,000 primary spermatocytes and round spermatid cells were successfully isolated by LCM. Using the...

Expression and localization of VCX/Y proteins and their possible involvement in regulation of ribosome assembly during spermatogenesis

Union Medical College, 5 Dong Dan 3-tiao, Beijing 100005, ChinaSheng Wei ZOU, Xiao Dong ZHANG, Shi Ying MIAO, Qi SHENG & Lin Fang WANGNational Research Institute for Family Planing, WHO Collaboration ... Jian Chao ZHANG in:Nature Research journals • PubMed • Google ScholarSearch for Xiao Dong ZHANG in:Nature Research journals • PubMed • Google ScholarSearch for Shi Ying MIAO in:Nature Research journals

SALL1, the gene mutated in Townes–Brocks syndrome, encodes a transcriptional repressor which interacts with TRF1/PIN2 and localizes to pericentromeric heterochromatin

Zhang, Department of Medicine III, University of Munich, and GSF, Clinical Cooperative Group 'Leukemia' , Marchioninistrasse 25, 81377 Munchen , Germany 1 Institute of Anthropology and Human Genetics

A Mechanistic Paradigm for Broad-Spectrum Antivirals that Target Virus-Cell Fusion

LJ001 is a lipophilic thiazolidine derivative that inhibits the entry of numerous enveloped viruses at non-cytotoxic concentrations (IC50≤0.5 µM), and was posited to exploit the physiological difference between static viral membranes and biogenic cellular membranes. We now report on the molecular mechanism that results in LJ001's specific inhibition of virus-cell fusion. The...

Mapping susceptibility loci for alcohol consumption using number of grams of alcohol consumed per day as a phenotype measure

Background There is substantial evidence for a significant genetic component to the risk for alcoholism. However, susceptibility loci or genes for alcohol dependence remain largely unknown. To identify susceptibility loci for alcohol dependence, we selected 329 extended families from the Framingham Heart Study population in which at least one family member reported alcohol...

Erratum: Camelid genomes reveal evolution and adaptation to desert environments

Mohammed H. Abutarboush Yanping Xing Zhiyuan Xie Ali S. Alshanqeeti Yanru Zhang Qiulin Yao Badr M. Al-Shomrani Dong Zhang Jiang Li Manee M. Manee Zili Yang Linfeng Yang Yiyi Liu Jilin Zhang Musaad A

High-Density Genetic Linkage Map Construction and QTL Mapping of Grain Shape and Size in the Wheat Population Yanda1817 × Beinong6

High-density genetic linkage maps are necessary for precisely mapping quantitative trait loci (QTLs) controlling grain shape and size in wheat. By applying the Infinium iSelect 9K SNP assay, we have constructed a high-density genetic linkage map with 269 F 8 recombinant inbred lines (RILs) developed between a Chinese cornerstone wheat breeding parental line Yanda1817 and a high...

Neck Circumference Positively Related With Central Obesity, Overweight, and Metabolic Syndrome in Chinese Subjects With Type 2 Diabetes: Beijing Community Diabetes Study 4


Structural and functional analyses of disease-causing missense mutations in Bloom syndrome protein

Bloom syndrome (BS) is an autosomal recessive disorder characterized by genomic instability and the early development of many types of cancer. Missense mutations have been identified in the BLM gene (encoding a RecQ helicase) in affected individuals, but the molecular mechanism and the structural basis of the effects of these mutations remain to be elucidated. We analysed five...

A function blocking anti-mouse integrin α5β1 antibody inhibits angiogenesis and impedes tumor growth in vivo

Background Integrins are important adhesion molecules that regulate tumor and endothelial cell survival, proliferation and migration. The integrin α5β1 has been shown to play a critical role during angiogenesis. An inhibitor of this integrin, volociximab (M200), inhibits endothelial cell growth and movement in vitro, independent of the growth factor milieu, and inhibits tumor...

Association of gene expression with sequential proliferation, differentiation and tumor formation in murine skin

Differential gene expression in two established initiation and promotion skin carcinogenesis models during promotion and tumor formation was determined by microarray technology with the purpose of distinguishing the genes more associated with neoplastic transformation from those linked with proliferation and differentiation. The first model utilized dimethylbenz[a]anthracene...

Activation of ERK1/2 protects melanoma cells from TRAIL-induced apoptosis by inhibiting Smac/DIABLO release from mitochondria

2300, AustraliaXu Dong Zhang, Jodie M Borrow, Xi Yi Zhang, Tam Nguyen & Peter Hersey AuthorsSearch for Xu Dong Zhang in:Nature Research journals • PubMed • Google ScholarSearch for Jodie M Borrow

An association of a simultaneous nuclear and cytoplasmic localization of Fra-1 with breast malignancy

Background Overexpression of Fra-1 in fibroblasts causes anchorage-independent cell growth and oncogenic transformation. A high level of Fra-1 expression is found in various tumors and tumorigenic cell lines, suggesting that Fra-1 may be involved in malignant progression. This study aimed to investigate the significance of Fra-1 expression in breast carcinogenesis. Methods The...

The Genome of a Mongolian Individual Reveals the Genetic Imprints of Mongolians on Modern Human Populations

Mongolians have played a significant role in modern human evolution, especially after the rise of Genghis Khan (1162[?]–1227). Although the social cultural impacts of Genghis Khan and the Mongolian population have been well documented, explorations of their genome structure and genetic imprints on other human populations have been lacking. We here present the genome of a...

A high-density genetic map of Arachis duranensis, a diploid ancestor of cultivated peanut

Zhang Sameer Khanal Adam F Heesacker Nelly Khalilian Andrew D Farmer Noelia Carrasquilla-Garcia R Varma Penmetsa Douglas Cook H Thomas Stalker Niels Nielsen Peggy Ozias-Akins 0 Steven J Knapp 0 Department

Association between APOC1 Polymorphism and Alzheimer’s Disease: A Case-Control Study and Meta-Analysis

ZY SP. Performed the experiments: QZ FZ ZL CZ Wei-dong Zheng LS NW FMdA MF XH JH WJ CY XS XZ GP YY HX Wan-dong Zhang CH ZY SP. Analyzed the data: QZ FZ LS NW FMdA MF XH ZY SP. Contributed reagents ... / materials/analysis tools: QZ FZ ZL CZ Wei-dong Zheng LS NW FMdA MF XH JH WJ CY XS XZ GP YY HX Wan-dong Zhang CH ZY SP. Wrote the paper: QZ FMdA ZY SP. genes APOE , APOC1 and ACE in a sample population from

Mcl-1, Bcl-XL and Stat3 expression are associated with progression of melanoma whereas Bcl-2, AP-2 and MITF levels decrease during progression of melanoma

Members of the Bcl-2 family of antiapoptotic proteins (Bcl-2, Bcl-XL and Mcl-1) are key regulators of apoptosis. The purpose of the present study was to examine and better define the role of Bcl-2, Bcl-XL and Mcl-1 in the progression of melanoma. Immunohistochemical staining for Bcl-2, Bcl-XL and Mcl-1 was performed on paraffin sections of 100 cases of benign nevi, primary...

Thapsigargin sensitizes human melanoma cells to TRAIL-induced apoptosis by up-regulation of TRAIL-R2 through the unfolded protein response

also be addressed to Dr Xu Dong Zhang. Tel: 0 Fax: 0 Email: 0 0 Immunology and Oncology Unit, David Maddison Clinical Sciences Building, Newcastle Misericordiae Hospital , Cnr. King & Watt Streets