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Comparative analysis of bla KPC-2- and rmtB-carrying IncFII-family pKPC-LK30/pHN7A8 hybrid plasmids from Klebsiella pneumoniae CG258 strains disseminated among multiple Chinese hospitals

Comparative analysis of bla KPC-2- and rmtB-carrying IncFII-family pKPC-LK30/pHN7A8 hybrid plasmids from Klebsiella pneumoniae CG258 strains disseminated among multiple Chinese hospitals Lining Shi,1,* Jiao Feng,2,* Zhe Zhan,2 Yuzong Zhao,2,3 Haijian Zhou,4 Haifeng Mao,5 Yingjie Gao,6 Ying Zhang,7 Zhe Yin,2 Bo Gao,2 Yigang Tong,2 Yanping Luo,7 Defu Zhang,2,3 Dongsheng Zhou2...

Three-dimensional printing model improves morphological understanding in acetabular fracture learning: A multicenter, randomized, controlled study

Zhang. Investigation: Yu He. Methodology: Wenhao Song, Yaoshen Zhang. Project administration: Qiang Zhang, Dongsheng Zhou, Xi Zhou, Yu He. Resources: Wenhao Song. Software: Wenhao Song, Yaoshen Zhang ... . Supervision: Qiang Zhang, Dongsheng Zhou, Xi Zhou, Yu He. Validation: Wenhao Song, Qiang Zhang. Writing ± original draft: Zhenfei Huang, Wenhao Song, Yaoshen Zhang, Xi Zhou, Yu He. Writing ± review & editing

Obstacle avoidance planning of space manipulator end-effector based on improved ant colony algorithm

manuscript; Dongsheng Zhou and Qiang Zhang contributed to the method, direction, writing and content and also revised the manuscript. All authors read and approved the final manuscript. Acknowledgements This

Use of recombinant porcine β-defensin 2 as a medicated feed additive for weaned piglets

Post-weaning diarrhoea (PWD) in piglets is associated with colonization of the intestine with bacterial pathogens. In this study, we evaluated the use of recombinant porcine β-defensin 2 (rpBD2) as a medicated feed additive for weaned piglets. The crude extract from the culture supernatant of rpBD2-expressing Pichia pastoris was used as a medicated feed additive for weaned...

A monocyte/granulocyte to lymphocyte ratio predicts survival in patients with hepatocellular carcinoma

carcinoma Dongsheng Zhou Yaojun Zhang Li Xu Zhongguo Zhou Junting Huang Minshan Chen Scientific RepoRts OPEN Conflict that the derived neutrophil lymphocyte (dNLR) has prognostic value in patients with a

Plasmid pPCP1-derived sRNA HmsA promotes biofilm formation of Yersinia pestis

Background The ability of Yersinia pestis to form a biofilm is an important characteristic in flea transmission of this pathogen. Y. pestis laterally acquired two plasmids (pPCP1and pMT1) and the ability to form biofilms when it evolved from Yersinia pseudotuberculosis. Small regulatory RNAs (sRNAs) are thought to play a crucial role in the processes of biofilm formation and...

Reproductive Hormone and Transcriptomic Responses of Pituitary Tissue in Anestrus Gilts Induced by Nutrient Restriction

The onset of estrus is a critical sign of female sexual maturity. The pituitary plays a vital role in this process by the secretion of reproductive hormones. To investigate the effects of nutrient restriction on reproductive function and the underlying mechanisms involved, deep RNA sequencing of pituitary gland tissue was carried out to determine the differentially expressed...

Medial approach to treat humeral mid-shaft fractures: a retrospective study

Background Plate fixation is the gold standard for diaphyseal fracture management, and the anterolateral approach is widely used by reconstructive surgeons. However, the outcomes of humeral shaft fracture fixation using a medial approach are rarely reported. The aim of this study is to explore the management and outcomes of humeral mid-shaft fractures fixed through a medial...

Transcriptional regulation of the waaAE-coaD operon by PhoP and RcsAB in Yersinia pestis biovar Microtus

) Editing. Lei Liu, Nan Fang, Yicheng Sun, Huiying Yang, Yiquan Zhang, Yanping Han, Dongsheng Zhou, and Ruifu Yang declare that they have no conflict of interest. This article does not contain any studies

Environmental enrichment and abstinence attenuate ketamine-induced cardiac and renal toxicity

• PubMed • Google ScholarSearch for Dongsheng Zhou in:Nature Research journals • PubMed • Google ScholarSearch for Wenwen Shen in:Nature Research journals • PubMed • Google ScholarSearch for Wenhua Zhou

Common variants at 2q11.2, 8q21.3, and 11q13.2 are associated with major mood disorders

Bipolar disorder (BPD) and major depressive disorder (MDD) are primary major mood disorders. Recent studies suggest that they share certain psychopathological features and common risk genes, but unraveling the full genetic architecture underlying the risk of major mood disorders remains an important scientific task. The public genome-wide association study (GWAS) data sets offer...

Epidemic Clones, Oceanic Gene Pools, and Eco-LD in the Free Living Marine Pathogen Vibrio parahaemolyticus

We investigated global patterns of variation in 157 whole-genome sequences of Vibrio parahaemolyticus, a free-living and seafood associated marine bacterium. Pandemic clones, responsible for recent outbreaks of gastroenteritis in humans, have spread globally. However, there are oceanic gene pools, one located in the oceans surrounding Asia and another in the Mexican Gulf...

Transcriptional Regulation of opaR, qrr2–4 and aphA by the Master Quorum-Sensing Regulator OpaR in Vibrio parahaemolyticus

Background Vibrio parahaemolyticus is a leading cause of infectious diarrhea and enterogastritis via the fecal-oral route. V. harveyi is a pathogen of fishes and invertebrates, and has been used as a model for quorum sensing (QS) studies. LuxR is the master QS regulator (MQSR) of V. harveyi, and LuxR-dependent expression of its own gene, qrr2–4 and aphA have been established in V...

Isolation and Characterization of 89K Pathogenicity Island-Positive ST-7 Strains of Streptococcus suis Serotype 2 from Healthy Pigs, Northeast China

 Xuehui Cai,1 Dongsheng Zhou,2 and Yongqiang Jiang2 1National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Science, Harbin 150001, China

Experience-based behavioral and chemosensory changes in the generalist insect herbivore Helicoverpa armigera exposed to two deterrent plant chemicals

Behavioral and electrophysiological responses of larvae of the polyphagous moth species Helicoverpa armigera to two plant-derived allelochemicals were studied, both in larvae that had been reared on a diet devoid of these compounds and in larvae previously exposed to these compounds. In dual-choice cotton leaf disk and pepper fruit disk arena assays, caterpillars reared on a...

Expression of the Type VI Secretion System 1 Component Hcp1 Is Indirectly Repressed by OpaR in Vibrio parahaemolyticus

The type VI secretion system (T6SS) is bacterial protein injection machinery with roles in virulence, symbiosis, interbacterial interaction, antipathogenesis, and environmental stress responses. There are two T6SS loci, T6SS1 and T6SS2, in the two chromosomes of Vibrio parahaemolyticus, respectively. This work disclosed that the master quorum sensing (QS) regulator OpaR repressed...

Expression of the Type VI Secretion System 1 Component Hcp1 Is Indirectly Repressed by OpaR in Vibrio parahaemolyticus

The type VI secretion system (T6SS) is bacterial protein injection machinery with roles in virulence, symbiosis, interbacterial interaction, antipathogenesis, and environmental stress responses. There are two T6SS loci, T6SS1 and T6SS2, in the two chromosomes of Vibrio parahaemolyticus, respectively. This work disclosed that the master quorum sensing (QS) regulator OpaR repressed...

Epigenetic Regulation of BMP2 by 1,25-dihydroxyvitamin D3 through DNA Methylation and Histone Modification

Genetic hypercalciuric stone-forming (GHS) rats have increased intestinal Ca absorption, decreased renal tubule Ca reabsorption and low bone mass, all of which are mediated at least in part by elevated tissue levels of the vitamin D receptor (VDR). Both 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) and bone morphogenetic protein 2 (BMP2) are critical for normal maintenance of bone...

Cell Density- and Quorum Sensing-Dependent Expression of Type VI Secretion System 2 in Vibrio parahaemolyticus

the QS regulon members in V. parahaemolyticus. - Competing interests: Co-author Dongsheng Zhou is a PLOS ONE Editorial Board member. This does not alter the authors adherence to all the PLOS ONE

Identification of Gene Clusters Associated with Host Adaptation and Antibiotic Resistance in Chinese Staphylococcus aureus Isolates by Microarray-Based Comparative Genomics

A comparative genomic microarray comprising 2,457 genes from two whole genomes of S. aureus was employed for the comparative genome hybridization analysis of 50 strains of divergent clonal lineages, including methicillin-resistant S. aureus (MRSA), methicillin-susceptible S. aureus (MSSA), and swine strains in China. Large-scale validation was confirmed via polymerase chain...