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Influence of high glucose on mesangial cell-derived exosome composition, secretion and cell communication

Aparecida Boim. Investigation: Antonio da Silva Novaes, Fernanda Teixeira Borges. Methodology: Antonio da Silva Novaes, Marcos Vinicios Salles Dias, Fernanda Teixeira Borges, Edgar Maquigussa, Vanessa Varela

Precocious obesity predisposes the development of more severe cisplatin-induced acute kidney injury in young adult mice

Obesity and its consequences can damage the kidney over time. However, less is known about the impact of developing overweight/obesity during childhood on the kidney in adulthood and the renal impact of a superimposed acute kidney injury (AKI). This study evaluated the effect of obesity induced by a high-fat diet initiated soon after weaning on the adult life of mice and their...

Inhibition of cellular transdifferentiation by losartan minimizes but does not reverse type 2 diabetes-induced renal fibrosis

Hypothesis/Introduction: Transformer Growth Factor (TGF-β1) and angiotensin II (AngII) induce epithelial mesenchymal transition (EMT) and myofibroblastic transdifferentiation (MFT) contributing to renal fibrosis. The present study evaluated the capacity of an AT1 receptor blocker (losartan) to induce the regression of pre-existing fibrosis via interference with MFT and EMT in a...

Chronic Nicotine Exposure Abolishes Maternal Systemic and Renal Adaptations to Pregnancy in Rats

Pregnancy is characterized by maternal systemic and intrarenal vasodilation, leading to increases in the renal plasma flow (RPF) and glomerular filtration rate (GFR). These responses are mainly mediated by nitric oxide (NO) and relaxin. The impact of cigarette smoking on the maternal adaptations to pregnancy is unclear. Here we evaluated the effects of chronic exposure to...

(Pro)renin receptor: another member of the system controlled by angiotensin II?

The prorenin receptor [(P)RR] is upregulated in the diabetic kidney and has been implicated in the high glucose (HG)-induced overproduction of profibrotic molecules by mesangial cells (MCs), which is mediated by ERK1/2 phosphorylation. The regulation of (P)RR gene transcription and the mechanisms by which HG increases (P)RR gene expression are not fully understood. Because...

Mesenchymal Stem Cells (MSC) Prevented the Progression of Renovascular Hypertension, Improved Renal Function and Architecture

Renovascular hypertension induced by 2 Kidney-1 Clip (2K-1C) is a renin-angiotensin-system (RAS)-dependent model, leading to renal vascular rarefaction and renal failure. RAS inhibitors are not able to reduce arterial pressure (AP) and/or preserve the renal function, and thus, alternative therapies are needed. Three weeks after left renal artery occlusion, fluorescently tagged...

EXPERIMENTAL KIDNEY INJURY MECHANISMS

Introduction and Aims: Chronic stenosis of renal artery leads to chronic renal hypoxia, renovascular hypertension, renal vascular rarefaction, fibrosis and renal failure. Previous data from our Laboratory showed beneficial effects of mesenchymal stem cells (MSC) in the reconstruction of renal parenchyma of the stenotic kidney, improving the vascular rarefaction and fibrosis. Here...

Hypertension

Introduction and Aims: Renovascular hypertension induced by 2 Kidney-1 Clip (2K-1C) is a renin-angiotensin-system (RAS)-dependent model, leading to vascular rarefaction and renal failure, however, the pathophysiological mechanisms responsible for development and maintenance of 2K-1C model remain undefined, and thus, alternative therapies are needed. This work investigated the...

Hypertension - experimental models

Introduction and Aims: Whereas ACE2 deletion worsens kidney injury; its amplification ameliorates diabetic nephropathy. We previously showed that circulating ACE2 activity is increased in male diabetic NOD mice. The effect of gonadectomy in diabetic ACE2 knockout (ACE2KO) male mice has not been previously studied. Methods: We study the effect of ACE2 deletion on systolic blood...

Cell signalling / Pathophysiology

Introduction and Aims: Chronic kidney disease (CKD) markedly increases cardiovascular risk. Tissue Factor (TF), whose levels are elevated in CKD patients, may participate in the development of cardiovascular diseases.We hypothesized that indolic uremic solutes, indoxyl sulfate (IS) and indole-3-acetic acid (IAA), are involved in increased TF production. Methods: IAA, IS and...