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Use of medicines and health services for chronic obstructive pulmonary disease among a cohort of Australians over 50 years

Use of medicines and health services for chronic obstructive pulmonary disease among a cohort of Australians over 50 years Renly Lim, Mhairi Kerr, Elizabeth E Roughead Quality Use of Medicines and

The Risk of Hip Fracture Due to Mirtazapine Exposure When Switching Antidepressants or Using Other Antidepressants as Add-On Therapy

Background Antidepressants are associated with adverse effects such as sedation and hypotension, which can result in falls and fractures. Few studies have assessed the risk of hip fracture due to mirtazapine, and no known studies have assessed whether the risk of hip fracture is higher in patients taking other antidepressant medicines in combination with mirtazapine. Objectives...

Risk of Hip Fracture in Older People Using Selective Serotonin Reuptake Inhibitors and Other Psychoactive Medicines Concurrently: A Matched Case–Control Study in Australia

Background Few studies have assessed the risk of hip fracture following concurrent use of psychoactive medicines, and none has investigated combinations with selective serotonin reuptake inhibitors. Objectives To assess the risk of hip fracture in older people as a result of concurrent use of selective serotonin reuptake inhibitors and other psychoactive medicines. Methods A...

Impact on Drug Safety of Variation in Adherence: The Need for Routinely Reporting Measures of Dose Intensity in Medication Safety Studies Using Electronic Health Data

E. Roughead Randomized controlled trials always report the dose assessed and usually include a measure of adherence. By comparison, observational studies assessing medication safety often fail to ... Nicole L. Pratt 0 1 0 Quality Use of Medicines and Pharmacy Research Centre, Sansom Institute for Health Research, University of South Australia , GPO Box 2471, Adelaide, SA 5001 , Australia 1 & Elizabeth

The performance of sequence symmetry analysis as a tool for post-market surveillance of newly marketed medicines: a simulation study

Background Sequence symmetry analysis (SSA) is a potential tool for rapid detection of adverse drug events (ADRs) associated with newly marketed medicines utilizing computerized claims data. SSA is robust to patient specific confounders but it is sensitive to the underlying utilization trends in the medicines of interest. Methods to adjust for utilisation trends have been...

Association between Ophthalmic Timolol and Hospitalisation for Bradycardia

’ Contribution Elizabeth E. Roughead, Nicole L. Pratt, and Emmae N. Ramsay had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis ... . Elizabeth E. Roughead, Nicole L. Pratt, Emmae N. Ramsay, Lisa M. Kalisch Ellett, and Tuan A. Nguyen carried out study concept and design. Elizabeth E. Roughead carried out acquisition of data. Nicole L. Pratt

Early discontinuation of endocrine therapy for breast cancer: who is at risk in clinical practice?

Anna Kemp 0 David B Preen 0 Christobel Saunders Frances Boyle Max Bulsara Eva Malacova 0 Elizabeth E Roughead 0 Centre for Health Services Research, School of Population Health, The University of

Proton pump inhibitors and the risk of pneumonia: a comparison of cohort and self-controlled case series designs

Background To compare the results of a new-user cohort study design and the self-controlled case series (SCCS) design using the risk of hospitalisation for pneumonia in those dispensed proton pump inhibitors compared to those unexposed as a case study. Methods The Australian Government Department of Veterans’ Affairs administrative claims database was used. Exposure to proton...

Choice of observational study design impacts on measurement of antipsychotic risks in the elderly: a systematic review

Nicole Pratt 0 Elizabeth E Roughead 0 Amy Salter Philip Ryan 0 Quality Use of Medicines and Pharmacy Research Centre; Sansom Institute, University of South Australia , Adelaide , Australia

Transient ischaemic attack and ischaemic stroke: constructing episodes of care using hospital claims data

Roughead 0 Andrew L Gilbert 0 0 Quality Use of Medicines and Pharmacy Research Centre, Sansom Institute for Health Research, University of South Australia , GPO Box 2471, Adelaide, SA 5001 , Australia 1

Comorbid Diabetes and COPD: Impact of corticosteroid use on diabetes complications

GILLIAN E. CAUGHEY PHD ADRIAN K. PREISS PHD AGNES I. VITRY PHD ANDREW L. GILBERT PHD ELIZABETH E. ROUGHEAD PHD E p i d e m i o l o g y / H e a l t h OBJECTIVEdTo identify if there is a dose

Association Between Use of Multiple Psychoactive Medicines and Hospitalization for Falls: Retrospective Analysis of a Large Healthcare Claim Database

this manuscript. Conflict of interest Nicole L. Pratt, Emmae N. Ramsay, Lisa M. Kalisch Ellett, Tuan A. Nguyen, John D. Barratt and Elizabeth E. Roughead have no conflicts of interest that are directly

Ranibizumab and Risk of Hospitalisation for Ischaemic Stroke and Myocardial Infarction in Patients with Age-Related Macular Degeneration: A Self-Controlled Case-Series Analysis

, Stephen Graves and Elizabeth E. Roughead have no conflicts of interest that are directly relevant to the content of this study. Open Access This article is distributed under the terms of the Creative

Women Commencing Anastrozole, Letrozole or Tamoxifen for Early Breast Cancer: The Impact of Comorbidity and Demographics on Initial Choice

Background Australian clinical guidelines recommend endocrine therapy for all women with hormone-dependent early breast cancer. Guidelines specify tamoxifen as first-line therapy for pre-menopausal women, and tamoxifen or an aromatase inhibitor (AI) for post-menopausal women depending on the risk of recurrence based on tumour characteristics including size. Therapies have...

Quality of claims, references and the presentation of risk results in medical journal advertising: a comparative study in Australia, Malaysia and the United States

Background Journal advertising is used by pharmaceutical companies to disseminate medicine information to doctors. The quality of claims, references and the presentation of risk results in Australia and the US has been questioned in several studies. No recent evidence is available on the quality of claims, references and the presentation of risk results in journal advertising in...

Ascertaining invasive breast cancer cases; the validity of administrative and self-reported data sources in Australia

Background Statutory State-based cancer registries are considered the ‘gold standard’ for researchers identifying cancer cases in Australia, but research using self-report or administrative health datasets (e.g. hospital records) may not have linkage to a Cancer Registry and need to identify cases. This study investigated the validity of administrative and self-reported data...

Quality of Pharmaceutical Advertisements in Medical Journals: A Systematic Review

Background Journal advertising is one of the main sources of medicines information to doctors. Despite the availability of regulations and controls of drug promotion worldwide, information on medicines provided in journal advertising has been criticized in several studies for being of poor quality. However, no attempt has been made to systematically summarise this body of...

A self-controlled case series to assess the effectiveness of beta blockers for heart failure in reducing hospitalisations in the elderly

Background To determine the suitability of using the self-controlled case series design to assess improvements in health outcomes using the effectiveness of beta blockers for heart failure in reducing hospitalisations as the example. Methods The Australian Government Department of Veterans' Affairs administrative claims database was used to undertake a self-controlled case-series...

Medicines information provided by pharmaceutical representatives: a comparative study in Australia and Malaysia

Background Pharmaceutical representatives provide medicines information on their promoted products to doctors. However, studies have shown that the quality of this information is often low. No study has assessed the medicines information provided by pharmaceutical representatives to doctors in Malaysia and no recent evidence in Australia is present. We aimed to compare the...

Bridging evidence-practice gaps: improving use of medicines in elderly Australian veterans

Background The Australian Government Department of Veterans’ Affairs (DVA) funds an ongoing health promotion based program to improve use of medicines and related health services, which implements interventions that include audit and feedback in the form of patient-specific feedback generated from administrative claims records. We aimed to determine changes in medicine use as a...