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The Epigenetic Landscape of Acute Myeloid Leukemia

Received 25 October 2013; Revised 27 January 2014; Accepted 3 February 2014; Published 23 March 2014 Academic Editor: Myriam Labopin Copyright © 2014 Emma Conway O’Brien et al. This is an open access

The RAG Model: A New Paradigm for Genetic Risk Stratification in Multiple Myeloma

Molecular studies have shown that multiple myeloma is a highly genetically heterogonous disease which may manifest itself as any number of diverse subtypes each with variable clinicopathological features and outcomes. Given this genetic heterogeneity, a universal approach to treatment of myeloma is unlikely to be successful for all patients and instead we should strive for the...

The RAG Model: A New Paradigm for Genetic Risk Stratification in Multiple Myeloma

Molecular studies have shown that multiple myeloma is a highly genetically heterogonous disease which may manifest itself as any number of diverse subtypes each with variable clinicopathological features and outcomes. Given this genetic heterogeneity, a universal approach to treatment of myeloma is unlikely to be successful for all patients and instead we should strive for the...