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Endostatin Polymorphism 4349G/A(D104N) Is Not Associated with Aggressiveness of Disease in Prostate Cancer

Disease Markers Endostatin polymorphism 4349G/A(D104N) is not associated with aggressiveness of disease in prostate cancer He Cheng Li Qiu Yin Cai Eric T. Shinohara Hui Cai Carolyn Cao Zuo Fei Wang

Endostatin Polymorphism 4349G/A(D104N) is not Associated with Aggressiveness of Disease in Postate Cancer

Endostatin is an important inhibitory molecule which mediates the sequential steps involved in angiogenesis. Lower level or impaired function of endostatin is associated with a higher risk of developing malignant solid tumors and with a worse prognosis of the disease. The endostatin N104 polymorphism might be associated with an impaired ability to inhibit angiogenesis. We...

Endostatin Polymorphism 4349G/A(D104N) Is Not Associated with Aggressiveness of Disease in Prostate Cancer

Disease Markers Endostatin polymorphism 4349G/A(D104N) is not associated with aggressiveness of disease in prostate cancer He Cheng Li Qiu Yin Cai Eric T. Shinohara Hui Cai Carolyn Cao Zuo Fei Wang

Endostatin Polymorphism 4349G/A(D104N) is not Associated with Aggressiveness of Disease in Postate Cancer

Endostatin is an important inhibitory molecule which mediates the sequential steps involved in angiogenesis. Lower level or impaired function of endostatin is associated with a higher risk of developing malignant solid tumors and with a worse prognosis of the disease. The endostatin N104 polymorphism might be associated with an impaired ability to inhibit angiogenesis. We...

Endostatin Polymorphism 4349G/A(D104N) Is Not Associated with Aggressiveness of Disease in Prostate Cancer

Disease Markers Endostatin polymorphism 4349G/A(D104N) is not associated with aggressiveness of disease in prostate cancer He Cheng Li Qiu Yin Cai Eric T. Shinohara Hui Cai Carolyn Cao Zuo Fei Wang

Endostatin Polymorphism 4349G/A(D104N) is not Associated with Aggressiveness of Disease in Postate Cancer

Endostatin is an important inhibitory molecule which mediates the sequential steps involved in angiogenesis. Lower level or impaired function of endostatin is associated with a higher risk of developing malignant solid tumors and with a worse prognosis of the disease. The endostatin N104 polymorphism might be associated with an impaired ability to inhibit angiogenesis. We...

Long-term outcomes and late effects for childhood and young adulthood intracranial germinomas

Background Pediatric and young adult central nervous system (CNS) germinomas have favorable cure rates. However, long-term follow-up data are limited because of the rarity of this tumor. We report the long-term overall survival (OS) and causes of late mortality for these patients.

Outcome for Children with Metastatic Solid Tumors over the Last Four Decades

Background Outcomes for pediatric solid tumors have significantly improved over the last 30 years. However, much of this improvement is due to improved outcome for patients with localized disease. Here we evaluate overall survival (OS) for pediatric patients with metastatic disease over the last 40 years. Procedure The United States Surveillance, Epidemiology, and End Results...

Short Course High Dose Radiotherapy in the Treatment of Anaplastic Thyroid Carcinoma

Purpose. Anaplastic thyroid carcinoma (ATC) is a rare but aggressive tumor with limited survival. To date, the ideal radiation treatment schedule, one that balances limited survival with treatment efficacy, remains undefined. In this retrospective series we investigate the effectiveness and tolerability of hypofractionated radiation therapy in the treatment of ATC. Methods. 17...

Short Course High Dose Radiotherapy in the Treatment of Anaplastic Thyroid Carcinoma

Purpose. Anaplastic thyroid carcinoma (ATC) is a rare but aggressive tumor with limited survival. To date, the ideal radiation treatment schedule, one that balances limited survival with treatment efficacy, remains undefined. In this retrospective series we investigate the effectiveness and tolerability of hypofractionated radiation therapy in the treatment of ATC. Methods. 17...

Esophageal cancer in a young woman with bulimia nervosa: a case report

Adenocarcinoma of the esophagus has increased dramatically within the United States and continues to have a poor prognosis despite aggressive treatment. Identifying potential risk factors is critical for the early detection and treatment of this disease. The present case report describes a very young woman who developed adenocarcinoma of the esophagus after only a brief history...

Esophageal cancer in a young woman with bulimia nervosa: a case report

Adenocarcinoma of the esophagus has increased dramatically within the United States and continues to have a poor prognosis despite aggressive treatment. Identifying potential risk factors is critical for the early detection and treatment of this disease. The present case report describes a very young woman who developed adenocarcinoma of the esophagus after only a brief history...

The use of antisense oligonucleotides in evaluating survivin as a therapeutic target for radiation sensitization in lung cancer

Elucidating the mechanism of over and under expression of proteins is critical in developing a better understanding of cancer. Multiple techniques are used to examine differential expression of proteins in cells and assess changes in protein expression in response to therapies such as radiation. Reduced expression can be caused by protein inactivation, mRNA instability, or...

Enhanced radiation damage of tumor vasculature by mTOR inhibitors

It is known that radiation activates the phosphoinositol-3 kinase (PI3K)/Akt pathway and that inhibition of PI3K or Akt sensitizes tumor vasculature to radiotherapy. Mammalian target of rapamycin (mTOR) is a downstream target of Akt, and we hypothesized that irradiation activates mTOR signaling in both glioma and endothelial cells (ECs) and that radiosensitization results from...