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Alcohol consumption and leukocyte telomere length

The relationship between alcohol consumption and mortality generally exhibits a U-shaped curve. The longevity observed with moderate alcohol consumption may be explained by other confounding factors, and, if such a relationship is present, the mechanism is not well understood. Indeed, the optimal amount of alcohol consumption for health has yet to be determined. Leukocyte...

Cigarette and e-cigarette dual use and risk of cardiopulmonary symptoms in the Health eHeart Study

Conceptualization: Julie B. Wang, Gregory M. Marcus. Formal analysis: Julie B. Wang, Gregory Nah, Eric Vittinghoff, Mark J. Pletcher, Gregory M. Marcus. Funding acquisition: Julie B. Wang, Jeffrey E. Olgin, Mark J ... . Pletcher, Gregory M. Marcus. Investigation: Julie B. Wang, Gregory M. Marcus. Methodology: Julie B. Wang, Eric Vittinghoff, Mark J. Pletcher, Gregory M. Marcus. Resources: Julie B. Wang, Jeffrey E. Olgin

Trends in rate of acute myocardial infarction among patients aged <30 years

the School of Medicine, Johns Hopkins University , 720 Rutland Avenue, Baltimore, Maryland , USA 2 Xiaofan Guo, Eric Vittinghoff, and Mark J. Pletcher are at the Department of Epidemiology and

Past alcohol consumption and incident atrial fibrillation: The Atherosclerosis Risk in Communities (ARIC) Study

, Gregory M. Marcus. Data curation: Shalini Dixit, Eric Vittinghoff. Formal analysis: Shalini Dixit, Eric Vittinghoff, Gregory M. Marcus. Funding acquisition: Shalini Dixit, Alvaro Alonso, Gregory M ... . Chen. Visualization: Shalini Dixit, Gregory M. Marcus. Writing ± original draft: Shalini Dixit, Gregory M. Marcus. Writing ± review & editing: Shalini Dixit, Alvaro Alonso, Eric Vittinghoff, Elsayed

Behavioral intervention to reduce opioid overdose among high-risk persons with opioid use disorder: A pilot randomized controlled trial

Contributions Conceptualization: Phillip Oliver Coffin, Glenn-Milo Santos, Tim Matheson, Eric Vittinghoff. Data curation: Chris Rowe. Formal analysis: Glenn-Milo Santos, Chris Rowe, Eric Vittinghoff. Funding ... Behar. Writing ± original draft: Phillip Oliver Coffin, Glenn-Milo Santos, Tim Matheson, Chris Rowe, Talia Rubin, Janelle Silvis, Eric Vittinghoff. Writing ± review & editing: Phillip Oliver Coffin

New insights into discrepancies between self-reported and accelerometer-measured moderate to vigorous physical activity among women – the mPED trial

0 William Haskell 2 Eric Vittinghoff 1 0 Institute for Health & Aging / Department of Physiological Nursing, School of Nursing, University of California, San Francisco , 3333 California Street, Suite

Volunteer Participation in the Health eHeart Study: A Comparison with the US Population

Direct volunteer “eCohort” recruitment can be an efficient way of recruiting large numbers of participants, but there is potential for volunteer bias. We compared self-selected participants in the Health eHeart Study to participants in the National Health And Nutrition Examination Survey (NHANES) 2013–14, a cross-sectional survey of the US population. Compared with the US...

A complex intervention to improve implementation of World Health Organization guidelines for diagnosis of severe illness in low-income settings: a quasi-experimental study from Uganda

To improve management of severely ill hospitalized patients in low-income settings, the World Health Organization (WHO) established a triage tool called “Quick Check” to provide clinicians with a rapid, standardized approach to identify patients with severe illness based on recognition of abnormal vital signs. Despite the availability of these guidelines, recognition of severe...

Comparing pharmacologic measures of tenofovir exposure in a U.S. pre-exposure prophylaxis randomized trial

publish this manuscript. Sanjiv M. Baxi declares that he has no conflict of interest. Eric Vittinghoff declares that he has no conflict of interest. Peter Bacchetti declares that he has no conflict of ... Infections, San Francisco, CA, USA, February 16±19, 2010. Author Contributions Conceptualization: Sanjiv M. Baxi, Eric Vittinghoff, Peter Bacchetti, Kata Chillag, Ryan Wiegand, Peter L. Anderson, Robert

Young Adult Exposure to Cardiovascular Risk Factors and Risk of Events Later in Life: The Framingham Offspring Study

Background It is unclear whether coronary heart disease (CHD) risk factor exposure during early adulthood contributes to CHD risk later in life. Our objective was to analyze whether extent of early adult exposures to systolic and diastolic blood pressure (SBP, DBP) and low-and high-density lipoprotein cholesterol (LDL, HDL) are independent predictors of CHD events later in life...

Risks of Hemolysis in Glucose-6-Phosphate Dehydrogenase Deficient Infants Exposed to Chlorproguanil-Dapsone, Mefloquine and Sulfadoxine-Pyrimethamine as Part of Intermittent Presumptive Treatment of Malaria in Infants

Background Chlorproguanil-dapsone (CD) has been linked to hemolysis in symptomatic glucose-6-phosphate dehydrogenase deficient (G6PDd) children. Few studies have explored the effects of G6PD status on hemolysis in children treated with Intermittent Preventive Treatment in infants (IPTi) antimalarial regimens. We sought to examine the joint effects of G6PD status and IPTi...

Health status as a potential mediator of the association between hemodialysis vascular access and mortality

Background It is unknown whether the selection of healthier patients for ateriovenous fistula (AVF) placement explains higher observed catheter-associated mortality among elderly hemodialysis patients.

Correction: Determinants of the creatinine clearance to glomerular filtration rate ratio in patients with chronic kidney disease: a cross-sectional study

After the publication of our paper Lin et al. “Determinants of the creatinine clearance to glomerular filtration rate ratio in patients with chronic kidney disease: a cross-sectional study” BMC Nephrology 2013, 14:268, we became aware of errors in the manuscript arising from to a misunderstanding of serum creatinine calibration in the released Chronic Renal Insufficiency Cohort...

Anemia and risk for cognitive decline in chronic kidney disease

Background Anemia is common among patients with chronic kidney disease (CKD) but its health consequences are poorly defined. The aim of this study was to determine the relationship between anemia and cognitive decline in older adults with CKD. Methods We studied a subgroup of 762 adults age ≥55 years with CKD participating in the Chronic Renal Insufficiency Cohort (CRIC) study...

Racial Differences in Left Atrial Size: Results from the Coronary Artery Risk Development in Young Adults (CARDIA) Study

Whites have an increased risk of atrial fibrillation (AF) compared to Blacks. The mechanism underlying this association is unknown. Left atrial (LA) size is an important AF risk factor, and studies in older adults suggest Whites have larger LA diameters. However, because AF itself causes LA dilation, LA size differences may be due to greater subclinical AF among older Whites. We...

Development of a pharmacovigilance safety monitoring tool for the rollout of single low-dose primaquine and artemether-lumefantrine to treat Plasmodium falciparum infections in Swaziland: a pilot study

Background Countries remain reluctant to adopt the 2012 World Health Organization recommendation for single low-dose (0.25 mg/kg) primaquine (SLD PQ) for Plasmodium falciparum transmission-blocking due to concerns over drug-related haemolysis risk, especially among glucose-6-phosphate dehydrogenase-deficient (G6PDd) people, without evidence demonstrating that it can be safely...

Trends in Early Initiation of Antiretroviral Therapy and Characteristics of Persons With HIV Initiating Therapy in San Francisco, 2007–2011

In 2010, the San Francisco Department of Public Health offered antiretroviral therapy (ART) to all its patients with human immunodeficiency virus (HIV) regardless of CD4 count. We assessed trends in time from diagnosis to ART initiation and factors associated with ART initiation among San Francisco residents living with HIV between 2007 and 2011. Time to ART initiation decreased...

Determinants of the creatinine clearance to glomerular filtration rate ratio in patients with chronic kidney disease: a cross-sectional study

Vittinghoff 4 Alan S Go 3 4 Chi-yuan Hsu 2 0 Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University , Taipei , Taiwan 1 Division of Nephrology, Department of

Theory-Informed Interventions to Improve the Quality of Tuberculosis Evaluation at Ugandan Health Centers: A Quasi-Experimental Study

Background Tuberculosis (TB) remains under-diagnosed in many countries, in part due to poor evaluation practices at health facilities. Theory-informed strategies are needed to improve implementation of TB evaluation guidelines. We aimed to evaluate the impact of performance feedback and same-day smear microscopy on the quality of TB evaluation at 6 health centers in rural Uganda...