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FTIR-ATR biosensor based on self-assembled phospholipids surface: Haemophilia factor VIII diagnosis

We report a new generic device suitable for the investigation of biological interactions by means of Fourier Transform Infrared (FTIR) spectroscopy. The research is focused on multi reflected evanescent optical radiation through a chemically modified surface of the attenuated total reflection (ATR) element (silicon or germanium). Using a wet chemistry approach, the original...

Correction: Discrimination of breast cancer from benign tumours using Raman spectroscopy

Goormaghtigh Khalid Al-Saad Mohamed H. Ali The following information is missing from the Funding section: This article was funded by the Qatar National Library. The funder had no role in study design, data

FTIR-ATR biosensor based on self-assembled phospholipids surface: Haemophilia factor VIII diagnosis

We report a new generic device suitable for the investigation of biological interactions by means of Fourier Transform Infrared (FTIR) spectroscopy. The research is focused on multi reflected evanescent optical radiation through a chemically modified surface of the attenuated total reflection (ATR) element (silicon or germanium). Using a wet chemistry approach, the original...

Monitoring of metabolism perturbation in prostate PC-3 cancer cells by sub-lethal concentrations of methotrexate

Interuniversity Attraction Poles (IAP) P6/19 (Bel gium) and the National Fund for Scientific Research (FRFC 2.4533.10 and 2.4588.06). Erik Goormaghtigh is Directors of Research with the ?National Fund for

Monitoring of metabolism perturbation in prostate PC-3 cancer cells by sub-lethal concentrations of methotrexate

Interuniversity Attraction Poles (IAP) P6/19 (Bel gium) and the National Fund for Scientific Research (FRFC 2.4533.10 and 2.4588.06). Erik Goormaghtigh is Directors of Research with the “National Fund for

ATR–FTIR, a new tool to analyze the oligomeric content of Aβ samples in the presence of apolipoprotein E isoforms

Alzheimer̕s disease (AD) is a neurodegenerative disorder caused by the aggregation of the amyloid-beta peptide (Aβ), leading to amyloid plaques deposition in the brain. Although Aβ aggregation pathway still remains unclear, recent studies point out the enhanced toxicity of oligomers compared to fibrils. The E4 isoform of apolipoprotein E (ApoE) is the major risk factor in AD as...

Data processing in FTIR imaging of cells: Towards protein secondary structure imaging

Bioinformatics, Universite? Libre de Bruxelles , Brussels , Belgium 1 Erik Goormaghtigh 2 for Structural Biology and Bioinformatics, Campus Plaine CP206/02, Universite? Libre de Bruxelles , Bld du Triomphe 2 ... Poles (IAP) P6/19 (Belgium) and the National Fund for Scientific Research (FRFC 2.4533.10 and 2.4588.06). Erik Goormaghtigh and Vincent Raussens are respectively Director of Research and Senior Research

Data processing in FTIR imaging of cells: Towards protein secondary structure imaging

Bioinformatics, Universite? Libre de Bruxelles , Brussels , Belgium 1 Erik Goormaghtigh 2 for Structural Biology and Bioinformatics, Campus Plaine CP206/02, Universite? Libre de Bruxelles , Bld du Triomphe 2 ... Poles (IAP) P6/19 (Belgium) and the National Fund for Scientific Research (FRFC 2.4533.10 and 2.4588.06). Erik Goormaghtigh and Vincent Raussens are respectively Director of Research and Senior Research

ATR–FTIR, a new tool to analyze the oligomeric content of Aβ samples in the presence of apolipoprotein E isoforms

Alzheimer̕s disease (AD) is a neurodegenerative disorder caused by the aggregation of the amyloid-beta peptide (Aβ), leading to amyloid plaques deposition in the brain. Although Aβ aggregation pathway still remains unclear, recent studies point out the enhanced toxicity of oligomers compared to fibrils. The E4 isoform of apolipoprotein E (ApoE) is the major risk factor in AD as...

Development of a quantitative and conformation-sensitive ATR-FTIR biosensor for Alzheimer's disease: The effect of deuteration on the detection of the Aβ peptide

Alzheimer's disease (AD) is the most common form of dementia worldwide and represents a growing socio-economical issue. To date, no reliable diagnosis can be obtained at an early-stage of the disease, though it is now recognized that the aggregation of the amyloid β (Aβ) peptide is responsible for the onset of the disease. Recent studies have shown that soluble amyloid oligomers...

Discrimination of breast cancer from benign tumours using Raman spectroscopy

, Rafif Al Saady, Erik Goormaghtigh, Khalid Al-Saad, Mohamed H. Ali. 12 / 13 1. Ferlay J. , Soerjomataram I. , Dikshit R. , Eser S. , Mathers C. , Rebelo M. , Parkin , et al. Cancer incidence and ... . Investigation: Aidan D. Meade. Project administration: Khalid Al-Saad. Resources: Fazle Rakib, Rafif Al-Saady. Software: Fazle Rakib. Supervision: Damien Traynor, Aidan D. Meade, Rafif Al-Saady, Erik

Data processing in FTIR imaging of cells: Towards protein secondary structure imaging

Bioinformatics, Universite? Libre de Bruxelles , Brussels , Belgium 1 Erik Goormaghtigh 2 for Structural Biology and Bioinformatics, Campus Plaine CP206/02, Universite? Libre de Bruxelles , Bld du Triomphe 2 ... Poles (IAP) P6/19 (Belgium) and the National Fund for Scientific Research (FRFC 2.4533.10 and 2.4588.06). Erik Goormaghtigh and Vincent Raussens are respectively Director of Research and Senior Research

A FTIR Imaging Characterization of Fibroblasts Stimulated by Various Breast Cancer Cell Lines

It is well known that the microenvironment plays a major role in breast cancer progression. Yet, the mechanism explaining the transition from normal fibroblasts to cancer-stimulated fibroblasts remains to be elucidated. Here we report a FTIR imaging study of the effects of three different breast cancer cell lines on normal fibroblasts in culture. Fibroblast activation process was...

Intraspecific variability of cadmium tolerance and accumulation, and cadmium-induced cell wall modifications in the metal hyperaccumulator Arabidopsis halleri

Certain molecular mechanisms of Cd tolerance and accumulation have been identified in the model species Arabidopsis halleri, while intraspecific variability of these traits and the mechanisms of shoot detoxification were little addressed. The Cd tolerance and accumulation of metallicolous and non-metallicolous A. halleri populations from different genetic units were tested in...

The N-terminal domain of the enzyme I is a monomeric well-folded protein with a low conformational stability and residual structure in the unfolded state

The bacterial phosphoenolpyruvate-dependent sugar phosphotransferase system is a multiprotein complex that phosphorylates and, concomitantly, transports carbohydrates across the membrane into the cell. The first protein of the cascade is a multidomain protein so-called enzyme I (EI). The N-terminal domain of EI from Streptomyces coelicolor, EINsc, responsible for the binding to...