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Search: authors:"Ernst Lengyel"

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Statin Therapy Is Associated with Improved Survival in Patients with Non-Serous-Papillary Epithelial Ovarian Cancer: A Retrospective Cohort Analysis

Aim To determine whether statin use is associated with improved epithelial ovarian cancer (OvCa) survival. Methods This is a single-institution retrospective cohort review of patients treated for OvCa between 1992 and 2013. Inclusion criteria were International Federation of Gynecology and Obstetrics (FIGO) stage I–IV OvCa. The primary exposures analyzed were hyperlipidemia and...

Rac1 and Rho contribute to the migratory and invasive phenotype associated with somatic E-cadherin mutation

Recent evidence suggests a close association between extracellular E-cadherin mutation in diffuse-type gastric carcinoma and the acquisition of a migratory phenotype of tumour cells. To characterize the cellular machinery that mediates the gain of motility of tumour cells with mutant E-cadherin, we turned to the small Rho GTPases Rac1 and Rho because they have been implicated in...

CD95 promotes tumour growth

Lengyel Marcus E. Peter p-JNK JNK p-Jun Jun CASP- IgGJo2IgG Jo2 - PH

Rac1b, a tumor associated, constitutively active Rac1 splice variant, promotes cellular transformation

A novel splice variant of Rac1, designated Rac1b, is expressed in human breast and colon carcinoma cells. Rac1b contains an additional 19 amino-acid insert immediately behind the switch II domain, a region important for Rac1 interaction with regulators and effectors. Recent studies showed that Rac1b exhibited the biochemical properties of a constitutively activated GTPase, yet it...

Role of β3-endonexin in the regulation of NF-κB-dependent expression of urokinase-type plasminogen activator receptor

translation start (Hapke et al., 2001a; Lengyel et al., 1996) was a kind gift from Ernst Lengyel (University of California, San Francisco). The NF-k B-mutated CAT-construct (uPAR-CAT mt-45) that has a