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Concurrent exercise improves insulin resistance and nonalcoholic fatty liver disease by upregulating PPAR-γ and genes involved in the beta-oxidation of fatty acids in ApoE-KO mice fed a high-fat diet

To emphasize the mechanism of concurrent exercise effect on lipid disorders in insulin resistance (IR) and nonalcoholic fatty liver disease (NAFLD). Twenty male ApoE knockout mice were randomly divided into two groups: HFD group (n = 10) fed a high fat diet, and HFDE group (n = 10) with high-fat diet intervention for 12 weeks and swimming exercise. Other ten healthy male C57BL/6...

Effects of an Outpatient Diabetes Self-Management Education on Patients with Type 2 Diabetes in China: A Randomized Controlled Trial

; Revised 7 December 2018; Accepted 26 December 2018; Published 17 January 2019 Academic Editor: Gianluca Iacobellis Copyright © 2019 Fan Zheng et al. This is an open access article distributed under the

Sequence statistics of tertiary structural motifs reflect protein stability

The Protein Data Bank (PDB) has been a key resource for learning general rules of sequence-structure relationships in proteins. Quantitative insights have been gained by defining geometric descriptors of structure (e.g., distances, dihedral angles, solvent exposure, etc.) and observing their distributions and sequence preferences. Here we argue that as the PDB continues to grow...

Shift current bulk photovoltaic effect in polar materials—hybrid and oxide perovskites and beyond

The bulk photovoltaic effect (BPVE) refers to the generation of a steady photocurrent and above-bandgap photovoltage in a single-phase homogeneous material lacking inversion symmetry. The mechanism of BPVE is decidedly different from the typical p–n junction-based photovoltaic mechanism in heterogeneous materials. Recently, there has been renewed interest in ferroelectric...

Substantial bulk photovoltaic effect enhancement via nanolayering

information AffiliationsThe Makineni Theoretical Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, USAFenggong Wang, Fan Zheng, Ilya Grinberg & Andrew M ... ScholarSearch for Steve M. Young in:Nature Research journals • PubMed • Google ScholarSearch for Fan Zheng in:Nature Research journals • PubMed • Google ScholarSearch for Ilya Grinberg in:Nature Research journals

Fission yeast mitochondria are distributed by dynamic microtubules in a motor-independent manner

Foundation of China (31271518). Author information AffiliationsDepartment of BiochemistryTianpeng Li, Fan Zheng & Chuanhai FuDepartment of Anatomy, The University of Hong Kong, Pokfulam, Hong Kong ... , ChinaMartin CheungHKU-Shenzhen Institute of Research and Innovation, The University of Hong Kong, Shenzhen, ChinaTianpeng Li, Fan Zheng & Chuanhai FuSchool of Life Sciences, Anhui Medical University, Hefei

Design of a polarization-insensitive superconducting nanowire single photon detector with high detection efficiency

Superconducting nanowire single photon detectors (SNSPDs) deliver superior performance over their competitors in the near-infrared regime. However, these detectors have an intrinsic polarization dependence on the incident wave because of their one-dimensional meander structure. In this paper, we propose an approach to eliminate the polarization sensitivity of SNSPDs by using near...

Dynamic Autophosphorylation of Mps1 Kinase Is Required for Faithful Mitotic Progression

The spindle assembly checkpoint (SAC) is a surveillance mechanism monitoring cell cycle progression, thus ensuring accurate chromosome segregation. The conserved mitotic kinase Mps1 is a key component of the SAC. The human Mps1 exhibits comprehensive phosphorylation during mitosis. However, the related biological relevance is largely unknown. Here, we demonstrate that 8...

Non-steroidal Anti-inflammatory Drug Use and the Risk of Gastric Cancer: A Systematic Review and Meta-analysis

Background: The relationship between the use of non-steroidal anti-inflammatory drugs (NSAIDs), including aspirin, and the risk of gastric cancer has not been well studied. We performed a systematic review and meta-analysis of published studies to evaluate the association between use of this class of drugs and the risk of gastric cancer. Methods: A fully recursive literature...