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The BET inhibitor I-BET762 inhibits pancreatic ductal adenocarcinoma cell proliferation and enhances the therapeutic effect of gemcitabine

As one of the most fatal malignancies, pancreatic ductal adenocarcinoma (PDAC) has significant resistance to the currently available treatment approaches. Gemcitabine, the standard chemotherapeutic agent for locally advanced and metastatic PDAC, has limited efficacy, which is attributed to innate/acquired resistance and the activation of prosurvival pathways. Here, we...

Highly Sensitive Plasmonic Detection of the Pancreatic Cancer Biomarker CA 19-9

Scholar Search for Long R. Jiao in:Nature Research journals • PubMed • Google Scholar Search for Fang Xie in:Nature Research journals • PubMed • Google Scholar Contributions Z.A.R.J. designed and ... idea and supervised the project. Competing Interests The authors declare that they have no competing interests. Corresponding author Correspondence to Fang Xie. Electronic supplementary material

Differential effects of reticulophagy and mitophagy on nonalcoholic fatty liver disease

Autophagy affects the pathological progression of non-alcoholic fatty liver disease (NAFLD); however, the precise role of autophagy in NAFLD remains unclear. In this study, we want to identify the role of autophagy including reticulophagy and mitophagy in NAFLD pathogenesis. When HepG2 cells were treated with 400 μM oleic acid (OA), increased reticulophagy was induced 8 h after...

Compatibility Study of Danggui Buxue Tang on Chemical Ingredients, Angiogenesis and Endothelial Function

Danggui Buxue Tang (DBT) is a classic Chinese herbal formula which consists of Astragali mongholici Radix and Angelica sinensis Radix (ASR). For chemical ingredients, HPLC were performed. Results showed compared with single herbs, DBT decoction could promote the dissolution of ingredients such as ferulic acid and calycosin. Furthermore, when ratio of AMR to ASR was 5 to 1...

Hydrogenations and electric field induced magnetic behaviors in armchair silicene nanoribbons

Using the first-principles calculations, we investigate the geometric, electronic and magnetic properties of armchair silicene nanoribbons with different edge hydrogenations. Our results show that the interesting magnetic behaviors such as the bipolar magnetic semiconductor can be found. Moreover, the addition of the transverse electric field can modulate the bipolar magnetic...

Significant Broadband Photocurrent Enhancement by Au-CZTS Core-Shell Nanostructured Photocathodes

Copper zinc tin sulfide (CZTS) is a promising material for harvesting solar energy due to its abundance and non-toxicity. However, its poor performance hinders their wide application. In this paper gold (Au) nanoparticles are successfully incorporated into CZTS to form Au@CZTS core-shell nanostructures. The photocathode of Au@CZTS nanostructures exhibits enhanced optical...

Salvianolic acid B ameliorates depressive-like behaviors in chronic mild stress-treated mice: involvement of the neuroinflammatory pathway

-fang XIE and Shuo YAN isolated natural product; Qiu-ying ZHAO conducted the data analysis; Jin-qiang ZHANG, Xiao-hui WU wrote the first-draft manuscript and Zi-li YOU revised the manuscript ... Research, Development and Utilization of Chinese Medicine Resources, College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, ChinaXiao-fang Xie & Cheng Peng AuthorsSearch for

Phenothiazine Derivative-Accelerated Microbial Extracellular Electron Transfer in Bioelectrochemical System

AffiliationsDepartment of Chemistry, University of Science & Technology of China, Hefei, 230026, ChinaXian-Wei Liu, Jie-Jie Chen, Yu-Xi Huang, Jia-Fang Xie, Wen-Wei Li, Guo-Ping Sheng, Yuan-Yuan Zhang, Rui Lu & Han-Qing ... • PubMed • Google ScholarSearch for Yu-Xi Huang in:Nature Research journals • PubMed • Google ScholarSearch for Jia-Fang Xie in:Nature Research journals • PubMed • Google ScholarSearch for Wen-Wei Li

Influence of fluvastatin on cardiac function and baroreflex sensitivity in diabetic rats

contribution Jing AI, Li-hua SUN, and Bao-feng YANG designed the research and supervised the project; Fang XIE and Chao SUN established the diabetic model; Jing-yuan LI and Guan-yi LU measured food and drink ... intake; Chao SUN, Xin CHEN, and Hui CHE performed the animal studies, including the biochemical indexes of blood and the recording of blood pressure, HR and BRS; Jing AI, Fang XIE, and Chao SUN analyzed