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A clinical evaluation committee assessment of recombinant human tissue factor pathway inhibitor (tifacogin) in patients with severe community-acquired pneumonia

Introduction The purpose of this analysis was to determine the potential efficacy of recombinant human tissue factor pathway inhibitor (tifacogin) in a subpopulation of patients with community-acquired pneumonia (CAP) from a phase III study of severe sepsis. Methods A retrospective review of patients with suspected pneumonia was conducted by an independent clinical evaluation...

ASPP2 Inhibits the Profibrotic Effects of Transforming Growth Factor-β1 in Hepatic Stellate Cells by Reducing Autophagy

BackgroundApoptosis-stimulating protein of p53-2 (ASPP2) is a damage-inducible P53-binding protein that enhances damage-induced apoptosis. Fibrosis is a wound-healing response, and hepatic stellate cells (HSCs) are key players in liver fibrogenesis. However, little is known about the relationship between ASPP2 and hepatic fibrosis.AimsWe investigated the effects of ASPP2...

Activated Effects of Parathyroid Hormone-Related Protein on Human Hepatic Stellate Cells

Background & Aims After years of experiments and clinical studies, parathyroid hormone-related protein(PTHrP) has been shown to be a bone formation promoter that elicits rapid effects with limited adverse reaction. Recently, PTHrP was reported to promote fibrosis in rat kidney in conjunction with transforming growth factor-beta1 (TGF-β1), which is also a fibrosis promoter in...

Attenuated Actinobacillus pleuropneumoniae double-deletion mutant S-8∆clpP/apxIIC confers protection against homologous or heterologous strain challenge

Background Actinobacillus pleuropneumoniae is the etiological agent of porcine pleuropneumonia, which leads to large economic losses to the swine industry worldwide. In this study, S-8△clpP△apxIIC, a double-deletion mutant of A. pleuropneumoniae was constructed, and its safety and protective efficacy were evaluated in pigs. Results The S-8△clpP△apxIIC mutant exhibited attenuated...

Autocrine parathyroid hormone-like hormone promotes intrahepatic cholangiocarcinoma cell proliferation via increased ERK/JNK-ATF2-cyclinD1 signaling

Intrahepatic cholangiocarcinoma (ICC) is an aggressive tumor with a high fatality rate. It was recently found that parathyroid hormone-like hormone (PTHLH) was frequently overexpressed in ICC compared with non-tumor tissue. This study aimed to elucidate the underlying mechanisms of PTHLH in ICC development. The CCK-8 assay, colony formation assays, flow cytometry and a xenograft...

Chromosomal Rearrangement Features of Yersinia pestis Strains from Natural Plague Foci in China

for Health Sector, People’s Republic of China, and grant (2012ZX10004215) from the National Key Programs for Infectious Diseases of China. Authors’ addresses: Ying Liang, Fang Xie, Enmin Zhang, Zhikai

Collagen scaffolds modified with collagen-binding bFGF promotes the neural regeneration in a rat hemisected spinal cord injury model

Nerve conduit is one of strategies for spine cord injury (SCI) treatment. Recently, studies showed that biomaterials could guide the neurite growth and promote axon regeneration at the injury site. However, the scaffold by itself was difficult to meet the need of SCI functional recovery. The basic fibroblast growth factor (bFGF) administration significantly promotes functional...

Compatibility Study of Danggui Buxue Tang on Chemical Ingredients, Angiogenesis and Endothelial Function

Danggui Buxue Tang (DBT) is a classic Chinese herbal formula which consists of Astragali mongholici Radix and Angelica sinensis Radix (ASR). For chemical ingredients, HPLC were performed. Results showed compared with single herbs, DBT decoction could promote the dissolution of ingredients such as ferulic acid and calycosin. Furthermore, when ratio of AMR to ASR was 5 to 1...

Differential effects of reticulophagy and mitophagy on nonalcoholic fatty liver disease

Autophagy affects the pathological progression of non-alcoholic fatty liver disease (NAFLD); however, the precise role of autophagy in NAFLD remains unclear. In this study, we want to identify the role of autophagy including reticulophagy and mitophagy in NAFLD pathogenesis. When HepG2 cells were treated with 400 μM oleic acid (OA), increased reticulophagy was induced 8 h after...

Downregulation of miR-132 by promoter methylation contributes to pancreatic cancer development

MicroRNAs (miRNAs), which regulate gene expression by partial complementarity to the 3′ untranslated region of their target genes, have been implicated in cancer initiation and progression. However, the molecular mechanism underlying the regulation of miRNA expression during pancreatic tumorigenesis has not been extensively reported. In this study, we first compared the miRNA...

Evaluation of Liver Ischemia-Reperfusion Injury in Rabbits Using a Nanoscale Ultrasound Contrast Agent Targeting ICAM-1

Objective To assess the feasibility of ultrasound molecular imaging in the early diagnosis of liver ischemia-reperfusion injury (IRI) using a nanoscale contrast agent targeting anti-intracellular adhesion molecule-1 (anti-ICAM-1). Methods The targeted nanobubbles containing anti-ICAM-1 antibody were prepared using the avidin-biotin binding method. Human hepatic sinusoidal...

Evolutionary Position and Leaf Toughness Control Chemical Transformation of Litter, and Drought Reinforces This Control: Evidence from a Common Garden Experiment across 48 Species

Plant leaf litter is an important source of soil chemicals that are essential for the ecosystem and changes in leaf litter chemical traits during decomposition will determine the availability of multiple chemical elements recycling in the ecosystem. However, it is unclear whether the changes in litter chemical traits during decomposition and their similarities across species can...

Fragile Histidine Triad (FHIT) Suppresses Proliferation and Promotes Apoptosis in Cholangiocarcinoma Cells by Blocking PI3K-Akt Pathway

Hu, Qiang Huang, Zhen Liu, and Fang Xie designed the study and wrote the paper. Qiang Huang, Zhen Liu, and Fang Xie performed all experimental procedures. Sanyuan Hu, Qiang Huang, Fang Xie, and Chenhai

Frequency Dependent Spencer Modeling of Magnetorheological Damper Using Hybrid Optimization Approach

Magnetorheological dampers have been widely used in civil and automotive industries. The nonlinear behavior of MR fluid makes MR damper modeling a challenging problem. In this paper, a frequency dependent MR damper model is proposed based on Spencer MR damper model. The parameters of the model are identified using an experimental data based hybrid optimization approach which is a...

Gadd45α: A Novel Diabetes-Associated Gene Potentially Linking Diabetic Cardiomyopathy and Baroreflex Dysfunction

Both diabetic cardiomyopathy (DCM) and baroreflex dysfunction independently contribute to sudden cardiac death (SCD), however the inherent connections between them under diabetic state remains unclear. As microRNAs (miRNAs) have been reported to participate in various physiological and pathological processes, we presume they may also be involved in DCM and DM-induced impairment...

Gray Matter Is Targeted in First-Attack Multiple Sclerosis

Xie Jonas Bergquist La szlo Ve csei Denes Zadori David G. Camp II Bart K. Holland Richard D. Smith Patricia K. Coyle Robert Shin Fujinami, University of Utah School of Medicine, United States of America

Haemophilus parasuis cytolethal distending toxin induces cell cycle arrest and p53-dependent apoptosis

Haemophilus parasuis is the causative agent of Glasser’s disease in pigs. Cytolethal distending toxin (CDT) is an important virulence factor of H. parasuis. It is composed of three subunits: CdtA, CdtB and CdtC and all were successfully expressed in soluble form in Escherichia coli when the signal peptides were removed. Purified CdtB had DNase activity, i.e. caused DNA double...

He's Max-Min Approach to a Nonlinear Oscillator with Discontinuous Terms

Received 25 December 2012; Accepted 29 December 2012 Copyright © 2013 Hui-Li Zhang and Fang Xie. This is an open access article distributed under the Creative Commons Attribution License, which permits

He's Max-Min Approach to a Nonlinear Oscillator with Discontinuous Terms

Received 25 December 2012; Accepted 29 December 2012 Copyright © 2013 Hui-Li Zhang and Fang Xie. This is an open access article distributed under the Creative Commons Attribution License, which permits

He's Max-Min Approach to a Nonlinear Oscillator with Discontinuous Terms

Received 25 December 2012; Accepted 29 December 2012 Copyright © 2013 Hui-Li Zhang and Fang Xie. This is an open access article distributed under the Creative Commons Attribution License, which permits